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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Revenue:        
Product sales, net $ 28,823 $ 13,530 $ 49,885 $ 37,067
Costs and expenses:        
Cost of product sales 342 147 606 414
Research and development 30,937 24,132 64,309 53,043
Selling, general and administrative 21,560 16,931 39,598 34,967
Total costs and expenses 52,839 41,210 104,513 88,424
Loss from operations (24,016) (27,680) (54,628) (51,357)
Interest expense (4,910) (5,978) (9,808) (11,880)
Other income 333 364 753 912
Net loss (28,593) (33,294) (63,683) (62,325)
Comprehensive loss $ (28,593) $ (33,294) $ (63,683) $ (62,325)
Basic net loss per share $ (0.46) $ (0.61) $ (1.02) $ (1.14)
Diluted net loss per share $ (0.46) $ (0.61) $ (1.02) $ (1.14)
Weighted-average shares used to compute basic net loss per share 62,373,521 54,513,337 62,154,714 54,406,575
Weighted-average shares used to compute diluted net loss per share 62,373,521 54,513,337 62,166,295 54,406,575