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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2022 | Jun. 30, 2021
Operating activities: |  |
Net loss | $ (63,860) | $ (63,683)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Early termination of operating lease | (454) |
Stock-based compensation expense | 6,964 | 6,388
Non-cash interest expense | 900 | 822
Depreciation and amortization | 469 | 745
Changes in operating assets and liabilities: |  |
Receivables | 23,676 | (27,997)
Prepaid expenses and other assets | (3,668) | 6,010
OMIDRIA contract royalty asset | 13,964 |
Accounts payable and accrued expense | (12,653) | 9,869
Net cash used in operating activities | (34,662) | (67,846)
Investing activities: |  |
Purchases of investments | (103,169) | (4)
Proceeds from the sale and maturities of investments | 51,200 | 63,500
Purchases of property and equipment | (103) | (100)
Net cash provided by (used in) investing activities | (52,072) | 63,396
Financing activities: |  |
Proceeds upon exercise of stock options and warrants | 414 | 7,468
Payments on finance lease obligations | (352) | (576)
At the market offering costs |  | (241)
Net cash provided by financing activities | 62 | 6,651
Net decrease in cash and cash equivalents | (86,672) | 2,201
Cash and cash equivalents at beginning of period | 100,808 | 10,501
Cash and cash equivalents at end of period | 14,136 | 12,702
Supplemental cash flow information |  |
Cash paid for interest | 8,998 | 9,012
Property acquired under finance lease | $ 557 | $ 39

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