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Income Taxes - Significant Components of Deferred Tax Assets (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 85,887 | $ 143,657
Research and development tax credits | 78,992 | 66,612
OMIDRIA royalty obligation | 28,938 |
Capitalized research and development | 21,864 |
Stock-based compensation | 12,517 | 11,327
Lease liability | 5,926 | 9,995
Other | 9,234 | 17,862
Total deferred tax assets | 243,358 | 249,453
Deferred tax liabilities: |  |
Gain on discontinued operations | (34,883) | (42,212)
Right of use assets | (4,987) | (6,467)
Property and equipment | (288) | (102)
Total deferred tax liabilities | (40,158) | (48,781)
Net deferred tax assets before valuation allowance | 203,200 | 200,672
Less valuation allowance | (203,200) | (201,340)
Net deferred tax liabilities | $ 0 | $ (668)

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