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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2022
Stock-Based Compensation. |
Schedule of equity plan | Vesting schedules for our equity plans generally are as follows:
​ | ​ | ​
Grant Type |  | Vesting Schedule
Employee initial options grants |  | 25% at one-year anniversary, 1/48 monthly thereafter
Employee recurring options grants |  | 1/48 monthly
Non-employee consultant options grants |  | 1/12 or 1/48 monthly
Employee RSUs | ​ | 50% after one year, 50% after two years
​
Stock-Based Compensation Expense | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended December 31,
​ |  | 2022 |  | 2021 |  | 2020
​ | ​ | (In thousands)
Continuing operations: | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Research and development | ​ | $ | 6,123 | ​ | $ | 6,791 | ​ | $ | 6,163
Selling, general and administrative | ​ |  | 8,042 | ​ |  | 8,154 | ​ |  | 7,614
Total stock-based compensation in continuing operations | ​ | ​ | 14,165 | ​ | ​ | 14,945 | ​ | ​ | 13,777
Discontinued operations | ​ | ​ | (93) | ​ | ​ | 2,685 | ​ | ​ | 1,148
Total stock-based compensation | ​ | $ | 14,072 | ​ | $ | 17,630 | ​ | $ | 14,925
​
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | Year Ended December 31, |
​ | ​ | 2022 | ​ | ​ | 2021 | ​ | ​ | 2020 | ​
Estimated weighted-average fair value | ​ | $ | 2.94 | ​ | ​ | $ | 10.54 | ​ | ​ | $ | 8.19 | ​
Weighted-average assumptions: | ​ |  | ​ | ​ | ​ |  |  | ​ | ​ |  |  | ​
Expected volatility | ​ |  | 90 | % | ​ |  | 81 | % | ​ |  | 77 | %
Expected life, in years | ​ |  | 6.0 | ​ | ​ |  | 6.0 | ​ | ​ |  | 6.0 | ​
Risk-free interest rate | ​ |  | 2.83 | % | ​ |  | 1.06 | % | ​ |  | 1.06 | %
Expected dividend yield | ​ |  | — | % | ​ |  | — | % | ​ |  | — | %
​
Schedule of Stock Option Activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | Weighted- |  | ​ |  | ​ | ​
​ | ​ | ​ | ​ | Average | ​ | ​ | ​ | Aggregate
​ | ​ | ​ | ​ | Exercise | ​ | Remaining | ​ | Intrinsic
​ | ​ | Options | ​ | Price per | ​ | Contractual Life | ​ | Value
​ | ​ | Outstanding | ​ | Share | ​ | (In years) | ​ | (In thousands)
Balance at December 31, 2021 |  | 12,709,887 | ​ | $ | 12.61 |  |  |  | ​ |
Granted |  | 2,742,834 | ​ |  | 3.81 |  |  |  | ​ |
Exercised |  | (101,160) | ​ |  | 4.10 |  |  |  | ​ |
Forfeited |  | (1,478,588) | ​ |  | 12.05 |  |  |  | ​ |
Balance at December 31, 2022 |  | 13,872,973 | ​ | $ | 11.02 |  | 5.8 | ​ | $ | 21
Vested and expected to vest at December 31, 2022 |  | 13,454,543 | ​ | $ | 11.10 |  | 5.7 | ​ | $ | 19
Exercisable at December 31, 2022 |  | 9,859,720 | ​ | $ | 12.12 |  | 4.6 | ​ | $ | —
​
Schedule of RSU activity | ​
​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | Weighted- Average
​ | ​ | ​ | ​ | Grant Date
​ | ​ | RSUs | ​ | Fair Value
​ | ​ | Outstanding | ​ | Per Share
Balance at December 31, 2021 |  | 222,000 | ​ | $ | 7.53
Vested and released |  | (98,750) | ​ |  | 7.53
Forfeited |  | (24,500) | ​ |  | 7.53
Balance at December 31, 2022 |  | 98,750 | ​ | $ | 7.53

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