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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Operating activities: |  |  |
Net income (loss) | $ 47,417 | $ 194,235 | $ (138,061)
Adjustments to reconcile net income (loss) to net cash used in operating activities: |  |  |
Stock-based compensation expense | 14,072 | 17,630 | 14,925
Gain on sale of OMIDRIA, gross |  | (310,563) |
Non-cash interest expense on unsecured convertible debt | 1,830 | 1,696 | 11,649
Non-cash interest expense on future royalty obligation | 1,695 |  |
Depreciation and amortization | 952 | 1,386 | 1,616
Noncash adjustments on buyout of equipment finance leases | 64 |  |
Remeasurement on OMIDRIA contract royalty asset | (18,634) |  |
Interest on OMIDRIA contract royalty asset | (14,457) |  |
Early termination of operating lease | (454) |  |
Loss on early extinguishment of debt |  |  | 13,374
Deferred income tax |  |  | (12,011)
Fair value settlement upon termination of cap call contract |  |  | 838
Changes in operating assets and liabilities: |  |  |
Receivables | (175,066) | (34,314) | 31,344
Prepaid expenses and other | 1,324 | 5,568 | (4,024)
OMIDRIA contract royalty asset | 65,439 |  |
Accounts payable and accrued expense | (10,665) | 14,640 | (19,736)
Net cash used in operating activities | (86,483) | (109,722) | (100,086)
Investing activities: |  |  |
Cash proceeds on sale of OMIDRIA |  | 125,993 |
Purchases of investments | (429,045) | (32,006) | (133,194)
Proceeds from the sale and maturities of investments | 301,594 | 100,000 | 66,446
Purchases of property and equipment | (113) | (277) | (283)
Net cash provided by (used in) investing activities | (127,564) | 193,710 | (67,031)
Financing activities: |  |  |
Proceeds upon entering into OMIDRIA royalty obligation | 125,000 |  |
Principal payments on OMIDRIA royalty obligations | (417) |  |
Proceeds from issuance of convertible debt |  |  | 225,030
Payments for debt issuance costs |  |  | (6,785)
Purchases of capped calls related to convertible senior notes |  |  | (23,223)
Payments for repurchases of convertible senior notes |  |  | (125,638)
Proceeds from termination of capped call contracts |  |  | 7,549
Proceeds from issuance of common stock, net |  |  | 93,675
Release in restricted investments |  |  | 99
Proceeds upon exercise of stock options and warrants | 415 | 8,383 | 5,022
Payments on finance lease obligations | (750) | (1,823) | (1,195)
At the market offering costs |  | (241) |
Net cash provided by financing activities | 124,248 | 6,319 | 174,534
Net increase (decrease) in cash and cash equivalents | (89,799) | 90,307 | 7,417
Cash and cash equivalents at beginning of period | 100,808 | 10,501 | 3,084
Cash and cash equivalents at end of period | 11,009 | 100,808 | 10,501
Supplemental cash flow information |  |  |
Cash paid for interest | 19,178 | 17,876 | 11,603
Equipment acquired under finance lease | $ 40 | $ 289 | $ 216

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