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Income Taxes - Narrative (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Income Taxes |  |  |
Income tax benefit | $ 0 | $ 0 | $ 23,256
Income tax expense | 3,952 | 1,006 | 11,245
Income tax payable | 4,871 | 338 |
Capitalized research and development | $ 21,864 |  |
Deferred tax assets, percentage of valuation allowance | 100.00% |  |
Decrease in deferred tax valuation allowance | $ 1,900 | 19,300 |
Research Tax Credit Carryforward |  |  |
Income Taxes |  |  |
Tax credit carryforward | 79,200 |  |
Discontinued Operation | Omidria Assets Disposal |  |  |
Income Taxes |  |  |
Income tax expense | 3,952 | 1,006 | $ 11,245
Federal |  |  |
Income Taxes |  |  |
NOLs utilized during the year | 269,800 | 245,100 |
Net operating loss carryforwards | 361,000 |  |
Net operating loss carryforwards with expiration | 109,400 |  |
Net operating loss carryforwards with no expiration | 251,600 |  |
State |  |  |
Income Taxes |  |  |
Net operating loss carryforwards | 220,000 |  |
State | Discontinued Operation | Omidria Assets Disposal |  |  |
Income Taxes |  |  |
Income tax expense | $ 4,000 | $ 1,000 |

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