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Organization and Basis of Presentation (Details)
$ in Thousands
 12 Months Ended
Dec. 29, 2022
USD ($)
Dec. 23, 2021
USD ($)
Dec. 31, 2022
USD ($)
segment
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Aug. 14, 2020
USD ($)
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]            
Cash proceeds on sale of OMIDRIA       $ 125,993    
Cash, cash equivalents and short-term investments     $ 194,900      
Receivables, net     213,221 38,155    
Net cash used in operating activities     86,483 109,722 $ 100,086  
Long-term Debt, Gross     320,030 320,030    
Income     $ 47,417 194,235 $ (138,061)  
Number of Operating Segments | segment     1      
2023 Unsecured Convertible Senior Notes            
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]            
Long-term Debt, Gross     $ 95,000 95,000   $ 95,000
Discontinued Operation | Omidria Assets Disposal            
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]            
Cash proceeds on sale of OMIDRIA   $ 126,000   $ 125,993    
Milestone payment receivable $ 200,000   200,000      
Period payment is due after milestone period achieved 30 days          
Milestone period 4 years          
Market Offerings            
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]            
Maximum aggregate offering price     $ 150,000