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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Operating activities:      
Net income (loss) $ 47,417 $ 194,235 $ (138,061)
Adjustments to reconcile net income (loss) to net cash used in operating activities:      
Stock-based compensation expense 14,072 17,630 14,925
Gain on sale of OMIDRIA, gross   (310,563)  
Non-cash interest expense on unsecured convertible debt 1,830 1,696 11,649
Non-cash interest expense on future royalty obligation 1,695    
Depreciation and amortization 952 1,386 1,616
Noncash adjustments on buyout of equipment finance leases 64    
Remeasurement on OMIDRIA contract royalty asset (18,634)    
Interest on OMIDRIA contract royalty asset (14,457)    
Early termination of operating lease (454)    
Loss on early extinguishment of debt     13,374
Deferred income tax     (12,011)
Fair value settlement upon termination of cap call contract     838
Changes in operating assets and liabilities:      
Receivables (175,066) (34,314) 31,344
Prepaid expenses and other 1,324 5,568 (4,024)
OMIDRIA contract royalty asset 65,439    
Accounts payable and accrued expense (10,665) 14,640 (19,736)
Net cash used in operating activities (86,483) (109,722) (100,086)
Investing activities:      
Cash proceeds on sale of OMIDRIA   125,993  
Purchases of investments (429,045) (32,006) (133,194)
Proceeds from the sale and maturities of investments 301,594 100,000 66,446
Purchases of property and equipment (113) (277) (283)
Net cash provided by (used in) investing activities (127,564) 193,710 (67,031)
Financing activities:      
Proceeds upon entering into OMIDRIA royalty obligation 125,000    
Principal payments on OMIDRIA royalty obligations (417)    
Proceeds from issuance of convertible debt     225,030
Payments for debt issuance costs     (6,785)
Purchases of capped calls related to convertible senior notes     (23,223)
Payments for repurchases of convertible senior notes     (125,638)
Proceeds from termination of capped call contracts     7,549
Proceeds from issuance of common stock, net     93,675
Release in restricted investments     99
Proceeds upon exercise of stock options and warrants 415 8,383 5,022
Payments on finance lease obligations (750) (1,823) (1,195)
At the market offering costs   (241)  
Net cash provided by financing activities 124,248 6,319 174,534
Net increase (decrease) in cash and cash equivalents (89,799) 90,307 7,417
Cash and cash equivalents at beginning of period 100,808 10,501 3,084
Cash and cash equivalents at end of period 11,009 100,808 10,501
Supplemental cash flow information      
Cash paid for interest 19,178 17,876 11,603
Equipment acquired under finance lease $ 40 $ 289 $ 216