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Income Taxes - Significant Components of Deferred Tax Assets (Details) - USD ($)
$ in Thousands
Dec. 31, 2022
Dec. 31, 2021
Deferred tax assets:    
Net operating loss carryforwards $ 85,887 $ 143,657
Research and development tax credits 78,992 66,612
OMIDRIA royalty obligation 28,938  
Capitalized research and development 21,864  
Stock-based compensation 12,517 11,327
Lease liability 5,926 9,995
Other 9,234 17,862
Total deferred tax assets 243,358 249,453
Deferred tax liabilities:    
Gain on discontinued operations (34,883) (42,212)
Right of use assets (4,987) (6,467)
Property and equipment (288) (102)
Total deferred tax liabilities (40,158) (48,781)
Net deferred tax assets before valuation allowance 203,200 200,672
Less valuation allowance (203,200) (201,340)
Net deferred tax liabilities $ 0 $ (668)