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Income Taxes - Narrative (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Income Taxes      
Income tax benefit $ 0 $ 0 $ 23,256
Income tax expense 3,952 1,006 11,245
Income tax payable 4,871 338  
Capitalized research and development $ 21,864    
Deferred tax assets, percentage of valuation allowance 100.00%    
Decrease in deferred tax valuation allowance $ 1,900 19,300  
Research Tax Credit Carryforward      
Income Taxes      
Tax credit carryforward 79,200    
Discontinued Operation | Omidria Assets Disposal      
Income Taxes      
Income tax expense 3,952 1,006 $ 11,245
Federal      
Income Taxes      
NOLs utilized during the year 269,800 245,100  
Net operating loss carryforwards 361,000    
Net operating loss carryforwards with expiration 109,400    
Net operating loss carryforwards with no expiration 251,600    
State      
Income Taxes      
Net operating loss carryforwards 220,000    
State | Discontinued Operation | Omidria Assets Disposal      
Income Taxes      
Income tax expense $ 4,000 $ 1,000