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Note 13 - Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2023
Notes Tables |
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] |
|  | December 31, |
|  | 2023 |  |  | 2022 |  |  | 2021 |
|  | (In thousands) |
Continuing operations: |  |  |  |  |  |  |  |  |  |  |  |
Current income tax expense: |  |  |  |  |  |  |  |  |  |  |  |
Federal |  | $ | — |  |  | $ | — |  |  | $ | — |
State |  |  | — |  |  |  | — |  |  |  | — |
Total current income tax expense |  |  | — |  |  |  | — |  |  |  | — |
Deferred income tax benefit: |  |  |  |  |  |  |  |  |  |  |  |
Federal |  |  | — |  |  |  | — |  |  |  | — |
State |  |  | — |  |  |  | — |  |  |  | — |
Total deferred income tax benefit |  |  | — |  |  |  | — |  |  |  | — |
Income tax benefit in continuing operations |  | $ | — |  |  | $ | — |  |  | $ | — |
Income tax expense as a component of discontinued operations |  | $ | 462 |  |  | $ | 3,952 |  |  | $ | 1,006 |
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
|  | December 31, |
|  | 2023 |  |  | 2022 |
|  | (In thousands) |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 95,183 |  |  | $ | 85,887 |
Research and development tax credits |  |  | 92,837 |  |  |  | 78,992 |
Capitalized research and development |  |  | 39,318 |  |  |  | 21,864 |
OMIDRIA royalty obligation |  |  | 28,903 |  |  |  | 28,938 |
Stock-based compensation |  |  | 10,132 |  |  |  | 12,517 |
Lease liability |  |  | 5,085 |  |  |  | 5,926 |
Other |  |  | 10,283 |  |  |  | 9,234 |
Total deferred tax assets |  |  | 281,741 |  |  |  | 243,358 |
Deferred tax liabilities: |  |  |  |  |  |  |  |
OMIDRIA contract royalty asset |  |  | (38,832 | ) |  |  | (34,883 | )
Right of use assets |  |  | (4,304 | ) |  |  | (4,987 | )
Property and equipment |  |  | (122 | ) |  |  | (288 | )
Total deferred tax liabilities |  |  | (43,258 | ) |  |  | (40,158 | )
Net deferred tax assets before valuation allowance |  |  | 238,483 |  |  |  | 203,200 |
Less valuation allowance |  |  | (238,483 | ) |  |  | (203,200 | )
Net deferred tax liabilities |  | $ | — |  |  | $ | — |
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] |
|  | Year ended December 31, |
|  | 2023 |  |  | 2022 |  |  | 2021 |
U.S. Federal statutory rate on net loss |  |  | (21.0 | )% |  |  | (21.0 | )% |  |  | (21.0 | )%
State tax, net of federal tax benefit |  |  | (2.1 | )% |  |  | (1.7 | )% |  |  | (0.6 | )%
Change in valuation allowance |  |  | 27.7 | % |  |  | 28.3 | % |  |  | 26.9 | %
Tax credits |  |  | (8.0 | )% |  |  | (6.8 | )% |  |  | (5.5 | )%
Stock compensation |  |  | 1.5 | % |  |  | 1.4 | % |  |  | 0.3 | %
Other |  |  | 1.9 | % |  |  | (0.2 | )% |  |  | (0.1 | )%
Effective tax rate |  |  | 0.0 | % |  |  | 0.0 | % |  |  | 0.0 | %
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] |
Balance at December 31, 2022 |  | $ | 212 |
Increase in balance related to tax positions taken during prior years |  |  | 1,796 |
Decrease in balance related to tax positions during prior years |  |  | (30 | )
Decrease in balance as a result of a lapse of the applicable statute of limitations |  |  | (12 | )
Balance at December 31, 2023 |  | $ | 1,966 |

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