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Note 13 - Income Taxes (Details Textual) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Discontinued Operation, Tax Effect of Discontinued Operation | $ 462 | $ 3,952 | $ 1,006
Unrecognized Tax Benefits | 1,966 | 212 |
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued | 300 |  |
Unrecognized Tax Benefits that Would Impact Effective Tax Rate | 1,800 |  |
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense |  | 0 |
Research Tax Credit Carryforward [Member] |  |  |
Tax Credit Carryforward, Amount | 93,000 |  |
Omidria Assets Disposal [Member] | Discontinued Operations, Disposed of by Sale [Member] |  |  |
Discontinued Operation, Tax Effect of Discontinued Operation | (462) | (3,952) | (1,006)
Domestic Tax Authority [Member] |  |  |
Operating Loss Carryforwards | 398,600 | 361,400 | 630,600
Operating Loss Carryforwards Utilized | 268,600 | 245,100 |
Operating Loss Carryforwards Subject to Expiration | 109,800 |  |
Operating Loss Carryforwards Not Subject to Expiration | 288,800 |  |
State and Local Jurisdiction [Member] |  |  |
Operating Loss Carryforwards | $ 245,800 | 226,300 | 245,100
State and Local Jurisdiction [Member] | Omidria Assets Disposal [Member] | Discontinued Operations, Disposed of by Sale [Member] |  |  |
Discontinued Operation, Tax Effect of Discontinued Operation |  | $ 4,000 | $ 1,000

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- Definition Amount of tax expense (benefit) related to a discontinued operation. Includes, but is not limited to, tax expense (benefit) related to income (loss) from operations during the phase-out period, tax expense (benefit) related to gain (loss) on disposal, tax expense (benefit) related to gain (loss) for reversal of write-down (write-down) to fair value, less cost to sell, and tax expense (benefit) related to adjustments of a prior period gain (loss) on disposal. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 10 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482685/740-10-50-10 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 6.I.7) -Publisher FASB -URI https://asc.fasb.org//1943274/2147479360/740-10-S99-1 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 20 -Name Accounting Standards Codification -Section 45 -Paragraph 2 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482659/740-20-45-2 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 205 -SubTopic 20 -Name Accounting Standards Codification -Section 45 -Paragraph 3A -Publisher FASB -URI https://asc.fasb.org//1943274/2147483475/205-20-45-3A Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 205 -SubTopic 20 -Name Accounting Standards Codification -Section 50 -Paragraph 5B -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org//1943274/2147483499/205-20-50-5B Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 205 -SubTopic 20 -Name Accounting Standards Codification -Section 50 -Paragraph 5C -Subparagraph (b)(2) -Publisher FASB -URI https://asc.fasb.org//1943274/2147483499/205-20-50-5C Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 205 -SubTopic 20 -Name Accounting Standards Codification -Section 45 -Paragraph 3B -Publisher FASB -URI https://asc.fasb.org//1943274/2147483475/205-20-45-3B Reference 8: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 205 -SubTopic 20 -Name Accounting Standards Codification -Section 45 -Paragraph 4 -Publisher FASB -URI https://asc.fasb.org//1943274/2147483475/205-20-45-4 Reference 9: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 205 -SubTopic 20 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org//1943274/2147483499/205-20-50-1 + Details
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