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Note 12 - Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2023
Notes Tables |
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Schedule [Table Text Block] |
Grant Type | Vesting Schedule
Employee initial options grants | 25% at one-year anniversary, 1/48 monthly thereafter
Employee recurring options grants | 1/48 monthly
Non-employee consultant options grants | 1/12 or 1/48 monthly
Employee RSUs | 50% after one year, 50% after two years
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Year Ended December 31, |
|  | 2023 |  |  | 2022 |  |  | 2021 |
|  | (In thousands) |
Continuing operations: |  |  |  |  |  |  |  |  |  |  |  |
Research and development |  | $ | 4,754 |  |  | $ | 6,123 |  |  | $ | 6,791 |
Selling, general and administrative |  |  | 7,140 |  |  |  | 8,042 |  |  |  | 8,154 |
Total stock-based compensation in continuing operations |  |  | 11,894 |  |  |  | 14,165 |  |  |  | 14,945 |
Discontinued operations |  |  | (244 | ) |  |  | (93 | ) |  |  | 2,685 |
Total stock-based compensation |  | $ | 11,650 |  |  | $ | 14,072 |  |  | $ | 17,630 |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Year Ended December 31, |
|  | 2023 |  |  | 2022 |  |  | 2021 |
Estimated weighted-average fair value |  | $ | 2.44 |  |  | $ | 2.94 |  |  | $ | 10.54 |
Weighted-average assumptions: |  |  |  |  |  |  |  |  |  |  |  |
Expected volatility |  |  | 93 | % |  |  | 90 | % |  |  | 81 | %
Expected life, in years |  |  | 7.2 |  |  |  | 6.0 |  |  |  | 6.0 |
Risk-free interest rate |  |  | 3.97 | % |  |  | 2.83 | % |  |  | 1.06 | %
Expected dividend yield |  |  | — | % |  |  | — | % |  |  | — | %
Share-Based Payment Arrangement, Activity [Table Text Block] |
|  | Options Outstanding |  | Weighted- Average Exercise Price per Share |  | Remaining Contractual Life (In years) |  | Aggregate Intrinsic Value (In thousands) |
Balance at December 31, 2022 |  |  | 13,872,973 |  | $ | 11.02 |  |  |  |  |  |  |
Granted |  |  | 3,153,200 |  |  | 3.01 |  |  |  |  |  |  |
Exercised |  |  | (36,726 | ) |  | 4.10 |  |  |  |  |  |  |
Forfeited |  |  | (1,734,293 | ) |  | 9.96 |  |  |  |  |  |  |
Balance at December 31, 2023 |  |  | 15,255,154 |  | $ | 9.50 |  |  | 6.2 |  | $ | 1,388 |
Vested and expected to vest at December 31, 2023 |  |  | 14,762,090 |  | $ | 9.65 |  |  | 6.0 |  | $ | 1,272 |
Exercisable at December 31, 2023 |  |  | 10,554,140 |  | $ | 11.50 |  |  | 4.7 |  | $ | 217 |
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block] |
|  | RSUs Outstanding |  | Weighted- Average Grant Date Fair Value Per Share |
Balance at December 31, 2022 |  |  | 98,750 |  | $ | 7.53 |
Vested and released |  |  | (67,250 | ) |  | 7.53 |
Forfeited |  |  | (31,500 | ) |  | 7.53 |
Balance at December 31, 2023 |  |  | — |  | $ | — |

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