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Note 12 - Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2023

Notes Tables

Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Schedule [Table Text Block]

Grant Type	Vesting Schedule
Employee initial options grants	25% at one-year anniversary, 1/48 monthly thereafter
Employee recurring options grants	1/48 monthly
Non-employee consultant options grants	1/12 or 1/48 monthly
Employee RSUs	50% after one year, 50% after two years

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Year Ended December 31,
		2023				2022				2021
		(In thousands)
Continuing operations:
Research and development		$	4,754			$	6,123			$	6,791
Selling, general and administrative			7,140				8,042				8,154
Total stock-based compensation in continuing operations			11,894				14,165				14,945
Discontinued operations			(244	)			(93	)			2,685
Total stock-based compensation		$	11,650			$	14,072			$	17,630

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		Year Ended December 31,
		2023				2022				2021
Estimated weighted-average fair value		$	2.44			$	2.94			$	10.54
Weighted-average assumptions:
Expected volatility			93	%			90	%			81	%
Expected life, in years			7.2				6.0				6.0
Risk-free interest rate			3.97	%			2.83	%			1.06	%
Expected dividend yield			—	%			—	%			—	%

Share-Based Payment Arrangement, Activity [Table Text Block]

		Options Outstanding			Weighted- Average Exercise Price per Share			Remaining Contractual Life (In years)			Aggregate Intrinsic Value (In thousands)
Balance at December 31, 2022			13,872,973		$	11.02
Granted			3,153,200			3.01
Exercised			(36,726	)		4.10
Forfeited			(1,734,293	)		9.96
Balance at December 31, 2023			15,255,154		$	9.50			6.2		$	1,388
Vested and expected to vest at December 31, 2023			14,762,090		$	9.65			6.0		$	1,272
Exercisable at December 31, 2023			10,554,140		$	11.50			4.7		$	217

Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]

		RSUs Outstanding			Weighted- Average Grant Date Fair Value Per Share
Balance at December 31, 2022			98,750		$	7.53
Vested and released			(67,250	)		7.53
Forfeited			(31,500	)		7.53
Balance at December 31, 2023			—		$	—

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