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Note 1 - Organization and Basis of Presentation (Details Textual)
$ in Thousands
 1 Months Ended 12 Months Ended
Dec. 23, 2021
USD ($)
Feb. 29, 2024
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Mar. 01, 2021
USD ($)
Aug. 14, 2020
USD ($)
Proceeds from Divestiture of Businesses     $ 0 $ 0 $ 125,993    
Milestone Payment If Achieved Under Asset Purchase Agreement $ 200,000            
Milestone Period (Year) 4 years            
Milestone Payment Receivable     0 200,000      
Cash, Cash Equivalents, and Short-Term Investments     171,800        
Net Cash Provided by (Used in) Operating Activities     74,726 (86,483) (109,722)    
Net Income (Loss) Attributable to Parent     (117,813) 47,417 194,235    
Cash Proceeds From Milestone Payment     200,000        
Long-Term Debt, Gross     215,924 320,030      
Proceeds From Royalty Obligation     0 125,000 0    
Equity Offering Facility, Maximum Aggregate Offering Amount     $ 150,000     $ 150,000  
Number of Operating Segments     1        
Subsequent Event [Member]              
Proceeds From Royalty Obligation   $ 115,500          
Convertible Senior Notes 2023 [Member]              
Long-Term Debt, Gross     $ 95,000 $ 95,000     $ 95,000
Discontinued Operations, Disposed of by Sale [Member] | Omidria Assets Disposal [Member]              
Proceeds from Divestiture of Businesses $ 126,000       $ 125,993