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Note 13 - Income Taxes (Details Textual) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Discontinued Operation, Tax Effect of Discontinued Operation $ 462 $ 3,952 $ 1,006
Unrecognized Tax Benefits 1,966 212  
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued 300    
Unrecognized Tax Benefits that Would Impact Effective Tax Rate 1,800    
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense   0  
Research Tax Credit Carryforward [Member]      
Tax Credit Carryforward, Amount 93,000    
Omidria Assets Disposal [Member] | Discontinued Operations, Disposed of by Sale [Member]      
Discontinued Operation, Tax Effect of Discontinued Operation (462) (3,952) (1,006)
Domestic Tax Authority [Member]      
Operating Loss Carryforwards 398,600 361,400 630,600
Operating Loss Carryforwards Utilized 268,600 245,100  
Operating Loss Carryforwards Subject to Expiration 109,800    
Operating Loss Carryforwards Not Subject to Expiration 288,800    
State and Local Jurisdiction [Member]      
Operating Loss Carryforwards $ 245,800 226,300 245,100
State and Local Jurisdiction [Member] | Omidria Assets Disposal [Member] | Discontinued Operations, Disposed of by Sale [Member]      
Discontinued Operation, Tax Effect of Discontinued Operation   $ 4,000 $ 1,000