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Note 12 - Stock-based Compensation (Tables) | 9 Months Ended
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Sep. 30, 2024
Notes Tables |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Three Months Ended |  |  | Nine Months Ended |
​ |  | September 30, |  |  | September 30, |
​ |  | 2024 |  |  | 2023 |  |  | 2024 |  |  | 2023 |
​ |  | (In thousands) |  |  | (In thousands) |
Continuing operations |  | ​ |  |  | ​ |  |  | ​ |  |  | ​ |
Research and development |  | $ | 1,063 |  |  | $ | 1,305 |  |  | $ | 3,146 |  |  | $ | 3,710 |
Selling, general and administrative |  |  | 1,578 |  |  |  | 2,054 |  |  |  | 4,921 |  |  |  | 5,456 |
Total stock-based compensation in continuing operations |  |  | 2,641 |  |  |  | 3,359 |  |  |  | 8,067 |  |  |  | 9,166 |
Discontinued operations |  |  | — |  |  |  | (124 | ) |  |  | — |  |  |  | (207 | )
Total stock-based compensation |  | $ | 2,641 |  |  | $ | 3,235 |  |  | $ | 8,067 |  |  | $ | 8,959 |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
​ |  | Three Months Ended |  |  | Nine Months Ended |
​ |  | September 30, 2024 |  |  | September 30, 2024 |
Estimated weighted-average fair value |  | $ | 3.06 |  |  | $ | 2.60 |
Weighted-average assumptions: |  | ​ |  |  | ​ |
Expected volatility |  |  | 96 | % |  |  | 95 | %
Expected life, in years |  |  | 7.4 |  |  |  | 7.2 |
Risk-free interest rate |  |  | 4.22 | % |  |  | 4.36 | %
Expected dividend yield |  |  | — | % |  |  | — | %
Share-Based Payment Arrangement, Activity [Table Text Block] |
​ |  | ​ |  |  | Weighted- |  |  | ​ |  |  | ​ |
​ |  | ​ |  |  | Average |  |  | ​ |  |  | Aggregate |
​ |  | ​ |  |  | Exercise |  |  | Remaining |  |  | Intrinsic |
​ |  | Options |  |  | Price per |  |  | Contractual Life |  |  | Value |
​ |  | Outstanding |  |  | Share |  |  | (In years) |  |  | (In thousands) |
Balance at December 31, 2023 |  |  | 15,255,154 |  |  | $ | 9.50 |  |  |  |  |  |  |  |  |
Granted |  |  | 3,280,500 |  |  |  | 3.13 |  |  |  |  |  |  |  |  |
Exercised |  |  | (16,404 | ) |  |  | 3.19 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (386,181 | ) |  |  | 6.91 |  |  |  |  |  |  |  |  |
Balance at September 30, 2024 |  |  | 18,133,069 |  |  | $ | 8.41 |  |  |  | 6.0 |  |  | $ | 6,168 |
Vested and expected to vest at September 30, 2024 |  |  | 17,503,959 |  |  | $ | 8.58 |  |  |  | 5.9 |  |  | $ | 5,677 |
Exercisable at September 30, 2024 |  |  | 12,133,698 |  |  | $ | 10.75 |  |  |  | 4.5 |  |  | $ | 1,421 |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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