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Condensed Consolidated Statements of Stockholders’ Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Deficit
Accumulated Other Comprehensive Loss
Beginning balance (in shares) at Dec. 31, 2021   142,623,065      
Beginning balance at Dec. 31, 2021 $ 916,406 $ 142 $ 1,822,179 $ (903,348) $ (2,567)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock upon exercise of stock options and vesting of RSUs (in shares)   715,961      
Issuance of common stock upon exercise of stock options and vesting of RSUs 283 $ 1 282    
Vesting of early exercised common stock 1,228   1,228    
Stock-based compensation 22,315   22,315    
Employee stock purchase plan (in shares)   230,876      
Employee stock purchase plan 1,530   1,530    
Net loss (79,850)     (79,850)  
Net unrealized gain (loss) on available-for-sale investments (6,682)       (6,682)
Ending balance (in shares) at Mar. 31, 2022   143,569,902      
Ending balance at Mar. 31, 2022 855,230 $ 143 1,847,534 (983,198) (9,249)
Beginning balance (in shares) at Dec. 31, 2021   142,623,065      
Beginning balance at Dec. 31, 2021 916,406 $ 142 1,822,179 (903,348) (2,567)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (237,785)        
Net unrealized gain (loss) on available-for-sale investments (10,391)        
Ending balance (in shares) at Sep. 30, 2022   144,031,588      
Ending balance at Sep. 30, 2022 739,961 $ 144 1,893,908 (1,141,133) (12,958)
Beginning balance (in shares) at Mar. 31, 2022   143,569,902      
Beginning balance at Mar. 31, 2022 855,230 $ 143 1,847,534 (983,198) (9,249)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock upon exercise of stock options and vesting of RSUs (in shares)   153,269      
Issuance of common stock upon exercise of stock options and vesting of RSUs 25 $ 1 24    
Vesting of early exercised common stock 813   813    
Stock-based compensation 22,891   22,891    
Net loss (74,787)     (74,787)  
Net unrealized gain (loss) on available-for-sale investments (2,223)       (2,223)
Ending balance (in shares) at Jun. 30, 2022   143,723,171      
Ending balance at Jun. 30, 2022 801,949 $ 144 1,871,262 (1,057,985) (11,472)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock upon exercise of stock options and vesting of RSUs (in shares)   177,678      
Issuance of common stock upon exercise of stock options and vesting of RSUs 135   135    
Vesting of early exercised common stock 432   432    
Stock-based compensation 21,148   21,148    
Employee stock purchase plan (in shares)   130,739      
Employee stock purchase plan 931   931    
Net loss (83,148)     (83,148)  
Net unrealized gain (loss) on available-for-sale investments (1,486)       (1,486)
Ending balance (in shares) at Sep. 30, 2022   144,031,588      
Ending balance at Sep. 30, 2022 $ 739,961 $ 144 1,893,908 (1,141,133) (12,958)
Beginning balance (in shares) at Dec. 31, 2022 144,438,304 144,438,304      
Beginning balance at Dec. 31, 2022 $ 665,870 $ 144 1,911,632 (1,235,980) (9,926)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock upon exercise of stock options and vesting of RSUs (in shares)   942,276      
Issuance of common stock upon exercise of stock options and vesting of RSUs 0 $ 1 (1)    
Vesting of early exercised common stock 603   603    
Stock-based compensation 18,770   18,770    
Employee stock purchase plan (in shares)   359,753      
Employee stock purchase plan 1,731 $ 1 1,730    
Net loss (98,704)     (98,704)  
Net unrealized gain (loss) on available-for-sale investments 3,992       3,992
Ending balance (in shares) at Mar. 31, 2023   145,740,333      
Ending balance at Mar. 31, 2023 $ 592,262 $ 146 1,932,734 (1,334,684) (5,934)
Beginning balance (in shares) at Dec. 31, 2022 144,438,304 144,438,304      
Beginning balance at Dec. 31, 2022 $ 665,870 $ 144 1,911,632 (1,235,980) (9,926)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (238,008)        
Net unrealized gain (loss) on available-for-sale investments $ 7,515        
Ending balance (in shares) at Sep. 30, 2023 168,175,221 168,175,221      
Ending balance at Sep. 30, 2023 $ 583,102 $ 168 2,059,333 (1,473,988) (2,411)
Beginning balance (in shares) at Mar. 31, 2023   145,740,333      
Beginning balance at Mar. 31, 2023 592,262 $ 146 1,932,734 (1,334,684) (5,934)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock from ATM offering, net of commissions and offering costs (in shares)   20,288,330      
Issuance of common stock from ATM offering, net of commissions and offering costs 87,918 $ 20 87,898    
Issuance of common stock upon exercise of stock options and vesting of RSUs (in shares)   1,105,001      
Issuance of common stock upon exercise of stock options and vesting of RSUs 1,606 $ 1 1,605    
Vesting of early exercised common stock 432   432    
Stock-based compensation 16,594   16,594    
Net loss (77,989)     (77,989)  
Net unrealized gain (loss) on available-for-sale investments 2,083       2,083
Ending balance (in shares) at Jun. 30, 2023   167,133,664      
Ending balance at Jun. 30, 2023 622,906 $ 167 2,039,263 (1,412,673) (3,851)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock from ATM offering, net of commissions and offering costs (in shares)   606,235      
Issuance of common stock from ATM offering, net of commissions and offering costs 3,194 $ 1 3,193    
Issuance of common stock upon exercise of stock options and vesting of RSUs (in shares)   204,116      
Issuance of common stock upon exercise of stock options and vesting of RSUs 326 $ 0 326    
Vesting of early exercised common stock 432   432    
Stock-based compensation 15,354   15,354    
Employee stock purchase plan (in shares)   231,206      
Employee stock purchase plan 765 $ 0 765    
Net loss (61,315)     (61,315)  
Net unrealized gain (loss) on available-for-sale investments $ 1,440       1,440
Ending balance (in shares) at Sep. 30, 2023 168,175,221 168,175,221      
Ending balance at Sep. 30, 2023 $ 583,102 $ 168 $ 2,059,333 $ (1,473,988) $ (2,411)