    <SEC-DOCUMENT>0001104659-25-024021-index.html : 20250314
    <SEC-HEADER>0001104659-25-024021.hdr.sgml : 20250314
    <ACCEPTANCE-DATETIME>20250314171600
    ACCESSION NUMBER:		0001104659-25-024021
    CONFORMED SUBMISSION TYPE:	S-4/A
    PUBLIC DOCUMENT COUNT:		35
    FILED AS OF DATE:		20250314
    DATE AS OF CHANGE:		20250314

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Aerovate Therapeutics, Inc.
    		CENTRAL INDEX KEY:			0001798749
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		IRS NUMBER:				831377888
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-4/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-283562
    		FILM NUMBER:		25741296

    	BUSINESS ADDRESS:
    		STREET 1:		930 WINTER STREET
    		STREET 2:		SUITE M-500
    		CITY:			WALTHAM
    		STATE:			MA
    		ZIP:			02451
    		BUSINESS PHONE:		617-443-2400

    	MAIL ADDRESS:
    		STREET 1:		930 WINTER STREET
    		STREET 2:		SUITE M-500
    		CITY:			WALTHAM
    		STATE:			MA
    		ZIP:			02451
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-4/A
    <SEQUENCE>1
    <FILENAME>tm253007-7_s4a.htm
    <DESCRIPTION>S-4/A
    <TEXT>
    Document 1 - file: tm253007-7_s4a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>2
    <FILENAME>tm253007d9_ex5-1.htm
    <DESCRIPTION>EXHIBIT 5.1
    <TEXT>
    Document 2 - file: tm253007d9_ex5-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-8.1
    <SEQUENCE>3
    <FILENAME>tm253007d9_ex8-1.htm
    <DESCRIPTION>EXHIBIT 8.1
    <TEXT>
    Document 3 - file: tm253007d9_ex8-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-8.2
    <SEQUENCE>4
    <FILENAME>tm253007d9_ex8-2.htm
    <DESCRIPTION>EXHIBIT 8.2
    <TEXT>
    Document 4 - file: tm253007d9_ex8-2.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.6
    <SEQUENCE>5
    <FILENAME>tm253007d9_ex10-6.htm
    <DESCRIPTION>EXHIBIT 10.6
    <TEXT>
    Document 5 - file: tm253007d9_ex10-6.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>6
    <FILENAME>tm253007d9_ex23-1.htm
    <DESCRIPTION>EXHIBIT 23.1
    <TEXT>
    Document 6 - file: tm253007d9_ex23-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.2
    <SEQUENCE>7
    <FILENAME>tm253007d9_ex23-2.htm
    <DESCRIPTION>EXHIBIT 23.2
    <TEXT>
    Document 7 - file: tm253007d9_ex23-2.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.3
    <SEQUENCE>8
    <FILENAME>tm253007d9_ex23-3.htm
    <DESCRIPTION>EXHIBIT 23.3
    <TEXT>
    Document 8 - file: tm253007d9_ex23-3.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-FILING FEES
    <SEQUENCE>9
    <FILENAME>tm253007d9_ex-filingfees.htm
    <DESCRIPTION>EX-FILING FEES
    <TEXT>
    Document 9 - file: tm253007d9_ex-filingfees.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>bc_clinical-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 10 - file: bc_clinical-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>bc_sibeprenlimab-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: bc_sibeprenlimab-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>fc_baff-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: fc_baff-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>fc_jademabs-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 13 - file: fc_jademabs-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>fc_novel-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 14 - file: fc_novel-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>fc_plasma-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 15 - file: fc_plasma-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>ft_lucid-bw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 16 - file: ft_lucid-bw.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>lc_human-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 17 - file: lc_human-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>18
    <FILENAME>lc_igan-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 18 - file: lc_igan-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>19
    <FILENAME>lc_reduction-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 19 - file: lc_reduction-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>lc_sibeprenlimab-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 20 - file: lc_sibeprenlimab-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>lc_treatment-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 21 - file: lc_treatment-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>22
    <FILENAME>lc_upcr-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 22 - file: lc_upcr-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>23
    <FILENAME>lg_aerovate-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 23 - file: lg_aerovate-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>24
    <FILENAME>lg_jade-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 24 - file: lg_jade-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>25
    <FILENAME>lg_lucid-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 25 - file: lg_lucid-4c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>26
    <FILENAME>px_aerovatecommon25pg01-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 26 - file: px_aerovatecommon25pg01-4c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>27
    <FILENAME>px_aerovatecommon25pg02-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 27 - file: px_aerovatecommon25pg02-4c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>28
    <FILENAME>sg_lucidcapital-bw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 28 - file: sg_lucidcapital-bw.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>29
    <FILENAME>tb_acei-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 29 - file: tb_acei-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>30
    <FILENAME>tb_belimumab-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 30 - file: tb_belimumab-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>31
    <FILENAME>tb_taci-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 31 - file: tb_taci-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>32
    <FILENAME>tm253007d9_ex8-1img001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 32 - file: tm253007d9_ex8-1img001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>33
    <FILENAME>tm253007d9_ex8-1img002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 33 - file: tm253007d9_ex8-1img002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>34
    <FILENAME>tm253007d9_ex5-1img001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 34 - file: tm253007d9_ex5-1img001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>35
    <FILENAME>tm253007d9_ex5-1img01.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 35 - file: tm253007d9_ex5-1img01.jpg

    </DOCUMENT>
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