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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Cash flows from operating activities |  |  |
Net income | $ 23,337 | $ 115,553 | $ 25,208
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Depreciation of property and equipment | 1,386 | 1,387 | 1,429
Stock-based compensation | 13,360 | 13,458 | 11,666
Amortization of premiums and accretion of discounts on marketable securities | 179 | (3,099) | (2,221)
Gain on sale of marketable securities | (229) | 0 | 0
Intangible asset amortization | 1,478 | 1,505 | 1,527
Deferred income taxes | 6,189 | (87,767) | 0
Other non-cash adjustments, net | 1,758 | 1,785 | 167
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (3,767) | 2,342 | (11,207)
Prepaid expenses and other assets | 4,068 | (2,764) | (4,258)
Inventory | (2,876) | (722) | 70
Accounts payable and other liabilities | 3,759 | 3,508 | (618)
Product revenue allowances | 3,133 | 761 | 8,223
Net cash provided by operating activities | 51,775 | 45,947 | 29,986
Cash flows from investing activities |  |  |
Acquisition of intangible asset | 0 | 0 | (25,000)
Purchases of property and equipment | (1,795) | (1,019) | (368)
Purchases of marketable securities | (346,622) | (394,517) | (282,395)
Sales and maturities of marketable securities | 306,918 | 327,227 | 198,103
Net cash used in investing activities | (41,499) | (68,309) | (109,660)
Cash flows from financing activities |  |  |
Net proceeds from offering of common stock | 0 | 0 | 100,870
Proceeds from exercise of stock options | 5,634 | 6,264 | 6,256
Net cash provided by financing activities | 5,634 | 6,264 | 107,126
Effect of exchange rate changes on cash, cash equivalents and restricted cash | 53 | (1) | (38)
Net change in cash, cash equivalents and restricted cash | 15,963 | (16,099) | 27,414
Cash, cash equivalents and restricted cash |  |  |
Beginning of year | 45,650 | 61,749 | 34,335
End of year | $ 61,613 | $ 45,650 | $ 61,749

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