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Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2020 | Dec. 31, 2019
Income Taxes [Line Items] |  |
Net operating loss carryforwards | $ 43,623 | $ 52,034
Deferred tax assets related to U.S. federal research and development credits | $ 13,400 |
Net operating loss carryforwards beginning expiration year | 2031 |
U.S. research and development credit beginning expiration year | 2024 |
Orphan drug credit beginning expiration year | 2030 |
Deferred tax assets relating to U.S. state NOL carryforwards | $ 8,400 |
Unrecognized tax benefits that would impact effective tax rate | 11,200 |
U.S. Federal |  |
Income Taxes [Line Items] |  |
Net operating loss carryforwards | 35,200 |
Orphan Drug |  |
Income Taxes [Line Items] |  |
Net deferred tax assets | $ 24,400 |
District of Columbia |  |
Income Taxes [Line Items] |  |
Net operating loss carryforwards beginning expiration year | 2032 |
Other States |  |
Income Taxes [Line Items] |  |
Net operating loss carryforwards beginning expiration year | 2029 |

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