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Income Taxes - Components of Net Deferred Tax Assets and Related Valuation Allowance (Detail) - USD ($) $ in Thousands | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | --- | --- | ---
Deferred tax assets: |  |  |  |
Net operating loss carryforwards | $ 43,623 | $ 52,034 |  |
Stock-based compensation | 4,653 | 5,298 |  |
Accrued expenses | 2,429 | 1,266 |  |
Allowance for returns and credit losses | 1,169 | 1,468 |  |
Research and development and orphan drug credit carryforwards | 37,737 | 36,041 |  |
Other | 3,279 | 4,572 |  |
Total deferred tax assets | 92,890 | 100,679 |  |
Deferred tax liabilities: |  |  |  |
Intangible assets | (1,911) | (1,994) |  |
Other | (2,412) | (2,850) |  |
Total deferred tax liabilities | (4,323) | (4,844) |  |
Deferred tax assets, net | 88,567 | 95,835 |  |
Less: Valuation allowance | 7,051 | 8,155 | $ 111,950 | $ 116,110
Net deferred tax assets | $ 81,516 | $ 87,680 |  |

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