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Commitments and Contingencies - CFTR Activators and Inhibitors - Additional Information (Detail) - USD ($)
$ in Thousands
 1 Months Ended 12 Months Ended 46 Months Ended
Mar. 31, 2019
Dec. 31, 2020
Dec. 31, 2020
Dec. 31, 2019
CFTR activators and inhibitors        
Milestone obligations under license agreements   $ 350 $ 350 $ 0
CFTR Activators and Inhibitors        
CFTR activators and inhibitors        
Tiered royalties payable on future net sales   single-digit    
Development and milestone payments to third party     1,200  
Regulatory Approval Milestone | CFTR Activators and Inhibitors        
CFTR activators and inhibitors        
Possible future milestone payments   $ 12,200    
Future Regulatory Approval And Sales Milestones | CFTR Activators and Inhibitors        
CFTR activators and inhibitors        
Possible future milestone payments   33,000    
Development And Milestone Payment, Conclusion Of Phase I Study | CFTR Activators and Inhibitors        
CFTR activators and inhibitors        
Development and milestone payments to third party $ 200      
Possible future milestone payments   350    
Milestone obligations under license agreements   350 $ 350  
Maximum | Development And Milestone Payment, Conclusion Of Phase I Study | CFTR Activators and Inhibitors        
CFTR activators and inhibitors        
Possible future milestone payments   $ 1,100