<DOCUMENT>
<TYPE>EX-32.1
<SEQUENCE>5
<FILENAME>iss120432-1.txt
<DESCRIPTION>CERTIFICATION
<TEXT>

Exhibit 32.1

                                  CERTIFICATION


I, Ramesh C. Trivedi, Chief Executive Officer of Integrated Surgical Systems,
Inc. (the "Company"), hereby certify, pursuant to 18 U.S.C. Section 1350, as
adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

     1.   The Annual Report on Form 10-KSB of the Company for the year ended
          December 31, 2004, which this certification accompanies (the "Periodic
          Report"), fully complies with the requirements of Section 13(a) of the
          Securities Exchange Act of 1934; and

     2.   The information contained in the Periodic Report fairly presents, in
          all material respects, the financial condition and results of
          operations of the Company.



Dated: April 15, 2005                        /s/ Ramesh C. Trivedi
                                             ---------------------
                                             Ramesh C. Trivedi
                                             Chief Executive Officer

</TEXT>
</DOCUMENT>
