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Proc-Type: 2001,MIC-CLEAR
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<SEC-DOCUMENT>0001108890-06-000294.txt : 20060808
<SEC-HEADER>0001108890-06-000294.hdr.sgml : 20060808
<ACCEPTANCE-DATETIME>20060808121839
ACCESSION NUMBER:		0001108890-06-000294
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060804
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Other Events
FILED AS OF DATE:		20060808
DATE AS OF CHANGE:		20060808

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			INTEGRATED SURGICAL SYSTEMS INC
		CENTRAL INDEX KEY:			0000894871
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				680232575
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-12471
		FILM NUMBER:		061011925

	BUSINESS ADDRESS:	
		STREET 1:		1850 RESEARCH PARK DR
		CITY:			DAVIS
		STATE:			CA
		ZIP:			95616-4884
		BUSINESS PHONE:		5307922600

	MAIL ADDRESS:	
		STREET 1:		1850 RESEARCH PARK
		CITY:			DAVIS
		STATE:			CA
		ZIP:			95616-4884
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>integrated8k080306.txt
<DESCRIPTION>PERIOD ENDED 08-04-06
<TEXT>



                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                             CURRENT REPORT PURSUANT
                          TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

         Date of report (Date of earliest event reported): August 4, 2006

                        INTEGRATED SURGICAL SYSTEMS, INC.
         ---------------------------------------------------------------
        (Exact name of small Business Issuer as specified in its charter)


          Delaware                   1-12471                      68-0232575
 ---------------------------        ----------                   ------------
(State or other jurisdiction       (Commission                  (IRS Employer
      of incorporation)            File Number)              Identification No.)


             6220 Belleau Wood Lane, Suite 4, Sacramento, California    95822
                     --------------------------------------            --------
                    (Address of principal executive offices)          (Zip Code)

Registrant's telephone number, including area code (916) 391-0450

                                       N/A
           -----------------------------------------------------------
          (Former name or former address, if changes since last report)

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

[ ]  Written communications pursuant to Rule 425 under the Securities Act (17
     CFR 230.425)

[ ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
     CFR 240.14a-12)

[ ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

[ ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))

<PAGE>


Item 1.01.    Entry into a Material Definitive Agreement.

On August 4, 2006, the Registrant entered into an Asset Purchase Agreement with
Novatrix Biomedical, Inc. ("Novatrix") pursuant to which the Registrant has
agreed to sell substantially all of its assets to Novatrix (the "Asset Purchase
Agreement"). The aggregate purchase price for the sale of the assets is
$4,000,000, half of which is to be paid at the closing and the remaining half of
which is to be paid upon the earlier to occur of March 1, 2008 or the date on
which the Registrant receives 510(k) clearance from the U.S. Food & Drug
Administration for its ROBODOC Surgical Assist System. Consummation of the
transaction is subject to approval of the Registrant's stockholders as well as
other customary closing conditions.

Also on August 4, 2006, the Registrant and Novatrix entered into a Loan
Agreement and Secured Promissory Note (the "Loan Agreement") pursuant to which
Novatrix has agreed to loan to the Registrant up to $6 million as follows:

     o    $2.7 million upon the execution of the Loan Agreement

     o    $3.3 million in two tranches upon reaching certain milestones

The Loan Agreement provides that upon the consummation of the sale of assets
contemplated by the Asset Purchase Agreement, Novatrix will convert any
outstanding obligations to advance funds to the Registrant into obligations of
Novatrix to fund its own working capital in equal amounts for the purpose of
developing the ROBODOC and ORTHODOC products. In addition, the Loan Agreement
provides that upon the approval by the Registrant's stockholders of the asset
sale, all obligations of the Registrant to repay amounts owing under the Loan
Agreement shall be extinguished.

The Loan Agreement further provides that in the event that approval by the
Registrant's stockholders of the asset sale does not occur by June 30, 2007, the
Registrant shall grant an exclusive license in the Asian markets of its ROBODOC
Surgical Assitant System to Novatrix in exchange for a one-time royalty payment
of $100,000.

Simultaneously with the execution and delivery of the Asset Purchase Agreement
and Loan Agreement, the parties entered into a Security Agreement pursuant to
which the Registrant granted a security interest in its assets to Novatrix as
security for repayment of the Registrant's obligations under the Loan Agreement.

Item 8.01.    Other Events.

On August 4, 2006, as required by the Loan Agreement, the Registrant reached a
settlement with over 80% of its outstanding creditors pursuant to which each
such creditor agreed to extinguish all outstanding debts of the Registrant owed
thereto in exchange for a payment by the Registrant to each such creditor of
17.6 cents for each dollar owed.

The Registrant is presently in the process of seeking new accountants to audit
its financial statements and upon the retention thereof, the Registrant intends
to complete and file with the Securities and Exchange Commission all past due
required filings under the Securities Exchange Act of 1934.

                                       2

<PAGE>


                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                            Integrated Surgical Systems, Inc.
                                                     (Registrant)


Dated:  August 8, 2006                      By:  /s/  Ramesh Trivedi
                                               --------------------------------
                                                      Ramesh Trivedi,
                                                      Chief Executive Officer

                                       3
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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