-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
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<SEC-DOCUMENT>0001000096-07-000166.txt : 20070425
<SEC-HEADER>0001000096-07-000166.hdr.sgml : 20070425
<ACCEPTANCE-DATETIME>20070425133403
ACCESSION NUMBER:		0001000096-07-000166
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20070423
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20070425
DATE AS OF CHANGE:		20070425

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			INTEGRATED SURGICAL SYSTEMS INC
		CENTRAL INDEX KEY:			0000894871
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				680232575
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-12471
		FILM NUMBER:		07786925

	BUSINESS ADDRESS:	
		STREET 1:		1433 N. MARKET BLVD.
		STREET 2:		SUITE 1
		CITY:			SACRAMENTO
		STATE:			CA
		ZIP:			95834
		BUSINESS PHONE:		916-285-9943

	MAIL ADDRESS:	
		STREET 1:		1433 N. MARKET BLVD.
		STREET 2:		SUITE 1
		CITY:			SACRAMENTO
		STATE:			CA
		ZIP:			95834
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>integrated8k4232007.txt
<DESCRIPTION>FORM 8-K  (4-23-2007)
<TEXT>



                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                             CURRENT REPORT PURSUANT
                          TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

        Date of report (Date of earliest event reported): April 23, 2007

                        INTEGRATED SURGICAL SYSTEMS, INC.
        (Exact name of small Business Issuer as specified in its charter)

          Delaware                    1-12471                   68-0232575
- --------------------------------------------------------------------------------
(State or other jurisdiction        (Commission               (IRS Employer
     of incorporation)             File Number)            Identification No.)

  1433 N. Freeway Blvd., Suite 1, Sacramento, California          95834
- --------------------------------------------------------------------------------
         (Address of principal executive offices)               (Zip Code)

Registrant's telephone number, including area code (916) 285-9943
                                                   --------------

                                       N/A
- --------------------------------------------------------------------------------
          (Former name or former address, if changes since last report)

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

[ ]      Written communications pursuant to Rule 425 under the Securities
         Act (17 CFR 230.425)

[ ]      Soliciting material pursuant to Rule 14a-12 under the Exchange Act
         (17 CFR 240.14a-12)

[ ]      Pre-commencement communications pursuant to Rule 14d-2(b) under the
         Exchange Act (17 CFR 240.14d-2(b))

[ ]      Pre-commencement communications pursuant to Rule 13e-4(c) under the
         Exchange Act (17 CFR 240.13e-4(c))

<PAGE>


Item 1.01.        Entry into a Material Definitive Agreement.

On April 23, 2007, the Registrant entered into amendments to each of the Asset
Purchase Agreement ("Amended APA") and Loan Agreement and Secured Promissory
Note ("Amended Loan Agreement") with Novatrix Biomedical, Inc. ("Novatrix"). The
Amended APA provides that the purchase price for the sale of substantially all
of the assets of the Registrant to Novatrix will be paid at the closing and the
amount of consideration will vary depending upon when stockholder approval of
the transaction is obtained. In the event that stockholder approval is obtained
on or before June 30, 2007, the consideration will be $4 million; after June 30
but on or before July 31, 2007, $3.5 million; after July 31 but on or before
August 31, 2007, $3.25 million; and after August 31 but on or before September
30, 2007, $3 million. The original asset purchase agreement had provided that
the Registrant would receive $2 million of the consideration at closing, and the
remaining $2 million upon the earlier to occur of March 1, 2008 or the date on
which the Registrant receives 510(k) clearance from the U.S. Food & Drug
Administration for its ROBODOC Surgical Assist System. Further, the Amended APA
modifies the date after which Novatrix can terminate the Asset Purchase
Agreement from June 30, 2007 to September 30, 2007.

The Amended Loan Agreement extends, from June 30, 2007 to September 30, 2007,
the deadline for the Registrant to obtain stockholder approval for the asset
transaction in order to avoid being obligated to grant an exclusive license to
Novatrix in the Asian markets for the Registrant's ROBODOC and ORTHODOC systems.
It also reduces the time, from six months to three months, that the Registrant
has to repay outstanding loans due to Novatrix in the event that stockholder
approval is not obtained. Further, the Amended Loan Agreement reduces the
obligation of Novatrix to loan additional funds to the Registrant from $2.3
million to $350,000 per month commencing July 1, 2007 and the first day of each
successive month thereafter until the earlier of (i) September 1, 2007 or (ii)
such time as stockholder approval has been obtained.

Item 9.01.        Financial Statements and Exhibits.

(c)  Exhibits

Exhibit
Number          Description
- ------          -----------

10.1            Amendment to Loan Agreement and Secured Promissory Note, dated
                April 23, 2007.

10.2            Amendment to Asset Purchase Agreement, dated April 23, 2007.


                                       2
<PAGE>


                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                     Integrated Surgical Systems, Inc.
                                     (Registrant)


Dated:  April 23, 2007               By:  /s/  Ramesh Trivedi
                                          --------------------------------------
                                               Ramesh Trivedi,
                                               Chief Executive Officer


                                       3
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>2
<FILENAME>form8k4232007exh101.txt
<DESCRIPTION>AMENDMENT TO LOAN AGREEMENT
<TEXT>


                                                                    Exhibit 10.1


                                  AMENDMENT TO

                   LOAN AGREEMENT AND SECURED PROMISSORY NOTE


     AMENDED AGREEMENT dated as of April 23, 2007 by and between Integrated
Surgical Systems, Inc., a Delaware corporation ("ISS"), and Novatrix Biomedical,
Inc., a California corporation ("Novatrix").

     WHEREAS, the parties entered into that certain Loan Agreement and Secured
Promissory Note dated August 4, 2006 (the "Original Loan Agreement");

     WHEREAS, the parties are simultaneously entering into an amendment to that
certain Asset Purchase Agreement dated August 4, 2006; and

     WHEREAS, the parties wish to amend the Original Loan Agreement as set forth
herein.

     NOW, THEREFORE, the parties hereby agree as follows:

     1.   Paragraph (a) of the Original Loan Agreement is hereby amended to
          replace the words "June 30, 2007" in the first line thereof in their
          entirety with the words "September 30, 2007."

     2.   Section 1.3 of the Original Loan Agreement is hereby amended in its
          entirety to read as follows:

               "$350,000 per month payable commencing on July 1, 2007 and the
               first day of each successive month thereafter until the earlier
               of (i) September 1, 2007 or (ii) such time as Stockholder
               Approval has been obtained."

     3.   Section 9.1 of the Original Loan Agreement is hereby amended in its
          entirety to read as follows:

               "Borrower fails to pay timely any of the principal amount due
               under this Note or any accrued interest or other amounts due
               under this Note within three (3) months from the date of a
               meeting of the stockholders of Borrower in which Stockholder
               Approval is not obtained; or"

     4.   This Agreement shall be construed in accordance with, and governed in
          all respects by, the internal laws of the State of California (without
          giving effect to principles of conflicts of laws).

<PAGE>


     5.   This Agreement may be executed in counterparts, each of which shall be
          deemed an original, and all of which, when taken together, shall
          constitute one and the same instrument.

     6.   Any and all terms and provisions contained in the Original Loan
          Agreement not otherwise amended pursuant to this Agreement shall
          remain in full force and effect in accordance with the terms thereof.

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the
first day set forth above.

                                            INTEGRATED SURGICAL SYSTEMS, INC.



                                            By: /s/ Ramesh Trivedi
                                                --------------------------------
                                                Name:    Ramesh Trivedi
                                                Title:   Chief Executive Officer



                                            NOVATRIX BIOMEDICAL, INC.




                                            By: /s/ Soonkap Hahn
                                                --------------------------------
                                                Name:    Soonkap Hahn
                                                Title:   President


                                       2




</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.2
<SEQUENCE>3
<FILENAME>form8k4232007exh102.txt
<DESCRIPTION>AMENDMENT TO ASSET PURCHASE AGREEMENT
<TEXT>

                                                                    Exhibit 10.2


                                  AMENDMENT TO

                            ASSET PURCHASE AGREEMENT


     AMENDED AGREEMENT dated as of April 23, 2007 by and between Integrated
Surgical Systems, Inc., a Delaware corporation ("ISS"), and Novatrix Biomedical,
Inc., a California corporation ("Novatrix").

     WHEREAS, the parties entered into that certain Asset Purchase Agreement
dated August 4, 2006 (the "Original Asset Purchase Agreement");

     WHEREAS, the parties are simultaneously entering into an amendment to that
certain Loan Agreement and Secured Promissory Note dated August 4, 2006; and

     WHEREAS, the parties wish to amend the Original Asset Purchase Agreement as
set forth herein.

     NOW, THEREFORE, the parties hereby agree as follows:

     1.   Section 1.2 of the Original Asset Purchase Agreement is hereby amended
          in its entirety to read as follows:

          "1.2 Purchase Price

          As consideration for the sale of the Assets to the Purchaser, at the
          Closing, the Purchaser shall pay to the Seller, in cash, an amount
          equal to

          (i)  $4 million in the event that Stockholder Approval (as such term
               is defined in that certain Loan Agreement and Secured Promissory
               Note dated August 4, 2006 by and between the Purchaser and the
               Seller) is obtained on or before June 30, 2007;

          (ii) $3.5 million in the event that Stockholder Approval is obtained
               on or before July 31, 2007;

          (iii) $3.25 million in the event that Stockholder Approval is obtained
               on or before August 31, 2007; or

          (iv) $3 million in the event that Stockholder Approval is obtained on
               or before September 30, 2007."

     2.   Section 1.4(b)(ii) of the Original Asset Purchase Agreement is hereby
          amended in its entirety to read as follows:

<PAGE>


               "(ii) the Purchaser shall pay to the Seller in cash by wire
               transfer of immediately available funds to an account or accounts
               designated by the Seller the amount set forth in either Section
               1.2(i), (ii), (iii) or (iv), as applicable."

     3.   Section 8.1(c) of the Original Asset Purchase Agreement is hereby
          amended by replacing the words "June 30, 2007" in the second line
          thereof with the words "September 30, 2007."

     4.   This Agreement shall be construed in accordance with, and governed in
          all respects by, the internal laws of the State of California (without
          giving effect to principles of conflicts of laws).

     5.   This Agreement may be executed in counterparts, each of which shall be
          deemed an original, and all of which, when taken together, shall
          constitute one and the same instrument.

     6.   Any and all terms and provisions contained in the Original Asset
          Purchase Agreement not otherwise amended pursuant to this Agreement
          shall remain in full force and effect in accordance with the terms
          thereof.

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the
first day set forth above.

                                            INTEGRATED SURGICAL SYSTEMS, INC.



                                            By: /s/ Ramesh Trivedi
                                                --------------------------------
                                                Name:    Ramesh Trivedi
                                                Title:   Chief Executive Officer



                                            NOVATRIX BIOMEDICAL, INC.




                                            By: /s/ Soonkap Hahn
                                               ---------------------------------
                                               Name:    Soonkap Hahn
                                               Title:   President


                                       2
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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