<DOCUMENT>
<TYPE>DEFA14A
<SEQUENCE>1
<FILENAME>isspxya1.txt
<DESCRIPTION>DEFA14A
<TEXT>

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 14A

           Proxy Statement Pursuant to Section 14(a) of the Securities
                     Exchange Act of 1934 (Amendment No. 1)


Filed by the Registrant [X]      Filed by a Party other than Registrant [ ]

Check the appropriate box:

[ ] Preliminary Proxy Statement
[ ] Confidential, for Use of the Commission Only (as permitted by Rule
    14a-6(e)(2))
[ ] Definitive Proxy Statement
[X] Definitive Additional Materials
[ ] Soliciting Material Pursuant to Section 240.14a-12


                        Integrated Surgical Systems, Inc.
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                (Name of Registrant as Specified In Its Charter)


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    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X] No fee required
[ ] Fee computed on table below per Exchange Act Rules 14a-6(I)(4) and 0-11.

     1)   Title of each class of securities to which transaction applies:

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     2)   Aggregate number of securities to which transaction applies:

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     3)   Per unit price or other underlying value of transaction computed
          pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
          filing fee is calculated and state how it was determined):

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     4)   Proposed maximum aggregate value of transaction:

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     5)   Total fee paid:

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[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by Exchange Act Rule
    0-11(a)(2) and identify the filing for which the offsetting fee was paid
    previously. Identify the previous filing by registration statement number,
    or the Form or Schedule and the date of its filing.

     1)   Amount Previously Paid:

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     2)   Form, Schedule or Registration Statement No.:

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     3)   Filing Party:

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     4)   Date Filed:

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<PAGE>

                        Integrated Surgical Systems, Inc.
                          1433 N. Market Blvd., Suite 1
                          Sacramento, California 95834

                                                                   June 11, 2007

Dear Shareholder:

As you know, we will hold our Annual Meeting of Stockholders on June 28, 2007.
Accompanying this letter is a supplement to the May 25, 2007 Proxy Statement
that we previously sent you concerning the Annual Meeting. Please note that this
supplement should be read in conjunction with the Proxy Statement and the Notice
of Annual Meeting of Stockholders that we distributed with the Proxy Statement.
If you would like another copy of the Proxy Statement, you may obtain a copy
free of charge by calling us at (916) 285-9943.

You may vote or change your vote as described on page 1 of the Proxy Statement.
Please note that the proxy card included in the original Proxy Statement remains
unchanged. Any proxies that we received in response to the original solicitation
made pursuant to the Proxy Statement and that are not revoked will remain valid
for the purposes stated for the Annual Meeting. Any proxy previously submitted
may be revoked by a subsequently delivered proxy. To vote by proxy, please
complete, sign, date and return the proxy card that accompanied the original
Proxy Statement.
                                            Sincerely,


                                            /s/ Ramesh C. Trivedi
                                            ---------------------
                                            Ramesh C. Trivedi
                                            Chairman and Chief Executive Officer

<PAGE>

                        Integrated Surgical Systems, Inc.
                          1433 N. Market Blvd., Suite 1
                          Sacramento, California 95834

                SUPPLEMENT TO PROXY STATEMENT DATED MAY 25, 2007

Our Board of Directors has approved the payment of certain retention bonuses to
our employees to be paid contemporaneously with or subsequent to the date of
closing of the sale of substantially all of our assets to Novatrix Biomedical,
Inc. ("Novatrix").

The retention bonuses will be paid from the proceeds of the sale of our assets
to Novatrix. Ramesh C. Trivedi shall receive a retention bonus equal to five
percent of the cash received at closing and our remaining officers and key
employees shall receive proportional retention bonuses equal to an aggregate of
up to seven percent of the cash received at closing.

                  The Date of this Supplement is June 11, 2007.
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