<DOCUMENT>
<TYPE>EX-31.1
<SEQUENCE>3
<FILENAME>iss123107exh311.txt
<DESCRIPTION>CERTIFICATION
<TEXT>


Exhibit 31.1


                            CERTIFICATION PURSUANT TO
                  SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Peter B. Mills, Chief Executive Officer of Integrated Surgical Systems, Inc.,
certify that:

1.   I have reviewed this Annual Report on Form 10-KSB for the year ended
     December 31, 2007 of Integrated Surgical Systems, Inc.;

2.   Based on my knowledge, this report does not contain any untrue statement of
     a material fact or omit to state a material fact necessary to make the
     statements made, in light of the circumstances under which such statements
     were made, not misleading with respect to the period covered by this Annual
     Report;

3.   Based on my knowledge, the financial statements, and other financial
     information included in this report, fairly present in all material
     respects the financial condition, results of operations and cash flows of
     the small business issuer as of, and for, the periods presented in this
     Annual Report;

4. The small business issuer's other certifying officers and I are responsible
for establishing and maintaining disclosure controls and procedures (as defined
in Exchange Act Rules 13a-15(e) and 15d-15(e) and internal control over
financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f))
for the small business issuer and have:


          a) designed such disclosure controls and procedures, or caused such
          disclosure controls and procedures to be designed under our
          supervision, to ensure that material information relating to the small
          business issuer, including its consolidated subsidiaries, is made
          known to me by others within those entities, particularly during the
          period in which this Annual Report is being prepared;

          b) evaluated the effectiveness of the small business issuer's
          disclosure controls and procedures and presented in this Annual Report
          my conclusions about the effectiveness of the disclosure controls and
          procedures, as of the end of the period covered by this Annual Report
          based on such evaluation; and

          c) disclosed in this Annual Report any change in the small business
          issuer's internal control over financial reporting that occurred
          during the small business issuer's most recent fiscal quarter (the
          small business issuer's fourth fiscal quarter in the case of an annual
          report) that has materially affected, or is reasonably likely to
          materially affect, the small business issuer's internal control over
          financial reporting; and

5.   The small business issuer's other certifying officer(s) and I have
     disclosed, based on our most recent evaluation of internal control over
     financial reporting, to the small business issuer's auditors and the audit
     committee of the small business issuer's board of directors (or persons
     performing the equivalent functions);

          a) all significant deficiencies and material weaknesses in the design
          or operation of internal control over financial reporting which are
          reasonably likely to adversely affect the small business issuer's
          ability to record, process, summarize and report financial
          information; and

          b) any fraud, whether or not material, that involves management or
          other employees who have a significant role in the small business
          issuer's internal control over financial reporting.




Date: April 2, 2008                         By:   /s/ PETER B. MILLS
                                                  ------------------------------
                                                      Peter B. Mills
                                                      Chief Executive Officer

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</DOCUMENT>
