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Stock Based Compensation and Restricted Stock Compensation (Tables)
 9 Months Ended
Sep. 30, 2016
Stock Options [Member]  
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]  
Summarization of stock-based compensation
The following table summarizes stock-based compensation for the three and nine months ended September 30, 2016 and 2015:

  
Three months ended
September 30,
  
Nine months ended
September 30,
 
  
2016
  
2015
  
2016
  
2015
 
Research and development
 
$
274,000
  
$
142,000
  
$
937,000
  
$
246,000
 
General and administrative
  
643,000
   
1,310,000
   
2,957,000
   
2,335,000
 
Stock-based compensation expense included in operating expense
 
$
917,000
  
$
1,452,000
  
$
3,894,000
  
$
2,581,000
 
Restricted Stock [Member]  
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]  
Summarization of stock-based compensation
The following table summarizes restricted stock compensation expense for the three and nine months ended September 30, 2016 and 2015:

  
Three months ended
September 30,
  
Nine months ended
September 30,
 
  
2016
  
2015
  
2016
  
2015
 
Research and development
 
$
-
  
$
138,000
  
$
200,000
  
$
228,000
 
General and administrative
  
241,000
   
1,754,000
   
2,920,000
   
2,732,000
 
Restricted stock compensation expense included in operating expense
 
$
241,000
  
$
1,892,000
  
$
3,120,000
  
$
2,960,000