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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015
Cash flows from operating activities: |  |
Net loss | $ (21,873,000) | $ (14,526,000)
Adjustments to reconcile net loss to cash used in operating activities: |  |
Depreciation and amortization | 825,000 | 551,000
Stock option compensation expense | 4,829,000 | 4,368,000
Stock issued to directors, employees and consultants | 3,432,000 | 4,852,000
Stock issued for services | 0 | 401,000
Change in operating assets and liabilities: |  |
Receivables | (9,000) | (79,000)
Prepaid expenses and other current assets | 160,000 | (287,000)
Other assets | (4,000) | (29,000)
Accounts payable and accrued expenses | 2,819,000 | (1,174,000)
Contingent consideration milestone | (2,591,000) | (3,898,000)
Deferred revenue | (602,000) | (602,000)
Net cash used in operating activities | (13,014,000) | (10,423,000)
Cash flows from investing activities: |  |
Capital expenditures | (519,000) | (308,000)
Cash from Abeona Ohio acquisition | 0 | 3,697,000
Net cash provided by (used in) investing activities | (519,000) | 3,389,000
Cash flows from financing activities: |  |
Proceeds from $2.85 restricted common stock issuance | 150,000 | 0
Proceeds from exercise of stock options | 350,000 | 0
Proceeds from exercise of $5.00 warrants | 0 | 4,635,000
Payment of short-term debt | 0 | (400,000)
Net cash provided by financing activities | 42,537,000 | 35,652,000
Net increase in cash and cash equivalents | 29,004,000 | 28,618,000
Cash and cash equivalents at beginning of year | 40,138,000 | 11,520,000
Cash and cash equivalents at end of year | 69,142,000 | 40,138,000
Supplemental cash flow information: |  |
Cash paid for interest | 6,000 | 7,000
Supplemental disclosure of noncash transactions: |  |
Shares issued to holders of Abeona Ohio for acquisition | 0 | 31,758,000
Contingent milestones to Abeona Ohio members | 0 | 6,489,000
Licensed technology from Abeona Ohio | 0 | 2,156,000
Shares issued to EB Research Partnership and Epidermolysis Bullosa Medical Research Foundation for licenses | 2,452,000 | 0
$7.00 Common Stock Issuance [Member] |  |
Cash flows from financing activities: |  |
Proceeds from common stock issuances net of costs | 41,068,000 | 0
$6.44 Common Stock Issuance [Member] |  |
Cash flows from financing activities: |  |
Proceeds from common stock issuances net of costs | 969,000 | 0
$3.00 Common Stock Issuance [Member] |  |
Cash flows from financing activities: |  |
Proceeds from common stock issuances net of costs | 0 | 7,001,000
$8.00 Common Stock Issuance [Member] |  |
Cash flows from financing activities: |  |
Proceeds from common stock issuances net of costs | 0 | 9,005,000
$5.50 Common Stock Issuance [Member] |  |
Cash flows from financing activities: |  |
Proceeds from common stock issuances net of costs | $ 0 | $ 15,411,000

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