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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016
Cash flows from operating activities: |  |
Net loss | $ (27,319,000) | $ (21,873,000)
Adjustments to reconcile net loss to cash used in operating activities: |  |
Depreciation and amortization | 741,000 | 825,000
Stock option compensation expense | 4,644,000 | 4,829,000
Restricted common stock issued to directors and employees | 1,272,000 | 3,432,000
Net gain on write off of licensed technology | (127,000) | 0
Change in operating assets and liabilities: |  |
Receivables | 17,000 | (9,000)
Prepaid expenses and other current assets | (2,580,000) | 160,000
Other assets and restricted cash | (291,000) | (4,000)
Accounts payable and accrued expenses | (1,301,000) | 2,819,000
Contingent consideration milestone | 0 | (2,591,000)
Deferred revenue | 2,009,000 | (602,000)
Net cash used in operating activities | (22,935,000) | (13,014,000)
Cash flows from investing activities: |  |
Capital expenditures | (860,000) | (519,000)
Net cash used in by investing activities | (860,000) | (519,000)
Cash flows from financing activities: |  |
Proceeds from exercise of stock options | 344,000 | 350,000
Proceeds from $2.85 restricted common stock issuance | 0 | 150,000
Net cash provided by financing activities | 92,403,000 | 42,537,000
Net increase in cash and cash equivalents | 68,608,000 | 29,004,000
Cash and cash equivalents at beginning of year | 69,142,000 | 40,138,000
Cash and cash equivalents at end of year | 137,750,000 | 69,142,000
Supplemental cash flow information: |  |
Cash paid for interest | 8,000 | 6,000
Supplemental disclosure of noncash transactions |  |
Write off of licensed asset and corresponding liability | 4,000,000 | 0
Shares issued to EB Research Partnership and Epidermolysis | 0 | 0
Bullosa Medical Research Foundation for licenses | 0 | 2,452,000
Private Placement One [Member] |  |
Cash flows from financing activities: |  |
Proceeds From Issuance Of Common Stock | 86,174,000 | 0
Private Placement Two [Member] |  |
Cash flows from financing activities: |  |
Proceeds From Issuance Of Common Stock | 0 | 41,068,000
Private Placement Three [Member] |  |
Cash flows from financing activities: |  |
Proceeds From Issuance Of Common Stock | 0 | 969,000
Dollar Eight Warrant [Member] |  |
Cash flows from financing activities: |  |
Proceeds from Warrant Exercises | 5,000,000 | 0
Dollar Five Warrant [Member] |  |
Cash flows from financing activities: |  |
Proceeds from Warrant Exercises | $ 885,000 | $ 0

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