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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) | Total | Warrants Exercise One [Member] | Warrants Exercise Two [Member] | Common Stock Issuance One [Member] | Common Stock Issuance Two [Member] | Employees and Directors [Member] | Common Stock [Member] | Common Stock [Member] Warrants Exercise One [Member] | Common Stock [Member] Warrants Exercise Two [Member] | Common Stock [Member] Common Stock Issuance One [Member] | Common Stock [Member] Common Stock Issuance Two [Member] | Common Stock [Member] Employees and Directors [Member] | Additional Paid-in Capital [Member] | Additional Paid-in Capital [Member] Warrants Exercise One [Member] | Additional Paid-in Capital [Member] Warrants Exercise Two [Member] | Additional Paid-in Capital [Member] Common Stock Issuance One [Member] | Additional Paid-in Capital [Member] Common Stock Issuance Two [Member] | Additional Paid-in Capital [Member] Employees and Directors [Member] | Accumulated deficit [Member] | Accumulated deficit [Member] Warrants Exercise One [Member] | Accumulated deficit [Member] Warrants Exercise Two [Member] | Accumulated deficit [Member] Common Stock Issuance One [Member] | Accumulated deficit [Member] Common Stock Issuance Two [Member] | Accumulated deficit [Member] Employees and Directors [Member]
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2015 | $ 67,721,000 |  |  |  |  |  | $ 328,000 |  |  |  |  |  | $ 377,993,000 |  |  |  |  |  | $ (310,600,000) |  |  |  |  |
Balance (in shares) at Dec. 31, 2015 |  |  |  |  |  |  | 32,743,013 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted common stock issued | 150,000 |  |  |  |  | $ 3,432,000 | $ 0 |  |  |  |  | $ 1,000 | 150,000 |  |  |  |  | $ 3,431,000 | 0 |  |  |  |  | $ 0
Restricted common stock issued (in shares) |  |  |  |  |  |  | 52,690 |  |  |  |  | 100,000 |  |  |  |  |  |  |  |  |  |  |  |
Exercise of $5.00 warrants |  | $ 0 |  |  |  |  |  | $ 0 |  |  |  |  |  | $ 0 |  |  |  |  |  | $ 0 |  |  |  |
Exercise of $5.00 warrants (in shares) |  |  |  |  |  |  |  | 5,836 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued for services | 2,452,000 |  |  |  |  |  | $ 8,000 |  |  |  |  |  | 2,444,000 |  |  |  |  |  | 0 |  |  |  |  |
Common stock issued for services (in shares) |  |  |  |  |  |  | 750,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued for an average, net of costs |  |  |  | $ 969,000 | $ 41,068,000 |  |  |  |  | $ 2,000 | $ 63,000 |  |  |  |  | $ 967,000 | $ 41,005,000 |  |  |  |  | $ 0 | $ 0 |
Common stock issued for an average, net of costs (in shares) |  |  |  |  |  |  |  |  |  | 158,029 | 6,293,889 |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued for cash exercise of options | 350,000 |  |  |  |  |  | $ 1,000 |  |  |  |  |  | 349,000 |  |  |  |  |  | 0 |  |  |  |  |
Common stock issued for cash exercise of options (in shares) |  |  |  |  |  |  | 151,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock option compensation expense | 4,829,000 |  |  |  |  |  | $ 0 |  |  |  |  |  | 4,829,000 |  |  |  |  |  | 0 |  |  |  |  |
Net loss | (21,873,000) |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | (21,873,000) |  |  |  |  |
Balance at Dec. 31, 2016 | 99,098,000 |  |  |  |  |  | $ 403,000 |  |  |  |  |  | 431,168,000 |  |  |  |  |  | (332,473,000) |  |  |  |  |
Balance (in shares) at Dec. 31, 2016 |  |  |  |  |  |  | 40,254,457 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted common stock issued |  |  |  |  |  | $ 1,272,000 |  |  |  |  |  | $ 0 |  |  |  |  |  | $ 1,272,000 |  |  |  |  |  | $ 0
Restricted common stock issued (in shares) |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |
Exercise of $8.00 warrants |  | $ 5,000,000 |  |  |  |  |  | $ 6,000 |  |  |  |  |  | $ 4,994,000 |  |  |  |  |  | $ 0 |  |  |  |
Exercise of $8.00 warrants (in shares) |  |  |  |  |  |  |  | 625,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of $5.00 warrants |  |  | $ 885,000 |  |  |  |  |  | $ 2,000 |  |  |  |  |  | $ 883,000 |  |  |  |  |  | $ 0 |  |  |
Exercise of $5.00 warrants (in shares) |  |  |  |  |  |  |  |  | 176,932 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued for an average, net of costs |  |  |  | $ 86,174,000 |  |  |  |  |  | $ 58,000 |  |  |  |  |  | $ 86,116,000 |  |  |  |  |  | $ 0 |  |
Common stock issued for an average, net of costs (in shares) |  |  |  |  |  |  |  |  |  | 5,750,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued for cash exercise of options | 344,000 |  |  |  |  |  | $ 0 |  |  |  |  |  | 344,000 |  |  |  |  |  | 0 |  |  |  |  |
Common stock issued for cash exercise of options (in shares) |  |  |  |  |  |  | 81,719 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock option compensation expense | 4,644,000 |  |  |  |  |  | $ 0 |  |  |  |  |  | 4,644,000 |  |  |  |  |  | 0 |  |  |  |  |
Net loss | (27,319,000) |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | (27,319,000) |  |  |  |  |
Balance at Dec. 31, 2017 | $ 170,098,000 |  |  |  |  |  | $ 469,000 |  |  |  |  |  | $ 529,421,000 |  |  |  |  |  | $ (359,792,000) |  |  |  |  |
Balance (in shares) at Dec. 31, 2017 |  |  |  |  |  |  | 46,888,108 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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