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CONSOLIDATED STATEMENTS OF CASH FLOWS | 12 Months Ended
--- | ---
Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
Cash flows from operating activities: |  |  |
Net loss | $ (56,671,000) | $ (27,319,000) | $ (21,873,000)
Adjustments to reconcile net loss to cash used in operating activities: |  |  |
Depreciation and amortization | 2,360,000 | 741,000 | 825,000
Stock-based compensation expense | 8,178,000 | 4,644,000 | 4,829,000
Restricted stock-based compensation expense | 688,000 | 1,272,000 | 3,432,000
Non-cash earnings on investments | (626,000) | 0 | 0
Net gain on write-off of licensed technology | 0 | (127,000) | 0
Change in operating assets and liabilities: |  |  |
Receivables | 26,000 | 17,000 | (9,000)
Prepaid expenses and other current assets | (1,067,000) | (2,580,000) | 160,000
Other assets | 40,000 | (11,000) | (4,000)
Accounts payable and accrued expenses | 7,665,000 | (1,301,000) | 2,819,000
Contingent consideration milestone | 0 | 0 | (2,591,000)
Deferred revenue | 296,000 | 2,009,000 | (602,000)
Net cash used in operating activities | (39,111,000) | (22,655,000) | (13,014,000)
Cash flows from investing activities: |  |  |
Capital expenditures | (9,243,000) | (860,000) | (519,000)
Acquisition of licensed technology | (10,251,000) | 0 | 0
Purchases of short-term investments | (136,092,000) | 0 | 0
Proceeds from maturities of short-term investments | 70,500,000 | 0 | 0
Net cash used in investing activities | (85,086,000) | (860,000) | (519,000)
Cash flows from financing activities: |  |  |
Proceeds from exercise of stock options | 2,244,000 | 344,000 | 350,000
Proceeds from $2.85 restricted common stock issuance | 0 | 0 | 150,000
Net cash provided by financing activities | 5,477,000 | 92,403,000 | 42,537,000
Net (decrease)/increase in cash, cash equivalents and restricted cash | (118,720,000) | 68,888,000 | 29,004,000
Cash, cash equivalents and restricted cash at beginning of year | 138,030,000 | 69,142,000 | 40,138,000
Cash, cash equivalents and restricted cash at end of year | 19,310,000 | 138,030,000 | 69,142,000
Supplemental cash flow information: |  |  |
Cash and cash equivalents | 18,750,000 | 137,750,000 | 69,142,000
Restricted cash | 560,000 | 280,000 | 0
Total cash, cash equivalents and restricted cash | 19,310,000 | 138,030,000 | 69,142,000
Payable for acquistion of licensed technology | 30,000,000 | 0 | 0
Write off of licensed asset and corresponding liability | 0 | 4,000,000 | 0
Shares issued to EB Research Partnership and Epidermolysis Bullosa Medical Research Foundation for licenses | 0 | 0 | 2,452,000
Cash paid for interest | 11,000 | 8,000 | 6,000
Private Placement One [Member] |  |  |
Cash flows from financing activities: |  |  |
Proceeds From Issuance Of Common Stock | 0 | 86,174,000 | 0
Private Placement Two [Member] |  |  |
Cash flows from financing activities: |  |  |
Proceeds From Issuance Of Common Stock | 0 | 0 | 41,068,000
Private Placement Three [Member] |  |  |
Cash flows from financing activities: |  |  |
Proceeds From Issuance Of Common Stock | 0 | 0 | 969,000
Dollar Five Warrant [Member] |  |  |
Cash flows from financing activities: |  |  |
Proceeds from Warrant Exercises | 3,233,000 | 885,000 | 0
Dollar Eight Warrant [Member] |  |  |
Cash flows from financing activities: |  |  |
Proceeds from Warrant Exercises | $ 0 | $ 5,000,000 | $ 0

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- Definition Amount of cash outflow for purchase of marketable security. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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