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NATURE OF OPERATIONS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables) | 12 Months Ended
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Dec. 31, 2018
Antidilutive securities excluded from computation of earnings per share | We did not include the following potentially dilutive securities in the computation of diluted net loss per common share because the securities were anti-dilutive during the periods presented:
|  | For the years ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Warrants |  |  | 1,820,686 |  |  |  | 2,934,685 |  |  |  | 3,736,617 |
Stock options |  |  | 5,841,805 |  |  |  | 5,429,727 |  |  |  | 4,771,560 |
Total |  |  | 7,662,491 |  |  |  | 8,364,412 |  |  |  | 8,508,177 |
Employee Stock Option [Member] |
Stock-based compensation allocation | The following table summarizes stock-based option compensation for 2018, 2017 and 2016, which was allocated as follows:
|  | For the years ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Research and development |  | $ | 3,913,000 |  |  | $ | 1,668,000 |  |  | $ | 1,219,000 |
General and administrative |  |  | 4,265,000 |  |  |  | 2,976,000 |  |  |  | 3,610,000 |
Stock-based compensation expense included in operating expense |  |  | 8,178,000 |  |  |  | 4,644,000 |  |  |  | 4,829,000 |
Total stock-based compensation expense |  |  | 8,178,000 |  |  |  | 4,644,000 |  |  |  | 4,829,000 |
Tax benefit |  |  | — |  |  |  | — |  |  |  | — |
Stock-based compensation expense, net of tax |  | $ | 8,178,000 |  |  | $ | 4,644,000 |  |  | $ | 4,829,000 |
Restricted Stock [Member] |
Stock-based compensation allocation | The following table summarizes restricted stock-based compensation for 2018, 2017 and 2016, which was allocated as follows:
|  | For the years ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Research and development |  | $ | — |  |  | $ | — |  |  | $ | 200,000 |
General and administrative |  |  | 688,000 |  |  |  | 1,272,000 |  |  |  | 3,232,000 |
Stock-based compensation expense included in operating expense |  |  | 688,000 |  |  |  | 1,272,000 |  |  |  | 3,432,000 |
Total stock-based compensation expense |  |  | 688,000 |  |  |  | 1,272,000 |  |  |  | 3,432,000 |
Tax benefit |  |  | — |  |  |  | — |  |  |  | — |
Stock-based compensation expense, net of tax |  | $ | 688,000 |  |  | $ | 1,272,000 |  |  | $ | 3,432,000 |

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