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NATURE OF OPERATIONS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 1) - USD ($) | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Total stock based compensation expense | $ 8,178,000 | $ 4,644,000 | $ 4,829,000
Employee Stock Option [Member] |  |  |
Total stock based compensation expense | 8,178,000 | 4,644,000 | 4,829,000
Tax benefit | 0 | 0 | 0
Stock based compensation expense, net of tax | 8,178,000 | 4,644,000 | 4,829,000
Restricted Stock [Member] |  |  |
Total stock based compensation expense | 688,000 | 1,272,000 | 3,432,000
Tax benefit | 0 | 0 | 0
Stock based compensation expense, net of tax | 688,000 | 1,272,000 | 3,432,000
Research and development [Member] | Employee Stock Option [Member] |  |  |
Total stock based compensation expense | 3,913,000 | 1,668,000 | 1,219,000
Research and development [Member] | Restricted Stock [Member] |  |  |
Total stock based compensation expense | 0 | 0 | 200,000
General and administrative [Member] | Employee Stock Option [Member] |  |  |
Total stock based compensation expense | 4,265,000 | 2,976,000 | 3,610,000
General and administrative [Member] | Restricted Stock [Member] |  |  |
Total stock based compensation expense | 688,000 | 1,272,000 | 3,232,000
Operating Expense [Member] | Employee Stock Option [Member] |  |  |
Total stock based compensation expense | 8,178,000 | 4,644,000 | 4,829,000
Operating Expense [Member] | Restricted Stock [Member] |  |  |
Total stock based compensation expense | $ 688,000 | $ 1,272,000 | $ 3,432,000

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