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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) | Total | Warrants Exercise One [Member] | Warrants Exercise Two [Member] | Common Stock Issuance One [Member] | Common Stock Issuance Two [Member] | Common Stock [Member] | Common Stock [Member] Warrants Exercise One [Member] | Common Stock [Member] Warrants Exercise Two [Member] | Common Stock [Member] Common Stock Issuance One [Member] | Common Stock [Member] Common Stock Issuance Two [Member] | Additional Paid-in Capital [Member] | Additional Paid-in Capital [Member] Warrants Exercise One [Member] | Additional Paid-in Capital [Member] Warrants Exercise Two [Member] | Additional Paid-in Capital [Member] Common Stock Issuance One [Member] | Additional Paid-in Capital [Member] Common Stock Issuance Two [Member] | Accumulated deficit [Member] | Accumulated deficit [Member] Warrants Exercise One [Member] | Accumulated deficit [Member] Warrants Exercise Two [Member] | Accumulated deficit [Member] Common Stock Issuance One [Member] | Accumulated deficit [Member] Common Stock Issuance Two [Member]
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2015 | $ 67,721,000 |  |  |  |  | $ 328,000 |  |  |  |  | $ 377,993,000 |  |  |  |  | $ (310,600,000) |  |  |  |
Balance (in shares) at Dec. 31, 2015 |  |  |  |  |  | 32,743,013 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 4,829,000 |  |  |  |  | $ 0 |  |  |  |  | 4,829,000 |  |  |  |  | 0 |  |  |  |
Restricted stock-based compensation expense | 3,432,000 |  |  |  |  | $ 1,000 |  |  |  |  | 3,431,000 |  |  |  |  | 0 |  |  |  |
Restricted stock-based compensation expense (in shares) |  |  |  |  |  | 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted common stock issued | 150,000 |  |  |  |  | $ 0 |  |  |  |  | 150,000 |  |  |  |  | 0 |  |  |  |
Restricted common stock issued (in shares) |  |  |  |  |  | 52,690 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of $5.00 warrants | 0 |  |  |  |  | $ 0 |  |  |  |  | 0 |  |  |  |  | 0 |  |  |  |
Exercise of $5.00 warrants (in shares) |  |  |  |  |  | 5,836 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued for services | 2,452,000 |  |  |  |  | $ 8,000 |  |  |  |  | 2,444,000 |  |  |  |  | 0 |  |  |  |
Common stock issued for services (in shares) |  |  |  |  |  | 750,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued for an average, net of costs |  |  |  | $ 969,000 |  |  |  |  | $ 2,000 | $ 6,293,889 |  |  |  | $ 967,000 |  |  |  |  | $ 0 |
Common stock issued for an average, net of costs (in shares) |  |  |  |  | 41,068,000 |  |  |  | 158,029 | 63,000 |  |  |  |  | 41,005,000 |  |  |  |  | 0
Common stock issued for cash exercise of options | 350,000 |  |  |  |  | $ 1,000 |  |  |  |  | 349,000 |  |  |  |  | 0 |  |  |  |
Common stock issued for cash exercise of options (in shares) |  |  |  |  |  | 151,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (21,873,000) |  |  |  |  | $ 0 |  |  |  |  | 0 |  |  |  |  | (21,873,000) |  |  |  |
Balance (in shares) at Dec. 31, 2016 |  |  |  |  |  | 40,254,457 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Balance at Dec. 31, 2016 | 99,098,000 |  |  |  |  | $ 403,000 |  |  |  |  | 431,168,000 |  |  |  |  | (332,473,000) |  |  |  |
Stock-based compensation expense | 4,644,000 |  |  |  |  | 0 |  |  |  |  | 4,644,000 |  |  |  |  | 0 |  |  |  |
Restricted stock-based compensation expense | 1,272,000 |  |  |  |  | $ 0 |  |  |  |  | 1,272,000 |  |  |  |  | 0 |  |  |  |
Restricted stock-based compensation expense (in shares) |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of $8.00 warrants |  | $ 5,000,000 |  |  |  |  | $ 6,000 |  |  |  |  | $ 4,994,000 |  |  |  |  | $ 0 |  |  |
Exercise of $8.00 warrants (in shares) |  |  |  |  |  |  | 625,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of $5.00 warrants |  |  | $ 885,000 |  |  |  |  | $ 2,000 |  |  |  |  | $ 883,000 |  |  |  |  | $ 0 |  |
Exercise of $5.00 warrants (in shares) |  |  |  |  |  |  |  | 176,932 |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued for an average, net of costs |  |  |  | $ 86,174,000 |  |  |  |  | $ 58,000 |  |  |  |  | $ 86,116,000 |  |  |  |  | $ 0 |
Common stock issued for an average, net of costs (in shares) |  |  |  |  |  |  |  |  | 5,750,000 |  |  |  |  |  |  |  |  |  |  |
Common stock issued for cash exercise of options | 344,000 |  |  |  |  | $ 0 |  |  |  |  | 344,000 |  |  |  |  | 0 |  |  |  |
Common stock issued for cash exercise of options (in shares) |  |  |  |  |  | 81,719 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (27,319,000) |  |  |  |  | $ 0 |  |  |  |  | 0 |  |  |  |  | (27,319,000) |  |  |  |
Balance (in shares) at Dec. 31, 2017 |  |  |  |  |  | 46,888,108 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Balance at Dec. 31, 2017 | 170,098,000 |  |  |  |  | $ 469,000 |  |  |  |  | 529,421,000 |  |  |  |  | (359,792,000) |  |  |  |
Cumulative effect adjustment of ASC 606 on January 1, 2018 | 6,275,000 |  |  |  |  | 0 |  |  |  |  | 0 |  |  |  |  | 6,275,000 |  |  |  |
Stock-based compensation expense | 8,178,000 |  |  |  |  | 0 |  |  |  |  | 8,178,000 |  |  |  |  | 0 |  |  |  |
Restricted stock-based compensation expense | 688,000 |  |  |  |  | $ 0 |  |  |  |  | 688,000 |  |  |  |  | 0 |  |  |  |
Restricted stock-based compensation expense (in shares) |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of $5.00 warrants | 3,233,000 |  |  |  |  | $ 6,000 |  |  |  |  | 3,227,000 |  |  |  |  | 0 |  |  |  |
Exercise of $5.00 warrants (in shares) |  |  |  |  |  | 646,763 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued for cash exercise of options | 2,244,000 |  |  |  |  | $ 4,000 |  |  |  |  | 2,240,000 |  |  |  |  | 0 |  |  |  |
Common stock issued for cash exercise of options (in shares) |  |  |  |  |  | 360,853 |  |  |  |  |  |  |  |  |  |  |  |  |  |
cashless warrant exercises (in shares) |  |  |  |  |  | 48,762 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (56,671,000) |  |  |  |  | $ 0 |  |  |  |  | 0 |  |  |  |  | (56,671,000) |  |  |  |
cashless warrant exercises | 0 |  |  |  |  | $ 0 |  |  |  |  | 0 |  |  |  |  | 0 |  |  |  |
Balance (in shares) at Dec. 31, 2018 |  |  |  |  |  | 47,944,486 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Balance at Dec. 31, 2018 | $ 134,045,000 |  |  |  |  | $ 479,000 |  |  |  |  | $ 543,754,000 |  |  |  |  | $ (410,188,000) |  |  |  |

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- Definition Total of all stockholders' equity (deficit) items, net of receivables from officers, directors, owners, and affiliates of the entity which are attributable to the parent. The amount of the economic entity's stockholders' equity attributable to the parent excludes the amount of stockholders' equity which is allocable to that ownership interest in subsidiary equity which is not attributable to the parent (noncontrolling interest, minority interest). This excludes temporary equity and is sometimes called permanent equity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 310 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SAB Topic 4.E) -URI http://asc.fasb.org/extlink&oid=27010918&loc=d3e74512-122707 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(31)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(29)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(30)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
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Period Type: | instant