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QUARTERLY FINANCIAL DATA (UNAUDITED) (Tables) | 12 Months Ended
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Dec. 31, 2018
Quarterly Financial Information Disclosure [Abstract] |
Quarterly Financial Information [Table Text Block] | The operating results for any quarter are not necessarily indicative of results for any future period.
|  | Quarters Ended |
|  | December 31, 2018 |  |  | September 30, 2018 |  |  | June 30, 2018 |  |  | March 31, 2018 |
Foundation revenues (1)(2) |  | $ | 369,000 |  |  | $ | 1,687,000 |  |  | $ | 259,000 |  |  | $ | 481,000 |
License revenues (1) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Royalties (1) |  |  | 113,000 |  |  |  | 22,000 |  |  |  | 17,000 |  |  |  | 50,000 |
Research and development |  |  | 9,470,000 |  |  |  | 13,150,000 |  |  |  | 7,916,000 |  |  |  | 8,162,000 |
General and administrative |  |  | 7,631,000 |  |  |  | 4,970,000 |  |  |  | 4,627,000 |  |  |  | 2,878,000 |
Loss from operations (2) |  |  | (18,010,000 | ) |  |  | (16,916,000 | ) |  |  | (12,557,000 | ) |  |  | (10,683,000 | )
Net loss (2) |  |  | (17,479,000 | ) |  |  | (16,419,000 | ) |  |  | (12,243,000 | ) |  |  | (10,530,000 | )
Basic and diluted loss per common share |  |  | (0.36 | ) |  |  | (0.34 | ) |  |  | (0.26 | ) |  |  | (0.22 | )
Weighted average number of common shares outstanding – basic and diluted |  |  | 47,944,486 |  |  |  | 47,794,394 |  |  |  | 47,303,518 |  |  |  | 47,060,523 |
|  | Quarters Ended |
|  | December 31, 2017 |  |  | September 30, 2017 |  |  | June 30, 2017 |  |  | March 31, 2017 |
Foundation revenues (1) |  | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | — |
License revenues (1) |  |  | 150,000 |  |  |  | 151,000 |  |  |  | 150,000 |  |  |  | 151,000 |
Royalties (1) |  |  | 65,000 |  |  |  | 68,000 |  |  |  | 67,000 |  |  |  | 35,000 |
Research and development |  |  | 5,706,000 |  |  |  | 3,277,000 |  |  |  | 5,808,000 |  |  |  | 2,198,000 |
General and administrative |  |  | 3,113,000 |  |  |  | 2,166,000 |  |  |  | 2,642,000 |  |  |  | 3,022,000 |
Loss from operations |  |  | (8,750,000 | ) |  |  | (5,362,000 | ) |  |  | (8,440,000 | ) |  |  | (5,284,000 | )
Net loss |  |  | (8,450,000 | ) |  |  | (5,343,000 | ) |  |  | (8,279,000 | ) |  |  | (5,247,000 | )
Basic and diluted loss per common share |  |  | (0.19 | ) |  |  | (0.13 | ) |  |  | (0.21 | ) |  |  | (0.13 | )
Weighted average number of common shares outstanding – basic and diluted |  |  | 45,598,667 |  |  |  | 40,377,890 |  |  |  | 40,270,879 |  |  |  | 40,254,679 |
| (1) | Effective January 1, 2018, we adopted ASU 2014-09, Revenue from Contracts with Customers , as amended (ASC 606)), using the modified retrospective transition method. The ASC 606 revenue recognition standard replaced the prior revenue recognition standard ASC 605, Revenue Recognition . The statement of operations for each of the quarterly periods in 2018 are presented under ASC 606, while the statement of operations for each of the quarterly periods of 2017 are presented under ASC 605.
| (2) | We have adjusted the amounts originally reported for the quarters ended March 31, 2018 and June 30, 2018 to correct for an error in the determination of the cumulative effect related to the adoption of ASC 606 as of January 1, 2018. The adjusted amounts for March 31, 2018 reflect a $2,067,000 reduction in foundation revenues and corresponding increases in the loss from operations and net loss of $2,067,000 and an increase in the diluted loss per share of $0.04, as compared to the originally reported amounts. The adjusted amounts for June 30, 2018 reflect a $543,000 reduction in foundation revenues and corresponding increases in the loss from operations and net loss of $543,000 and an increase in the diluted loss per share of $0.01, as compared to the originally reported amounts.

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- Definition Tabular disclosure of quarterly financial data. Includes, but is not limited to, financial information for fiscal quarters, cumulative effect of a change in accounting principle and earnings per share data. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=109225645&loc=d3e1280-108306 + Details
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