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NATURE OF OPERATIONS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 1) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Total stock based compensation expense	$ 8,178,000	$ 4,644,000	$ 4,829,000
Employee Stock Option [Member]
Total stock based compensation expense	8,178,000	4,644,000	4,829,000
Tax benefit	0	0	0
Stock based compensation expense, net of tax	8,178,000	4,644,000	4,829,000
Restricted Stock [Member]
Total stock based compensation expense	688,000	1,272,000	3,432,000
Tax benefit	0	0	0
Stock based compensation expense, net of tax	688,000	1,272,000	3,432,000
Research and development [Member] | Employee Stock Option [Member]
Total stock based compensation expense	3,913,000	1,668,000	1,219,000
Research and development [Member] | Restricted Stock [Member]
Total stock based compensation expense	0	0	200,000
General and administrative [Member] | Employee Stock Option [Member]
Total stock based compensation expense	4,265,000	2,976,000	3,610,000
General and administrative [Member] | Restricted Stock [Member]
Total stock based compensation expense	688,000	1,272,000	3,232,000
Operating Expense [Member] | Employee Stock Option [Member]
Total stock based compensation expense	8,178,000	4,644,000	4,829,000
Operating Expense [Member] | Restricted Stock [Member]
Total stock based compensation expense	$ 688,000	$ 1,272,000	$ 3,432,000

X

- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901

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-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
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