<SEC-DOCUMENT>0000930413-19-002491.txt : 20190916
<SEC-HEADER>0000930413-19-002491.hdr.sgml : 20190916
<ACCEPTANCE-DATETIME>20190916161640
ACCESSION NUMBER:		0000930413-19-002491
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20190916
DATE AS OF CHANGE:		20190916

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ABEONA THERAPEUTICS INC.
		CENTRAL INDEX KEY:			0000318306
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				830221517
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-33655
		FILM NUMBER:		191094899

	BUSINESS ADDRESS:	
		STREET 1:		3333 LEE PARKWAY
		STREET 2:		SUITE 600
		CITY:			DALLAS
		STATE:			TX
		ZIP:			75219
		BUSINESS PHONE:		2149055100

	MAIL ADDRESS:	
		STREET 1:		3333 LEE PARKWAY
		STREET 2:		SUITE 600
		CITY:			DALLAS
		STATE:			TX
		ZIP:			75219

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PLASMATECH BIOPHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20140922

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ACCESS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19960209

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHEMEX PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19920703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GREAT POINT PARTNERS LLC
		CENTRAL INDEX KEY:			0001281446
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203 971-3300

	MAIL ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>c94263_sch13g.htm
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
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        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES<BR>
        SECURITIES AND EXCHANGE COMMISSION<BR>
        Washington, D.C. 20549</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Schedule 13G</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Amendment No&nbsp;&nbsp;)*</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Under the Securities Exchange
Act of 1934</B><BR></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">Abeona Therapeutics Inc.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(Name of Issuer)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid; font: bold 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">Common Shares, $0.01 par value</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(Title of Class of Securities)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid">
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">00289Y107</P>

</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(CUSIP Number)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid; font: bold 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">September 6, 2019</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(Date of Event which Requires Filing of this Statement)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 10pt">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; width: 18pt"><FONT STYLE="font-family: Wingdings">x</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; width: 18pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Rule 13d-1(b)</TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Rule 13d-1(c)</TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Rule 13d-1(d)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">*The remainder of this
cover page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover
page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The information required in the remainder
of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of
1934 (&ldquo;Act&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><B>Persons who respond to the collection of
information contained in this form are not required to respond unless the form displays a currently valid OMB control number.</B></P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
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    <TD STYLE="width: 28%; border: Black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No.</FONT>&nbsp;&nbsp;<B>00289Y107</B></TD>
    <TD STYLE="width: 49%; border-right: Black 1px solid; font: 16pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><B>13G</B></TD>
    <TD STYLE="width: 23%; border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt">Page
    2 of 9 Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding-top: 0; padding-right: 0; padding-bottom: 0; text-align: center; vertical-align: top; width: 36pt">
    <B>1.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><P STYLE="margin: 0"><B>NAMES OF REPORTING PERSONS</B></P>
                    <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
        <P STYLE="margin: 0">Great Point Partners, LLC</P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0">37-1475292</P></TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding-top: 0; padding-right: 0; padding-bottom: 0; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>2.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 0; text-indent: 0"><P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                                                <P STYLE="margin-top: 0; margin-bottom: 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></P></TD>
    </TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>3.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><B>SEC USE ONLY</B></TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>4.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><P STYLE="margin: 0"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></P>
                                                       <P STYLE="margin: 0"><B>&nbsp;</B></P>
        <P STYLE="margin: 0; text-indent: 0">USA</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="padding: 0; text-align: center; text-indent: 0; width: 20%"><P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0"><B>NUMBER OF SHARES</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0"><B>BENEFICIALLY</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>OWNED BY EACH</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>REPORTING PERSON</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>WITH</B></P></TD>
    <TD STYLE="text-align: center; padding: 0 0 0 5pt; width: 36pt"><B>5.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SOLE VOTING POWER</B></P>
                                                                                              <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding: 0 0 0 5pt"><B>6.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SHARED VOTING POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">2,833,656</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding: 0 0 0 5pt"><B>7.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SOLE DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding: 0 0 0 5pt"><B>8.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">2,833,656</P></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>9.</B></TD>
    <TD COLSPAN="2" STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
                                         REPORTING PERSON</B></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 36pt">2,833,656</P>

</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 10pt; padding-right: 0; padding-bottom: 0; width: 36pt"><B>10.</B></TD>
    <TD STYLE="padding: 10pt 0 0; vertical-align: top; text-indent: 0"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
    SHARES</B> (See Instructions)</TD>
    <TD STYLE="text-align: left; padding: 10pt 0 0; text-indent: 0; vertical-align: bottom; width: 5%"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>11.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">5.7%<SUP>1</SUP></P></TD>
    <TD STYLE="padding-top: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>12.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">IA</P></TD>
    <TD STYLE="padding-top: 10pt">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; width: 18pt; font: bold 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0pt; padding-top: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-weight: normal"><SUP>1</SUP></FONT></TD>
    <TD STYLE="vertical-align: bottom; font: bold 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 0pt; padding-top: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-weight: normal"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-weight: normal">Based on a total
of 49,315,751 shares outstanding, as reported by the Issuer in its quarterly report on Form 10-Q on August 9, 2019.</FONT></FONT></TD></TR>
</TABLE>



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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 28%; border: Black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No.</FONT>&nbsp;&nbsp;<B>00289Y107</B></TD>
    <TD STYLE="width: 49%; border-right: Black 1px solid; font: 16pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><B>13G</B></TD>
    <TD STYLE="width: 23%; border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt">Page
    3 of 9 Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding-top: 0; padding-right: 0; padding-bottom: 0; text-align: center; vertical-align: top; width: 36pt">
    <B>1.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><P STYLE="margin: 0"><B>NAMES OF REPORTING PERSONS</B></P>
                    <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
        <P STYLE="margin: 0">Dr. Jeffrey R. Jay, M.D.</P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P>

</TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding-top: 0; padding-right: 0; padding-bottom: 0; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>2.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 0; text-indent: 0"><P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                                                <P STYLE="margin-top: 0; margin-bottom: 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></P></TD>
    </TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>3.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><B>SEC USE ONLY</B></TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>4.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><P STYLE="margin: 0"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></P>
                                                       <P STYLE="margin: 0"><B>&nbsp;</B></P>
        <P STYLE="margin: 0; text-indent: 0">USA</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="padding: 0; text-align: center; text-indent: 0; width: 20%"><P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0"><B>NUMBER OF SHARES</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0"><B>BENEFICIALLY</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>OWNED BY EACH</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>REPORTING PERSON</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>WITH</B></P></TD>
    <TD STYLE="text-align: center; padding-top: 0; padding-right: 0; padding-bottom: 0; width: 36pt"><B>5.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SOLE VOTING POWER</B></P>
                                                                                              <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>6.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SHARED VOTING POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">2,833,656</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>7.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SOLE DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>8.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">2,833,656</P></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>9.</B></TD>
    <TD COLSPAN="2" STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
                                         REPORTING PERSON</B></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 36pt">2,833,656</P>

</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 10pt; padding-right: 0; padding-bottom: 0; width: 36pt"><B>10.</B></TD>
    <TD STYLE="padding: 10pt 0 0; vertical-align: top; text-indent: 0"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
    SHARES</B> (See Instructions)</TD>
    <TD STYLE="text-align: left; padding: 10pt 0 0; text-indent: 0; vertical-align: bottom; width: 5%"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>11.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">5.7%<SUP>1</SUP></P></TD>
    <TD STYLE="padding-top: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>12.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">IN</P></TD>
    <TD STYLE="padding-top: 10pt">&nbsp;</TD></TR>
</TABLE>


<!-- Field: Page; Sequence: 3 -->
    <DIV STYLE="margin-top: 0pt; margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 12pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; text-align: left"><TD STYLE="width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font-size: 10pt"><TR STYLE="vertical-align: top; text-align: left"><TD STYLE="width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->


<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 28%; border: Black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No.</FONT>&nbsp;&nbsp;<B>00289Y107</B></TD>
    <TD STYLE="width: 49%; border-right: Black 1px solid; font: 16pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><B>13G</B></TD>
    <TD STYLE="width: 23%; border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt">Page
    4 of 9 Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding-top: 0; padding-right: 0; padding-bottom: 0; text-align: center; vertical-align: top; width: 36pt">
    <B>1.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><P STYLE="margin: 0"><B>NAMES OF REPORTING PERSONS</B></P>
                    <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
        <P STYLE="margin: 0">Mr. David Kroin</P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P>

</TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding-top: 0; padding-right: 0; padding-bottom: 0; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>2.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 0; text-indent: 0"><P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                                                <P STYLE="margin-top: 0; margin-bottom: 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></P></TD>
    </TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>3.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><B>SEC USE ONLY</B></TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>4.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><P STYLE="margin: 0"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></P>
                                                       <P STYLE="margin: 0"><B>&nbsp;</B></P>
        <P STYLE="margin: 0; text-indent: 0">USA</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 0; padding-right: 0; padding-bottom: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="padding: 0; text-align: center; text-indent: 0; width: 20%"><P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0"><B>NUMBER OF SHARES</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0"><B>BENEFICIALLY</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>OWNED BY EACH</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>REPORTING PERSON</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>WITH</B></P></TD>
    <TD STYLE="text-align: center; padding-top: 0; padding-right: 0; padding-bottom: 0; width: 36pt"><B>5.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SOLE VOTING POWER</B></P>
                                                                                              <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>6.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SHARED VOTING POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">2,833,656</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>7.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SOLE DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 0; padding-right: 0; padding-bottom: 0"><B>8.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">2,833,656</P></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>9.</B></TD>
    <TD COLSPAN="2" STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
                                         REPORTING PERSON</B></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 36pt">2,833,656</P>

</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 10pt; padding-right: 0; padding-bottom: 0; width: 36pt"><B>10.</B></TD>
    <TD STYLE="padding: 10pt 0 0; vertical-align: top; text-indent: 0"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
    SHARES</B> (See Instructions)</TD>
    <TD STYLE="text-align: left; padding: 10pt 0 0; text-indent: 0; vertical-align: bottom; width: 5%"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>11.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">5.7%<SUP>1</SUP></P></TD>
    <TD STYLE="padding-top: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top; padding-top: 10pt; padding-right: 0; padding-bottom: 0"><B>12.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">IN</P></TD>
    <TD STYLE="padding-top: 10pt">&nbsp;</TD></TR>
</TABLE>


<!-- Field: Page; Sequence: 4 -->
    <DIV STYLE="margin-top: 0pt; margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 12pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; text-align: left"><TD STYLE="width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font-size: 10pt"><TR STYLE="vertical-align: top; text-align: left"><TD STYLE="width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 28%; border: Black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No.</FONT>&nbsp;&nbsp;<B>00289Y107</B></TD>
    <TD STYLE="width: 49%; border-right: Black 1px solid; font: 16pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><B>13G</B></TD>
    <TD STYLE="width: 23%; border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt">Page
    5 of 9 Pages</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="font: 10pt Arial, Helvetica, Sans-Serif; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Item 1.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of Issuer</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Abeona Therapeutics Inc.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Address of Issuer&rsquo;s Principal Executive Offices</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1330 Avenue of the Americas, New York, NY 10019</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif; text-align: center; width: 72pt"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Item 2.</B></FONT></TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif; width: 28pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">Name of Person Filing</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD></TR>
<TR>
    <TD ROWSPAN="7" STYLE="vertical-align: top; font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD>
    <TD COLSPAN="2">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt">Great Point Partners, LLC<BR>
        Dr. Jeffrey R. Jay, M.D.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt">Mr. David Kroin</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Reporting Persons have entered into
        a Joint Filing Agreement, dated September 16, 2019, a copy of which is filed with this Schedule 13G as Exhibit A, pursuant to which
        the Reporting Persons have agreed to file this statement jointly in accordance with the provisions of Rule 13d-1(k)(1) under the
        Act.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">Address of Principal Business Office, or if none, Residence</FONT></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The address of the principal business office of each of the
        Reporting Persons is</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 36pt">165 Mason Street, 3rd Floor</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 36pt">Greenwich, CT 06830</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">(c)</FONT></TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">Citizenship</FONT></TD></TR>
<TR>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="font: 10pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">Great Point Partners, LLC is a limited liability company organized under the laws of the State of Delaware.&nbsp;&nbsp;Dr. Jeffrey R. Jay, M.D. is a citizen of the United States. Mr. David Kroin is a citizen of the United States.</FONT><BR>
&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: left; vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(d)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Title of Class of Securities</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Common Shares, $0.01 par value</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(e)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">CUSIP Number</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">00289Y107</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Item 3.</B></FONT></TD>
    <TD COLSPAN="2">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>If this statement is filed pursuant to &sect;240.13d-1(b)
        or 240.13d.2(b) or (c), check whether the person filing is a:</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">Not Applicable.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</TD></TR>
</TABLE>


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<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="margin: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 72pt">&nbsp;</TD>
    <TD STYLE="width: 18pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD STYLE="width: 18pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o) </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Insurance company as defined in Section 3(a)(19) of the Act (15. U.S.C. 78c).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(d)</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Investment Company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(e)</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings">x</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">An investment adviser in accordance with &sect;240.13d-1(b)(1)(ii)(E).</FONT></TD></TR>
</TABLE>

<P STYLE="margin: 0"></P>

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    <TD STYLE="width: 28%; border: Black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No.</FONT>&nbsp;&nbsp;<B>00289Y107</B></TD>
    <TD STYLE="width: 49%; border-right: Black 1px solid; font: 16pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><B>13G</B></TD>
    <TD STYLE="width: 23%; border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt">Page
    6 of 9 Pages</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 72pt">&nbsp;</TD>
    <TD STYLE="width: 18pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(f)</FONT></TD>
    <TD STYLE="width: 18pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>An employee benefit plan or endowment fund in accordance with &sect;240.13d-1(b)(1)(ii)(F).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(g)</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">A parent holding company or control person in accordance with &sect;240.13d-1(b)(1)(ii)(G).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(h)</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(i)</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(j)</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Group, in accordance with &sect;240.13d-1(b)(1)(ii)(J).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


<P STYLE="margin: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="5" STYLE="width: 72pt; font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt"><B>Item 4.</B></FONT></TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Ownership</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Biomedical Value Fund, L.P. (&ldquo;BVF&rdquo;)
        is the record owner of 946,441 shares (the &ldquo;BVF Shares&rdquo;). Great Point Partners, LLC (&ldquo;Great Point&rdquo;) is
        the investment manager of BVF, and by virtue of such status may be deemed to be the beneficial owner of the BVF Shares. Each of
        Dr. Jeffrey R. Jay, M.D. (&ldquo;Dr. Jay&rdquo;), as senior managing member of Great Point, and Mr. David Kroin (&ldquo;Mr. Kroin&rdquo;),
        as special managing member of Great Point, has voting and investment power with respect to the BVF Shares, and therefore may be
        deemed to be the beneficial owner of the BVF Shares.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Biomedical Offshore Value Fund, Ltd. (&ldquo;BOVF&rdquo;)
        is the record owner of 1,224,140 shares (the &ldquo;BOVF Shares&rdquo;). Great Point is the investment manager of BOVF, and by
        virtue of such status may be deemed to be the beneficial owner of the BOVF Shares. Each of Dr. Jay, as senior managing member of
        Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the BOVF
        Shares, and therefore may be deemed to be the beneficial owner of the BOVF Shares.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">GEF-SMA, L.P. (&ldquo;GEF-SMA&rdquo;) is the record owner of 663,075 shares (the &ldquo;GEF-SMA Shares&rdquo;).&nbsp;&nbsp;Great Point is the investment manager with respect to the GEF-SMA Shares, and by virtue of such status may be deemed to be the beneficial owner of the GEF-SMA Shares.&nbsp;&nbsp;Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the GEF-SMA Shares, and therefore may be deemed to be the beneficial owner of the GEF-SMA Shares.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; text-align: justify"><P STYLE="margin-top: 0; margin-bottom: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
                                                                              <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Notwithstanding the above, Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares, the BOVF Shares, and the GEF-SMA Shares, except to the extent of their respective pecuniary interests. </FONT></P>
                                                                              <P STYLE="margin-top: 0; margin-bottom: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item&nbsp;1.</FONT></TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="margin: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">1.</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Great Point Partners, LLC</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Amount beneficially owned:&nbsp;&nbsp;2,833,656</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Percent of class:&nbsp;&nbsp;5.7%<SUP>1 </SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Number of shares as to which the person has:</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 72pt">&nbsp;</TD>
    <TD STYLE="width: 36pt">&nbsp;</TD>
    <TD STYLE="width: 36pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(i)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole power to vote or to direct the vote:&nbsp;&nbsp;0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(ii)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared power to vote or to direct the vote:&nbsp;&nbsp;2,833,656</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(iii)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole power to dispose or to direct the disposition of:&nbsp;&nbsp;0</FONT></TD></TR>
</TABLE>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
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    <TD STYLE="width: 28%; border: Black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No.</FONT>&nbsp;&nbsp;<B>00289Y107</B></TD>
    <TD STYLE="width: 49%; border-right: Black 1px solid; font: 16pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><B>13G</B></TD>
    <TD STYLE="width: 23%; border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt">Page
    7 of 9 Pages</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 72pt">&nbsp;</TD>
    <TD STYLE="width: 36pt">&nbsp;</TD>
    <TD STYLE="width: 36pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(iv)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared power to dispose or to direct the disposition of:&nbsp;&nbsp;2,833,656</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">2.</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Dr. Jeffrey R. Jay, M.D.</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Amount beneficially owned:&nbsp;&nbsp;2,833,656</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Percent of class:&nbsp;&nbsp;5.7%<SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Number of shares as to which the person has:</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(i)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole power to vote or to direct the vote:&nbsp;&nbsp;0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(ii)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared power to vote or to direct the vote: 2,833,656</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(iii)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole power to dispose or to direct the disposition of:&nbsp;&nbsp;0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(iv)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared power to dispose or to direct the disposition of:&nbsp;&nbsp;2,833,656</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3.</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Mr. David Kroin</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Amount beneficially owned:&nbsp;&nbsp;2,833,656</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Percent of class:&nbsp;&nbsp;5.7%<SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Number of shares as to which the person has:</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(i)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole power to vote or to direct the vote:&nbsp;&nbsp;0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(ii)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared power to vote or to direct the vote:&nbsp;&nbsp;2,833,656</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(iii)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole power to dispose or to direct the disposition of:&nbsp;&nbsp;0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(iv)</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared power to dispose or to direct the disposition of:&nbsp;&nbsp;2,833,656</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


<P STYLE="margin: 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 72pt">Item 5.</TD><TD>Ownership of Five Percent or Less of a Class</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">If this statement is
being filed to report the fact that as of the date hereof each of the Reporting Persons has ceased to be the beneficial owner
of more than five percent of the class of securities, check the following <FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 72pt">Item 6.</TD><TD>Ownership of More than Five Percent on Behalf of Another Person:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">See Item 4.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 72pt">Item 7.</TD><TD>Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Not Applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 72pt">Item 8.</TD><TD>Identification and Classification of Members of the Group</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Not Applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 72pt">Item 9.</TD><TD>Notice of Dissolution of Group</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Not Applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font-size: 10pt"><TR STYLE="vertical-align: top; text-align: left"><TD STYLE="width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 28%; border: Black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No.</FONT>&nbsp;&nbsp;<B>00289Y107</B></TD>
    <TD STYLE="width: 49%; border-right: Black 1px solid; font: 16pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><B>13G</B></TD>
    <TD STYLE="width: 23%; border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt">Page
    8 of 9 Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 72pt">Item 10.</TD><TD>Certification</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">By signing below I certify
that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not
held in connection with or as participant in any transaction having that purpose or effect.</P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 28%; border: Black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No.</FONT>&nbsp;&nbsp;<B>00289Y107</B></TD>
    <TD STYLE="width: 49%; border-right: Black 1px solid; font: 16pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><B>13G</B></TD>
    <TD STYLE="width: 23%; border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt">Page
    9 of 9 Pages</TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>SIGNATURE</U></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">Date: September 16, 2019</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif">GREAT POINT PARTNERS, LLC</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 50%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 3%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 37%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">By:&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1px solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Dr. Jeffrey R. Jay, M.D.,</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;as senior managing member</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1px solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif">DR. JEFFREY R. JAY, M.D.</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1px solid">/s/ Mr. David Kroin</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif">MR. DAVID KROIN</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><FONT STYLE="font-weight: normal"><U>Exhibit
A</U></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">AGREEMENT REGARDING THE JOINT FILING
OF SCHEDULE 13G</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The undersigned hereby agree as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each
of them is individually eligible to use the Schedule 13G to which this Exhibit is attached, and such Schedule 13G is filed on behalf
of each of them; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each
of them is responsible for the timely filing of such Schedule 13G and any amendments thereto, and for the completeness and accuracy
of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of
the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information
is inaccurate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Date: September 16, 2019</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif">GREAT POINT PARTNERS, LLC</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 3%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 37%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">By:</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1px solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Dr. Jeffrey R. Jay, M.D.,</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;as senior managing member</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1px solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif">DR. JEFFREY R. JAY, M.D.</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1px solid">/s/ Mr. David Kroin</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif">MR. DAVID KROIN</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
</TABLE>

















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