<SEC-DOCUMENT>0000930413-19-003101.txt : 20191230
<SEC-HEADER>0000930413-19-003101.hdr.sgml : 20191230
<ACCEPTANCE-DATETIME>20191230130749
ACCESSION NUMBER:		0000930413-19-003101
CONFORMED SUBMISSION TYPE:	SC 13D
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20191230
DATE AS OF CHANGE:		20191230

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ABEONA THERAPEUTICS INC.
		CENTRAL INDEX KEY:			0000318306
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				830221517
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-33655
		FILM NUMBER:		191315982

	BUSINESS ADDRESS:	
		STREET 1:		1330 AVENUE OF THE AMERICAS, 33RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
		BUSINESS PHONE:		646-813-4701

	MAIL ADDRESS:	
		STREET 1:		1330 AVENUE OF THE AMERICAS, 33RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PLASMATECH BIOPHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20140922

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ACCESS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19960209

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHEMEX PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19920703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GREAT POINT PARTNERS LLC
		CENTRAL INDEX KEY:			0001281446
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D

	BUSINESS ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203 971-3300

	MAIL ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D
<SEQUENCE>1
<FILENAME>c94828_sc13d.htm
<TEXT>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 11pt Times New Roman, Times, Serif">
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    <TD STYLE="width: 100%; padding-top: 0; padding-right: 0; padding-left: 0; text-align: center; font: 11pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt"><B>UNITED STATES </B></FONT><BR>
<FONT STYLE="font-size: 11pt"><B>SECURITIES AND EXCHANGE COMMISSION</B></FONT><BR>
<FONT STYLE="font-size: 11pt"><B>Washington, D.C. 20549</B></FONT><BR>
<BR>
<FONT STYLE="font-size: 11pt"><B>Schedule 13D</B></FONT><BR>
<FONT STYLE="font-size: 11pt"><B>Under the Securities Exchange Act of 1934</B></FONT><BR>
<FONT STYLE="font-size: 11pt"><B>(Amendment No. _____________)*</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1px solid; font: bold 11pt Times New Roman, Times, Serif; padding-top: 10pt; text-align: center; padding-right: 0; padding-left: 0"><FONT STYLE="font-size: 11pt">Abeona Therapeutics Inc.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 11pt Times New Roman, Times, Serif; text-align: center; padding-top: 0; padding-right: 0; padding-left: 0"><FONT STYLE="font-size: 11pt">(Name of Issuer)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1px solid; font: bold 11pt Times New Roman, Times, Serif; padding-top: 10pt; text-align: center; padding-right: 0; padding-left: 0"><FONT STYLE="font-size: 11pt">Common Stock</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 11pt Times New Roman, Times, Serif; text-align: center; padding-top: 0; padding-right: 0; padding-left: 0"><FONT STYLE="font-size: 11pt">(Title of Class of Securities)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1px solid; font: bold 11pt Times New Roman, Times, Serif; padding-top: 10pt; text-align: center; padding-right: 0; padding-left: 0"><FONT STYLE="font-size: 11pt">00289Y107</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 11pt Times New Roman, Times, Serif; text-align: center; padding-top: 0; padding-right: 0; padding-left: 0"><FONT STYLE="font-size: 11pt">(CUSIP Number)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1px solid; font: 11pt Times New Roman, Times, Serif; text-align: center; padding-top: 10pt; padding-right: 0; padding-left: 0"><FONT STYLE="font-size: 11pt"><B>Ron
    Panzier</B></FONT><BR>
    <FONT STYLE="font-size: 11pt"><B>Great Point Partners, LLC </B></FONT><BR>
    <FONT STYLE="font-size: 11pt"><B>165 Mason Street, 3<SUP>rd</SUP> Floor</B></FONT><BR>
    <FONT STYLE="font-size: 11pt"><B>Greenwich, CT 06830</B></FONT><BR>
    <FONT STYLE="font-size: 11pt"><B>(203) 971-3300</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 11pt Times New Roman, Times, Serif; text-align: center; padding-top: 0; padding-right: 0; padding-left: 0"><FONT STYLE="font-size: 11pt">(Name, Address and Telephone Number of Person Authorized to</FONT><BR>
<FONT STYLE="font-size: 11pt">Receive Notices and Communications)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1px solid; font: bold 11pt Times New Roman, Times, Serif; padding-top: 10pt; text-align: center; padding-right: 0; padding-left: 0"><FONT STYLE="font-size: 11pt">December 19, 2019</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 11pt Times New Roman, Times, Serif; text-align: center; padding-top: 0; padding-right: 0; padding-left: 0"><FONT STYLE="font-size: 11pt">(Date of Event which Requires Filing of this Statement)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If the filing person has previously filed
a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because
of &sect;&sect;240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box.<FONT STYLE="font-family: Wingdings">o</FONT></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note</B>: Schedule filed in paper format
shall include a signed original and five copies of the schedule, including all exhibits. See &sect;240.13d-7 for other parties
to whom copies are to be sent.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">*The remainder of this
cover page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover
page.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">The information required
in the remainder of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities
Exchange Act of 1934 (&ldquo;<U>Act</U>&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be
subject to all other provisions of the Act (however, see the Notes).</P>




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    <TD COLSPAN="4" STYLE="padding: 6pt 6pt 0; border-top: Black 3px double; border-right: Black 3px double">Names
    of Reporting Persons</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0 6pt; border-right: Black 1px solid; border-left: Black 3px double; text-align: center; width: 7%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 5%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 10%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 7%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 71%; border-right: Black 3px double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0 6pt 10pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding: 0 6pt 10pt; border-right: Black 3px double; border-bottom: Black 1px solid">Great
    Point Partners, LLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">2</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double">Check
    the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: left; padding-left: 6pt">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-right: 6pt; padding-bottom: 3pt; text-align: left">&nbsp;</TD>
    <TD STYLE="padding: 3pt 6pt">&nbsp;</TD>
    <TD STYLE="padding: 3pt 6pt; border-right: Black 3px double">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: left; border-bottom: Black 1px solid; padding-left: 6pt">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="3" STYLE="padding-top: 3pt; padding-right: 6pt; padding-bottom: 3pt; border-right: Black 3px double; border-bottom: Black 1px solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">3</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">SEC
    Use Only</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">4</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Source
    of Funds (See Instructions) AF</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">5</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Check
    if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) <FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">6</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Citizenship
    or Place of Organization Delaware</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" ROWSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-left: Black 3px double; border-bottom: Black 1px solid; vertical-align: middle">Number
    of Shares<BR>
    Beneficially Owned by<BR>
    Each Reporting Person With</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">7</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Sole Voting
    Power -0-</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">8</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Shared Voting
    Power 8,459,960</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">9</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid; text-align: left; vertical-align: bottom">Sole Dispositive
    Power -0-</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">10</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Shared Dispositive
    Power 8,459,960</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">11</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Aggregate
    Amount Beneficially Owned by Each Reporting Person 8,459,960</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">12</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Check if the Aggregate Amount in Row (11)
    Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">13</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Percent of Class Represented by Amount in
    Row (11) 9.99%<SUP>2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">14</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double">Type
    of Reporting Person (See Instructions)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 0; padding-left: 0; border-right: Black 3px double"><P STYLE="margin-top: 0; margin-bottom: 0; margin-left: 36pt">IA,
                                                                                OO (Limited Liability Company)</P>
                                                                                <!-- Field: Rule-Page --><DIV STYLE="text-align: center; margin: 0pt 36pt 0pt 6pt"><DIV STYLE="font-size: 1pt; border-top: Black 1px solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page --></TD></TR>                                                                                                                                                                                                                                                                                                                                   <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 0; padding-right: 0; padding-left: 0; border-right: Black 3px double">&nbsp;<!-- Field: Rule-Page --><DIV STYLE="text-align: center; margin: 0pt 36pt 0pt 6pt"><DIV STYLE="font-size: 1pt; border-top: Black 1px solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page --></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 0; padding-right: 0; padding-left: 0; border-right: Black 3px double">&nbsp;<!-- Field: Rule-Page --><DIV STYLE="text-align: center; margin: 0pt 36pt 0pt 6pt"><DIV STYLE="font-size: 1pt; border-top: Black 1px solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page --></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; border-bottom: Black 3px double; border-left: Black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 0; padding-right: 0; padding-left: 0; border-right: Black 3px double; border-bottom: Black 3px double">&nbsp;<!-- Field: Rule-Page --><DIV STYLE="text-align: center; margin: 0pt 300pt 0pt 6pt"><DIV STYLE="font-size: 1pt; border-top: Black 1px solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page --></TD></TR>
</TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 8pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">                                                                                                                                          <TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="width: 36pt"><SUP>1</SUP></TD><TD STYLE="text-align: justify">In addition to an aggregate of 7,213,012 shares of common stock in the aggregate held outright,
the reporting persons hold in the aggregate warrants to purchase 9,017,055 shares of common stock; however, the provisions of such
warrants restrict the exercise of such warrants to the extent that, after giving effect to such exercise, the holder of the warrants
and its affiliates, together with any other person or entities with which such holder would constitute a group, would beneficially
own in excess of 9.99% of the number of shares of common stock outstanding immediately after giving effect to such exercise (the
&ldquo;Beneficial Ownership Cap&rdquo;). As a result, an aggregate of 1,246,948 shares underlying such warrants are beneficially
owned by the reporting persons.</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="width: 36pt"><SUP>2</SUP></TD><TD STYLE="text-align: justify">Based on a total of 83,437,340 shares outstanding, as reported by the Issuer in that certain Prospectus
Supplement, dated December 20, 2019, to Prospectus dated June 7, 2018, filed with the SEC on December 23, 2019.</TD></TR></TABLE>




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    <TD STYLE="padding-top: 6pt; border-top: Black 3px double; border-right: Black 1px solid; border-left: Black 3px double; padding-bottom: 0; text-align: center">1</TD>
    <TD COLSPAN="4" STYLE="padding: 6pt 6pt 0; border-top: Black 3px double; border-right: Black 3px double">Names
    of Reporting Persons.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; border-left: Black 3px double; padding-bottom: 0; text-align: center; width: 7%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 5%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 10%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 7%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 71%; border-right: Black 3px double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 0; padding-right: 6pt; border-right: Black 3px double; padding-left: 6pt; border-bottom: Black 1px solid">Dr.
    Jeffrey R. Jay, M.D.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">2</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double">Check
    the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: left; padding-left: 6pt">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-right: 6pt; padding-bottom: 3pt; text-align: left">&nbsp;</TD>
    <TD STYLE="padding: 3pt 6pt">&nbsp;</TD>
    <TD STYLE="padding: 3pt 6pt; border-right: Black 3px double">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: left; border-bottom: Black 1px solid; padding-left: 6pt">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="3" STYLE="padding-top: 3pt; padding-right: 6pt; padding-bottom: 3pt; border-right: Black 3px double; border-bottom: Black 1px solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">3</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">SEC
    Use Only</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">4</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Source
    of Funds (See Instructions) AF</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">5</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Check
    if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) <FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">6</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Citizenship
    or Place of Organization United States</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" ROWSPAN="4" NOWRAP STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-left: Black 3px double; border-bottom: Black 1px solid; vertical-align: middle">Number
    of Shares<BR>
    Beneficially Owned by<BR>
    Each Reporting Person With</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">7</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Sole Voting
    Power -0-</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">8</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Shared Voting
    Power 8,459,960</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">9</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid; text-align: left; vertical-align: bottom">Sole Dispositive
    Power -0-</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">10</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Shared Dispositive
    Power 8,459,960</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">11</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Aggregate
    Amount Beneficially Owned by Each Reporting Person 8,459,960</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">12</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Check if the Aggregate Amount in Row (11)
    Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">13</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Percent of Class Represented by Amount in
    Row (11) 9.99%<SUP>2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-left: Black 3px double; text-align: center">14</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double">Type
    of Reporting Person (See Instructions)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-left: Black 3px double; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 0; padding-left: 0; border-right: Black 3px double"><P STYLE="margin-top: 0; margin-bottom: 0; margin-left: 36pt">IN, HC</P>
                                                                                <!-- Field: Rule-Page --><DIV STYLE="text-align: center; margin: 0pt 36pt 0pt 6pt"><DIV STYLE="font-size: 1pt; border-top: Black 1px solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page --></TD></TR>                                                                                                                                                                                                                                                                                                                                   <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; border-left: Black 3px double; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 0; padding-right: 0; padding-left: 0; border-right: Black 3px double">&nbsp;<!-- Field: Rule-Page --><DIV STYLE="text-align: center; margin: 0pt 36pt 0pt 6pt"><DIV STYLE="font-size: 1pt; border-top: Black 1px solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page --></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; border-bottom: Black 3px double; border-left: Black 3px double; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 0; padding-right: 0; padding-left: 0; border-right: Black 3px double; border-bottom: Black 3px double">&nbsp;<!-- Field: Rule-Page --><DIV STYLE="text-align: center; margin: 0pt 36pt 0pt 6pt"><DIV STYLE="font-size: 1pt; border-top: Black 1px solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page --></TD></TR>
</TABLE>


<!-- Field: Page; Sequence: 3 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-top: Black 3px double; padding-bottom: 0; border-right: Black 1px solid; border-left: Black 3px double; text-align: center">1</TD>
    <TD COLSPAN="4" STYLE="padding: 6pt 6pt 0; border-top: Black 3px double; border-right: Black 3px double">Names
    of Reporting Persons</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; padding-bottom: 0; border-left: Black 3px double; text-align: center; width: 7%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 5%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 10%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 7%">&nbsp;</TD>
    <TD STYLE="padding: 0 6pt; width: 71%; border-right: Black 3px double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 0; padding-right: 6pt; border-right: Black 3px double; padding-left: 6pt; border-bottom: Black 1px solid">Mr. David Kroin</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">2</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double">Check
    the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: left; padding-left: 6pt">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-right: 6pt; padding-bottom: 3pt"></TD>
    <TD STYLE="padding: 3pt 6pt">&nbsp;</TD>
    <TD STYLE="padding: 3pt 6pt; border-right: Black 3px double">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: left; border-bottom: Black 1px solid; padding-left: 6pt">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="3" STYLE="padding-top: 3pt; padding-right: 6pt; padding-bottom: 3pt; border-right: Black 3px double; border-bottom: Black 1px solid"></TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">3</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">SEC
    Use Only</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">4</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Source
    of Funds (See Instructions) AF</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">5</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Check
    if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) <FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">6</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Citizenship
    or Place of Organization United States</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" ROWSPAN="4" NOWRAP STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-left: Black 3px double; border-bottom: Black 1px solid; vertical-align: middle">Number
    of Shares<BR>
    Beneficially Owned by<BR>
    Each Reporting Person With</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">7</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Sole Voting
    Power -0-</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">8</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Shared Voting
    Power 8,459,960</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">9</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid; text-align: left; vertical-align: bottom">Sole Dispositive
    Power -0-</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 1px solid">10</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Shared Dispositive
    Power 8,459,960</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">11</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Aggregate
    Amount Beneficially Owned by Each Reporting Person 8,459,960</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">12</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Check if the Aggregate Amount in Row (11)
    Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center">13</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double; border-bottom: Black 1px solid">Percent of Class Represented by Amount in
    Row (11) 9.99%<SUP>2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-left: Black 3px double; text-align: center">14</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-right: Black 3px double">Type
    of Reporting Person (See Instructions)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 6pt; border-right: Black 1px solid; border-left: Black 3px double; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 6pt; padding-right: 0; padding-left: 0; border-right: Black 3px double"><P STYLE="margin-top: 0; margin-bottom: 0; margin-left: 36pt">IN, HC</P>
                                                                                <!-- Field: Rule-Page --><DIV STYLE="text-align: center; margin: 0pt 36pt 0pt 6pt"><DIV STYLE="font-size: 1pt; border-top: Black 1px solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page --></TD></TR>                                                                                                                                                                                                                                                                                                                                   <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; border-left: Black 3px double; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 0; padding-right: 0; padding-left: 0; border-right: Black 3px double">&nbsp;<!-- Field: Rule-Page --><DIV STYLE="text-align: center; margin: 0pt 36pt 0pt 6pt"><DIV STYLE="font-size: 1pt; border-top: Black 1px solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page --></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 0; border-right: Black 1px solid; border-bottom: Black 3px double; border-left: Black 3px double; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-top: 0; padding-right: 0; padding-left: 0; border-right: Black 3px double; border-bottom: Black 3px double">&nbsp;<!-- Field: Rule-Page --><DIV STYLE="text-align: center; margin: 0pt 36pt 0pt 6pt"><DIV STYLE="font-size: 1pt; border-top: Black 1px solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page --></TD></TR>
</TABLE>
<!-- Field: Page; Sequence: 4 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 72pt; font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Item 1.</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Security and Issuer</FONT></TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">The class of equity securities
to which this Schedule 13D (this &ldquo;<U>Statement</U>&rdquo;) relates is the common stock, $0.01 par value per share (the &ldquo;<U>Common
Stock</U>&rdquo;), of Abeona Therapeutics Inc., a Delaware corporation (the &ldquo;<U>Company</U>&rdquo; or the &ldquo;<U>Issuer</U>&rdquo;).
The address of the principal executive office of the Issuer is 1330 Avenue of the Americas, 33<SUP>rd</SUP> Floor, New York, NY
10019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 72pt; font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Item 2.</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Identity and Background</FONT></TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">This Statement is being
filed jointly on behalf of the following persons (collectively, the &ldquo;<U>Reporting Persons</U>&rdquo;): (i) Great Point Partners,
LLC, a Delaware limited liability company (&ldquo;<U>Great Point</U>&rdquo;); (ii) Dr. Jeffrey R. Jay, an individual (&ldquo;<U>Dr.
Jay</U>&rdquo;), and (iii) Mr. David Kroin, an individual (&ldquo;<U>Mr. Kroin</U>&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">The business address of
each Reporting Person is 165 Mason Street, 3rd Floor, Greenwich, CT 06830.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">During the last five years,
none of the Reporting Persons nor any of the Clients (as defined below) has been convicted in any criminal proceeding (excluding
traffic violations or similar misdemeanors).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">During the last five years,
none of the Reporting Persons nor any of the Clients (as defined below) has been party to a civil proceeding of a judicial or administrative
body of competent jurisdiction as a result of which such person was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation
with respect to such laws.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">Each of Dr. Jay and Mr.
Kroin is a United States citizen.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 72pt; font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Item 3.</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Source and Amount of Funds or Other Consideration</FONT></TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">Biomedical Value Fund,
L.P. (&ldquo;<U>BVF</U>&rdquo;) used its own funds to purchase 2,409,146 shares of Common Stock (the &ldquo;<U>BVF Shares</U>&rdquo;)
and warrants to purchase an additional 3,011,696 shares of Common Stock (the &ldquo;<U>BVF Warrants</U>&rdquo;). Biomedical Offshore
Value Fund, Ltd. (&ldquo;<U>BOVF</U>&rdquo;) used its own funds to purchase 3,116,022 shares of Common Stock (the &ldquo;<U>BOVF
Shares</U>&rdquo;) and warrants to purchase an additional 3,895,368 shares of Common Stock (the &ldquo;<U>BOVF Warrants</U>&rdquo;).
GEF-SMA, L.P. (&ldquo;<U>GEF-SMA</U>&rdquo;) used its own funds to purchase 1,687,844 shares of Common Stock (the &ldquo;<U>GEF-SMA
Shares</U>&rdquo;) and warrants to purchase an additional 2,109,991 shares of Common Stock (the &ldquo;<U>GEF-SMA Warrants</U>&rdquo;
and together with the BOVF Warrants and the BFV Warrants, the &ldquo;<U>GPP Warrants</U>&rdquo;).<SUP>3</SUP></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">See Item 5 below for information
with respect to Great Point, Dr. Jay and Mr. Kroin.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 72pt; font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Item 4.</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Purpose of Transaction</FONT></TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">The purpose for which the
Common Stock was acquired by the Reporting Persons is for investment. As such, in the ordinary course of their business, the Reporting
Persons will continuously evaluate the financial condition, results of operations, business and prospects of the Issuer, the securities
markets in general and the market for the Common Stock in particular, conditions in the economy and the financial institutions
industry generally and other investment opportunities, all with a view to determining whether to hold, decrease or increase its
investment in the Common Stock, through open market, privately</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 36pt; font: 8pt Times New Roman, Times, Serif; text-align: justify"><FONT STYLE="font-size: 8pt"><SUP>3</SUP></FONT></TD>
    <TD STYLE="font: 8pt Times New Roman, Times, Serif; text-align: justify"><FONT STYLE="font-size: 8pt">As described above, the GPP Warrants are subject to the Beneficial Ownership Cap.</FONT></TD></TR>
</TABLE>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0pt">negotiated or any other transactions.
In the ordinary course of evaluating its investment, representatives of the Reporting Persons may from time to time seek to (or
be invited to) discuss the business and policies of the Issuer with the management of the Issuer. Except as set forth in Item 6,
the securities of the Issuer are held for passive investment purposes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 72pt; font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Item 5.</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Interest in Securities of the Issuer</FONT></TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">BVF is the record holder
of the BVF Shares. Such shares constitute 2.89% of the shares of Common Stock outstanding, computed in accordance with Rule 13d-3.
BVF shares voting and dispositive power over the BVF Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">BVF is the record holder
of the BVF Warrants. As a result of the Beneficial Ownership Cap, 416,481 shares underlying such warrants are exercisable, which
constitutes 0.49% of the shares of Common Stock outstanding, computed in accordance with Rule 13d-3.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">BOVF is the record holder
of the BVF Shares. Such shares constitute 3.73% of the shares of Common Stock outstanding, computed in accordance with Rule 13d-3.
BOVF shares voting and dispositive power over the BOVF Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">BOVF is the record holder
of the BOVF Warrants. As a result of the Beneficial Ownership Cap, 538,682 shares underlying such warrants are exercisable, which
constitutes 0.64% of the shares of Common Stock outstanding, computed in accordance with Rule 13d-3.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">GEF-SMA is the record holder
of the GEF-SMA Shares. Such shares constitute 2.02% of the shares of Common Stock outstanding, computed in accordance with Rule
13d-3. GEF-SMA shares voting and dispositive power over the GEF-SMA Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">GEF-SMA is the record holder
of the GEF-SMA Warrants. As a result of the Beneficial Ownership Cap, 291,786 shares underlying such warrants are exercisable,
which constitutes 0.34% of the shares of Common Stock outstanding, computed in accordance with Rule 13d-3.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">BVF, BOVF and GEF-SMA (BVF,
BOVF, and GEF-SMA, collectively, the &ldquo;<U>Clients</U>&rdquo;), and the Clients&rsquo; respective general partners have granted
full investment and voting authority and discretion to Great Point, as a result of which Great Point may be deemed to be the beneficial
owner of the BVF Shares, the BOVF Shares and the GEF-SMA Shares. Each of Dr. Jay, as senior managing member of Great Point, and
Mr. Kroin, and special managing member of Great Point, has shared voting and investment power with respect to the BVF Shares, the
BOVF Shares, and the GEF-SMA Shares and may be deemed to be the beneficial owner of such shares. Great Point, Dr. Jay and Mr. Kroin
disclaim beneficial ownership of the BVF Shares, the BOVF Shares and the GEF-SMA Shares except to the extent of any pecuniary interest,
and this statement shall not be deemed to be an admission that they are the beneficial owners of such securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 72pt; font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt; text-align: left; vertical-align: top"><FONT STYLE="font-size: 10pt">Item 6.</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer</FONT></TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">Pursuant to the letter
agreement attached hereto as Exhibit B (the &ldquo;<U>Letter Agreement</U>&rdquo;), the Issuer and the Reporting Persons have
agreed that (i) the Reporting Persons have the right to identify two candidates to be nominated and, subject to qualification,
elected to vacancies on the Issuer&rsquo;s board of directors, including the Executive Chairman of the Issuer&rsquo;s board of
directors (but the Reporting Persons</P>


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    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0pt">have no current expectation
that such nominees will be affiliates of the Reporting Persons), and (ii) until the election of an Executive Chairman so nominated
by the Reporting Persons, the Issuer will not, without the Reporting Persons&rsquo; prior written consent, enter into any material
transaction to commercialize or develop any of Issuer&rsquo;s material intellectual property or technology. Once the Issuer&rsquo;s
obligations under the Letter Agreement are fully performed, the Reporting Persons will have no further rights thereunder. The foregoing
description of the Letter Agreement does not purport to be complete and is qualified in their entirety by reference to the full
texts of the Letter Agreement, which is incorporated by reference as Exhibit B and is incorporated herein by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 72pt; font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt; text-align: left; vertical-align: top"><FONT STYLE="font-size: 10pt">Item 7.</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-indent: 0pt"><FONT STYLE="font-size: 10pt">Material to be Filed as Exhibits</FONT></TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt; text-indent: -72pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 72pt; text-align: justify; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="text-align: justify; text-indent: 0pt">The following documents are
    filed as exhibits and are incorporated herein.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: justify; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="text-align: justify; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>EXHIBIT A: Joint Filing Agreement, dated as of December 30, 2019.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>EXHIBIT B: Letter Agreement, dated as of December 20, 2019.</TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left"><FONT STYLE="font-weight: normal"><I>Signature</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left"><FONT STYLE="font-weight: normal"><I>&nbsp;</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Date: December 30, 2019</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left"><FONT STYLE="font-size: 10pt"><B>Great Point Partners, LLC</B></FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left; width: 55%">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-bottom: 1px; width: 1%"><FONT STYLE="font-size: 10pt">By: </FONT></TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid; width: 4%">&nbsp;</TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid; width: 35%"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="text-align: left; width: 5%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Name: Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Title: Senior Managing Member</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>

<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Dr. Jeffrey R. Jay, individually</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left"><FONT STYLE="font-size: 10pt">/s/ Mr. David Kroin</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Mr. David Kroin, individually</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right"><B>Exhibit A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE
13D</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left">The undersigned hereby agree as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 36pt"></TD><TD STYLE="width: 36pt"><FONT STYLE="font-size: 10pt">(i)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Each of them is individually eligible to use the Schedule 13D to
which this Exhibit is attached, and such Schedule 13D is filed on behalf of each of them; and</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 36pt"></TD><TD STYLE="width: 36pt"><FONT STYLE="font-size: 10pt">(ii)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Each of them is responsible for the timely filing of such Schedule
13D and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein;
but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing,
unless such person knows or has reason to believe that such information is inaccurate.</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Date:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;December 30, 2019</FONT></TD>
    <TD COLSPAN="3" STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left"><FONT STYLE="font-size: 10pt"><B>Great Point Partners, LLC</B></FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left; width: 55%">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-bottom: 1px; width: 1%"><FONT STYLE="font-size: 10pt">By: </FONT></TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid; width: 4%">&nbsp;</TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid; width: 35%"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="text-align: left; width: 5%"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Name: Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Title: Senior Managing Member</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>

<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Dr. Jeffrey R. Jay, individually</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left"><FONT STYLE="font-size: 10pt">/s/ Mr. David Kroin</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Mr. David Kroin, individually</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>
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<P STYLE="text-align: right; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>Exhibit B</B></P>

<P STYLE="text-align: right; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="text-align: center; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">Abeona Therapeutics Inc.<BR>
1330 Avenue of the Americas, 33rd Floor<BR>
New York, NY 10019</P>

<P STYLE="text-align: center; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="text-align: center; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">December 20, 2019</P>

<P STYLE="text-align: center; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">Biomedical Value Fund, L.P.</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">Biomedical Offshore Value Fund, Ltd.</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></P>

<P STYLE="margin: 0pt 0 0pt 20pt; font: 10pt Times New Roman, Times, Serif">and</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">GEF-SMA, L.P.</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">c/o Great Point Partners LLC</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">165 Mason Street, 3<SUP>rd</SUP> Floor</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">Greenwich, Connecticut 06830</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif"><B>&nbsp;</B></TD>
    <TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif"><B>Re:</B></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><B>Letter Agreement regarding Certain Purchaser Rights</B></TD></TR>
</TABLE>
<P STYLE="text-align: justify; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="text-align: justify; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">Ladies and Gentlemen:</P>

<P STYLE="text-align: justify; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="text-align: justify; text-indent: 36pt; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">Abeona Therapeutics Inc., a Delaware corporation (the &ldquo;Company&rdquo;),
is contemplating an offering of shares of common stock, par value $0.01 per share (&ldquo;Common Stock&rdquo;), and warrants to
purchase shares of Common Stock as described in the Company&rsquo;s Prospectus Supplement, dated December 20, 2019, to the Prospectus
dated June 7, 2018 (the &ldquo;Offering&rdquo;). In consideration for Biomedical Value Fund, L.P., Biomedical Offshore Value Fund,
Ltd. and GEF-SMA, L.P. (collectively, &ldquo;Purchaser&rdquo;) purchasing in the aggregate at least $31 million in Common Stock
and/or warrants in the Offering, the Company and Purchaser agree as follows:</P>

<P STYLE="text-align: justify; text-indent: 36pt; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="text-align: justify; text-indent: 36pt; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">1.</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><I>Corporate Governance Matters.</I></TD></TR>
</TABLE>

<P STYLE="text-align: justify; text-indent: 36pt; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 72pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(a)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif"><I>Identification and Nomination
                                                             of Chairman Candidate.</I></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 108pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(i)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif">By written notice to the Company no later than March 31, 2020 (the &ldquo;Nomination Deadline&rdquo;),
Purchaser shall have the right to identify a successor candidate for Chairman of the Board and Executive Chairman (the &ldquo;Chairman
Candidate&rdquo;) who (A) is reasonably experienced in the Company&rsquo;s industry, (B) is not affiliated with Purchaser and (C)
otherwise meets the criteria of the Company&rsquo;s Nominating and Corporate Governance Committee (the &ldquo;Nominating Committee&rdquo;)
for nominees and applicable rules and regulations of the Securities Exchange Act of 1934, as amended, and the Nasdaq Capital Market
(such qualifications set forth in clauses (A), (B) and (C) collectively, the &ldquo;Qualification Criteria&rdquo;).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 108pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(ii)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif">As soon as practicable following Purchaser&rsquo;s identification of a Chairman Candidate pursuant
to paragraph 1(a)(i), the Company shall use commercially reasonable efforts to cause its Compensation Committee to negotiate and
agree to a compensation package with the Chairman Candidate. In the event that the Compensation Committee and the Chairman Candidate
cannot reach agreement as to the Chairman Candidate&rsquo;s compensation package within fifteen (15) days, the compensation package
finally offered to the Chairman Candidate shall be as mutually agreed-upon by the Compensation Committee and Purchaser</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>


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<P STYLE="text-align: justify; text-indent: 0pt; margin: 0pt 0 0pt 144pt; font: 10pt Times New Roman, Times, Serif">to be reasonable and market standard for such position;
<U>provided</U>, <U>however</U>, that in any event the compensation paid by the Company to its previous Chairman of the Board
and Executive Chairman shall be deemed reasonable and market standard for such purposes.</P>

<P STYLE="text-align: justify; text-indent: 0pt; margin: 0pt 0 0pt 144pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 108pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(iii)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif">Upon agreement by the Chairman Candidate and the Compensation Committee to a compensation package,
the Company shall use its commercially reasonable efforts to promptly (A) cause the Nominating Committee to nominate the Chairman
Candidate as the successor Chairman of the Board and Executive Chairman, and (B) cause the Company&rsquo;s board of directors (the
&ldquo;Board&rdquo;) to so elect to the Board the Chairman Candidate to fill the vacancy created by the resignations described
in paragraphs 1(c)(i) and (ii).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 108pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(iv)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif">If (A) the Compensation Committee and the Chairman Candidate do not reach agreement on a compensation
package pursuant to paragraph 1(a)(ii), (B) the Nominating Committee rejects the Chairman Candidate pursuant to paragraph 1(a)(iii)(A)
or (C) the Board fails to elect the Chairman Candidate pursuant to paragraph 1(a)(iii)(B), then Purchaser shall be granted an additional
period of thirty (30) days to identify by written notice to the Company a new Chairman Candidate pursuant to paragraph 1(a)(i)
(except that such new candidate need not satisfy clause (B) of the definition of Qualification Criteria), and the covenants set
forth under this paragraph 1(a) shall again apply to such new Chairman Candidate.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 72pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(b)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><I>Identification and Nomination of Director Candidate.</I></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 108pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(i)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif">By written notice to the Company no later than the Nomination Deadline, Purchaser shall have the
right to identify an additional successor director who meets the Qualification Criteria (the &ldquo;Director Candidate&rdquo;).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 108pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(ii)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif">Upon Purchaser&rsquo;s identification of a Director Candidate pursuant to paragraph 1(b)(i), the
Company shall use its commercially reasonable efforts to promptly (A) cause the Nominating Committee to nominate the Director Candidate
to the Board and (B) cause the Board to so elect to the Board the Director Candidate to fill the vacancy created by the resignation
described in paragraph 1(c)(iii).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 108pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(iii)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif">If (A) the Nominating Committee rejects the Director Candidate pursuant to paragraph 1(b)(ii)(A)
or (ii) the Board fails to elect the Director Candidate pursuant to paragraph 1(b)(ii)(B), then Purchaser shall be granted an additional
period of thirty (30) days to identify by written notice to the Company a new Director Candidate pursuant to paragraph 1(b)(i)
(except that such new candidate need not satisfy clause (B) of the definition of Qualification Criteria), and the covenants set
forth under this paragraph 1(b) shall again apply to such new Director Candidate.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 72pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(c)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif"><I>Resignations.</I> Concurrently
                                                              with the execution of this letter agreement, the Company has delivered
                                                              to Purchaser the following, in each case reasonably acceptable to
                                                              Purchaser:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>


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<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 108pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(i)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif">from Steven H. Rouhandeh, a duly executed letter of resignation in his capacity as the Company&rsquo;s
Chairman of the Board and Executive Chairman (but, for the avoidance of doubt, not from the Board), effective at the time that
the Board is in a position to elect the Chairman Candidate pursuant to paragraph 1(a)(iii)(B), but in any event immediately prior
to such election;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 108pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(ii)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif">from Mark J. Alvino, a duly executed letter of resignation from the Company&rsquo;s board of directors,
effective as of the time that the Board is in a position to elect the Chairman Candidate pursuant to paragraph 1(a)(iii)(B), but
in any event immediately prior to such election; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 108pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(iii)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif">from Richard Van Duyne, a duly executed letter of resignation from the Company&rsquo;s board of
directors, effective as of the time that the Board is in a position to elect the Director Candidate pursuant to paragraph 1(b)(ii)(B),
but in any event immediately prior to such election.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 72pt; font: 10pt Times New Roman, Times, Serif"></TD><TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif">(d)</TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif"><I>Fees and Expenses.</I> The Company
                                                             shall pay on Purchaser&rsquo;s behalf or reimburse Purchaser for,
                                                             as applicable, all reasonable out-of-pocket fees, costs and expenses
                                                             incurred in connection with the search for and recruitment of the
                                                             candidates described in paragraphs 1(a) and (b), including, without
                                                             limitation, fees, costs and expenses of recruitment or search firms
                                                             engaged by Purchaser.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="text-align: justify; text-indent: 36pt; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">2.&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Purchaser
Consent Right.</I> From the date hereof until the election of the Chairman Candidate pursuant to paragraph 1(a)(iii)(B), the Company
shall not, without the prior written consent of Purchaser, enter into any material transaction with respect to the commercialization
or development of any material intellectual property or technology of the Company, or enter into any binding agreement, commitment
or obligation with respect to any such material transaction.</P>

<P STYLE="text-align: justify; text-indent: 36pt; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="text-align: justify; text-indent: 36pt; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">3.&#9;&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Miscellaneous.
</I>This letter agreement constitutes the entire agreement between the parties hereto pertaining to the subject matter hereof,
and supersedes all prior and contemporaneous agreements, understandings, negotiations and discussions of the parties, whether
written or oral, with respect to the subject matter hereof. Each party has been represented and advised by independent counsel
of its choice in connection with the execution of this letter agreement and has cooperated in the drafting and preparation of
this letter agreement. Accordingly, any law that would require interpretation of this letter agreement, including any ambiguous,
vague or conflicting term herein, against the drafter should not apply and is expressly waived. This letter agreement shall be
deemed to have been made and performed in, and shall be governed and construed in accordance with the laws of, the State of New
York, without regard to conflicts of law principles. Nothing in this letter agreement is intended to or shall confer upon any
third party any benefits, rights or remedies of any nature whatsoever under or by reason of this letter agreement. This letter
agreement may be executed in any number of counterparts and by the parties hereto in separate counterparts, each of which when
so executed will be deemed to be an original and all of which taken together shall constitute one and the same agreement. Facsimile
or electronic signatures hereto shall be deemed to have the same force and effect as original signatures.</P>

<P STYLE="text-align: justify; text-indent: 36pt; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="text-align: center; text-indent: 0pt; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">[<I>Remainder of page
intentionally left blank</I>]</P>

<P STYLE="text-align: center; text-indent: 0pt; margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></P>


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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="color: black">Very truly yours,</FONT></TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 50%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 4%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 7%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 39%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="color: black">ABEONA THERAPEUTICS INC.</FONT></TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid; font: 10pt Times New Roman, Times, Serif">/s/ Steven H. Rouhandeh</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Name:&nbsp;&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Steven H. Rouhandeh</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Title:</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Executive Chairman</TD></TR>
</TABLE>
<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">Agreed and acknowledged as of the date first set forth above by:</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">BIOMEDICAL VALUE FUND, L.P.</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">By:</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif">Great Point Partners, LLC, its investment manager</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid; font: 10pt Times New Roman, Times, Serif">/s/ David Kroin</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 4%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 7%; font: 10pt Times New Roman, Times, Serif">Name:&nbsp;&nbsp;</TD>
    <TD STYLE="width: 39%; font: 10pt Times New Roman, Times, Serif">David Kroin</TD>
    <TD STYLE="width: 50%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Title:</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Managing Director</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">BIOMEDICAL OFFSHORE VALUE FUND, LTD.</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">By:</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif">Great Point Partners, LLC, its investment manager</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 4%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 7%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 39%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 50%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid; font: 10pt Times New Roman, Times, Serif">/s/ David Kroin</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Name:&nbsp;&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">David Kroin</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Title:</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Managing Director</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">GEF-SMA, L.P.</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">By:</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif">Great Point Partners, LLC, its investment manager</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid; font: 10pt Times New Roman, Times, Serif">/s/ David Kroin</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 4%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 7%; font: 10pt Times New Roman, Times, Serif">Name:&nbsp;&nbsp;</TD>
    <TD STYLE="width: 39%; font: 10pt Times New Roman, Times, Serif">David Kroin</TD>
    <TD STYLE="width: 50%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Title:</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Managing Director</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
</TABLE>




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