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Stockholders' Equity (Details Narrative) - USD ($) |  |  | 12 Months Ended
--- | --- | --- | ---
Dec. 24, 2019 | Oct. 19, 2017 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Warrants to purchase |  |  | 70,000 |  |
Warrants exercise price |  |  | $ 5.00 | $ 5.00 | $ 5.00
Issuance of common shares, value |  |  |  |  | $ 86,174,000
Proceeds from Warrant Exercises |  |  |  | $ 3,233,000 | $ 885,000
Common Stock [Member] |  |  |  |  |
Issuance of common shares |  |  |  |  | 5,750,000
Issuance of common shares, value |  |  |  |  | $ 58,000
Non - Pre - Funded Warrants [Member] |  |  |  |  |
Warrants to purchase |  |  | 70,000 | 1,820,686 |
Proceeds from Warrant Exercises |  |  | $ 0 | $ 3,200,000 | $ 5,900,000
Non - Pre - Funded Warrants [Member] | Common Stock [Member] |  |  |  |  |
Warrants to purchase |  |  | 1,750,686 |  |
Warrant expiration, description |  |  | expired during 2019. |  |
2019 Public Offering [Member] |  |  |  |  |
Issuance of common shares | 32,382,945 |  |  |  |
Shares issued, price per share | $ 2.50 |  |  |  |
Issuance of common shares, value | $ 103,500,000 |  |  |  |
2019 Public Offering [Member] | Pre - Funded Warrants [Member] |  |  |  |  |
Warrants to purchase |  |  | 9,017,055 |  |
Warrants exercise price | $ 0.0001 |  |  |  |
2019 Public Offering [Member] | Maximum [Member] |  |  |  |  |
Warrants to purchase | 9,017,055 |  |  |  |
Warrants exercise price | $ 2.4999 |  |  |  |
2017 Public Offering [Member] |  |  |  |  |
Issuance of common shares |  | 5,750,000 |  |  |
Shares issued, price per share |  | $ 16.00 |  |  |
Issuance of common shares, value |  | $ 92,000,000 |  |  |

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