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v3.21.1

Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities: |  |
Net loss | $ (84,234,000) | $ (76,282,000)
Adjustments to reconcile net loss to cash used in operating activities: |  |
Non-cash licensed technology impairment charge | 32,916,000 |
Depreciation and amortization | 4,586,000 | 7,819,000
Stock option-based compensation expense | 5,853,000 | 7,338,000
Restricted stock-based compensation expense | 2,334,000 | 899,000
Non-cash interest expense | 600,000 |
Accretion and interest on short-term investments | (70,000) | (266,000)
Accretion of right-of-use lease assets | 1,015,000 | 858,000
Other | 347,000 | 367,000
Change in operating assets and liabilities: |  |
Receivables |  | 81,000
Prepaid expenses and other current assets | 424,000 | 670,000
Other assets | (127,000) | 3,000
Accounts payable, accrued expenses and lease liabilities | (2,178,000) | (1,707,000)
Change in payable to licensor | 3,515,000 | (2,600,000)
Net cash used in operating activities | (35,019,000) | (62,820,000)
Cash flows from investing activities: |  |
Capital expenditures | (1,336,000) | (6,309,000)
Acquisition of licensed technology |  | (199,000)
Purchases of short-term investments | (170,472,000) |
Proceeds from maturities of short-term investments | 88,094,000 | 66,484,000
Net cash (used in)/provided by investing activities | (83,714,000) | 59,976,000
Cash flows from financing activities: |  |
Proceeds from loan payable | 1,758,000 |
Proceeds from issuance of common stock and pre-funded warrants in public offering, net of offering costs | 1,000 | 95,972,000
Proceeds from open market sales of common stock |  | 16,961,000
Proceeds from exercise of stock options | 177,000 | 969,000
Net cash provided by financing activities | 1,936,000 | 113,902,000
Net (decrease)/increase in cash, cash equivalents and restricted cash | (116,797,000) | 111,058,000
Cash, cash equivalents and restricted cash at beginning of year | 130,368,000 | 19,310,000
Cash, cash equivalents and restricted cash at end of year | 13,571,000 | 130,368,000
Supplemental cash flow information: |  |
Cash and cash equivalents | 12,596,000 | 129,258,000
Restricted cash | 975,000 | 1,110,000
Total cash, cash equivalents and restricted cash | 13,571,000 | 130,368,000
Shares returned in connection with arbitration ruling on licensing agreement |  | 1,472,000
Cash paid for interest |  |
Cash paid for taxes |  |

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