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v3.21.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 3 Months Ended
--- | ---
Mar. 31, 2021 | Mar. 31, 2020
Cash flows from operating activities: |  |
Net loss | $ (16,002,000) | $ (48,159,000)
Adjustments to reconcile net loss to cash used in operating activities: |  |
Non-cash licensed technology impairment charge |  | 32,916,000
Depreciation and amortization | 817,000 | 2,065,000
Stock option-based compensation expense | 1,083,000 | 1,256,000
Restricted stock-based compensation expense | 867,000 | 464,000
Non-cash interest expense |  | 600,000
Accretion and interest on short-term investments | 125,000 | (109,000)
Amortization of right-of-use lease assets | 268,000 | 245,000
Change in operating assets and liabilities: |  |
Prepaid expenses and other current assets | 882,000 | 416,000
Other assets | (20,000) |
Accounts payable, accrued expenses and lease liabilities | (3,024,000) | (2,926,000)
Change in payable to licensor | 1,419,000 |
Net cash used in operating activities | (13,585,000) | (13,232,000)
Cash flows from investing activities: |  |
Capital expenditures | (444,000) | (479,000)
Purchases of short-term investments | (15,164,000) | (75,392,000)
Proceeds from maturities of short-term investments | 24,984,000 |
Net cash provided by (used in) investing activities | 9,376,000 | (75,871,000)
Cash flows from financing activities: |  |
Proceeds from open market sales of common stock | 5,211,000 |
Proceeds from exercise of stock options | 667,000 |
Net cash provided by financing activities | 5,878,000 |
Net increase (decrease) in cash, cash equivalents and restricted cash | 1,669,000 | (89,103,000)
Cash, cash equivalents and restricted cash at beginning of period | 13,571,000 | 130,368,000
Cash, cash equivalents and restricted cash at end of period | 15,240,000 | 41,265,000
Supplemental cash flow information: |  |
Cash and cash equivalents | 14,265,000 | 40,155,000
Restricted cash | 975,000 | 1,110,000
Total cash, cash equivalents and restricted cash | 15,240,000 | 41,265,000
Cash paid for interest |  |
Cash paid for taxes |  |

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