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v3.22.1

Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |
Net loss | $ (84,936,000) | $ (84,234,000)
Adjustments to reconcile net loss to cash used in operating activities: |  |
Non-cash goodwill impairment charge | 32,466,000 |
Non-cash licensed technology impairment charge |  | 32,916,000
Non-cash gain on settlement with licensor | (6,743,000) |
Depreciation and amortization | 3,250,000 | 4,586,000
Stock option-based compensation expense | 5,250,000 | 5,853,000
Restricted stock-based compensation expense | 3,666,000 | 2,334,000
Non-cash PPP loan payable forgiveness income | (1,758,000) |
Non-cash interest expense | 67,000 | 600,000
Accretion and interest on short-term investments | 122,000 | (70,000)
Amortization of right-of-use lease assets | 1,214,000 | 1,015,000
Other |  | 347,000
Change in operating assets and liabilities: |  |
Accounts receivable | (3,000,000) |
Prepaid expenses, other current assets and restricted cash | 331,000 | 424,000
Other assets and restricted cash | (7,000) | (127,000)
Accounts payable, accrued expenses, lease liabilities and other liabilities | 825,000 | (2,178,000)
Payable to licensor | (16,412,000) | 3,515,000
Net cash used in operating activities | (65,665,000) | (35,019,000)
Cash flows from investing activities: |  |
Capital expenditures | (4,151,000) | (1,336,000)
Purchases of short-term investments | (20,163,000) | (170,472,000)
Proceeds from maturities of short-term investments | 90,376,000 | 88,094,000
Net cash provided by/(used in) investing activities | 66,062,000 | (83,714,000)
Cash flows from financing activities: |  |
Proceeds from loan payable |  | 1,758,000
Proceeds from issuance of common stock and warrants in public offering | 17,433,000 | 1,000
Payment of offering costs in public offering | (1,454,000) |
Proceeds from open market sales of common stock | 8,051,000 |
Proceeds from exercise of stock options | 831,000 | 177,000
Net cash provided by financing activities | 24,861,000 | 1,936,000
Net increase/(decrease) in cash, cash equivalents and restricted cash | 25,258,000 | (116,797,000)
Cash, cash equivalents and restricted cash at beginning of year | 13,571,000 | 130,368,000
Cash, cash equivalents and restricted cash at end of year | 38,829,000 | 13,571,000
Supplemental cash flow information: |  |
Cash and cash equivalents | 32,938,000 | 12,596,000
Restricted cash | 5,891,000 | 975,000
Total cash, cash equivalents and restricted cash | 38,829,000 | 13,571,000
Cash paid for interest |  |
Cash paid for taxes |  |
Additions to right-of-use lease assets obtained from new operating lease liabilities resulting from modification of original lease arrangement | $ 3,585,000 |

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