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STOCK-BASED COMPENSATION (Tables) | 6 Months Ended
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Jun. 30, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
SCHEDULE OF STOCK BASED COMPENSATION | The following table summarizes stock-based compensation expense for the three and six months ended June 30, 2022 and 2021 (in thousands): SCHEDULE OF STOCK BASED COMPENSATION
|  | For the three months ended June 30, |  |  | For the six months ended June 30 |
|  | 2022 |  |  | 2021 |  |  | 2022 |  |  | 2021 |
Research and development |  | $ | 540 |  |  | $ | 1,092 |  |  | $ | 556 |  |  | $ | 2,247 |
General and administrative |  |  | 184 |  |  |  | 1,336 |  |  |  | 1,030 |  |  |  | 2,131 |
Total stock-based compensation expense |  | $ | 724 |  |  | $ | 2,428 |  |  | $ | 1,586 |  |  | $ | 4,378 |
SCHEDULE OF WEIGHTED-AVERAGE ASSUMPTIONS TO ESTIMATE THE FAIR VALUE OF THE OPTIONS GRANTED | The Company estimated the fair value of stock options granted in the periods presented utilizing a Black-Scholes option-valuation model utilizing the following assumptions: SCHEDULE OF WEIGHTED-AVERAGE ASSUMPTIONS TO ESTIMATE THE FAIR VALUE OF THE OPTIONS GRANTED
|  |  | For the six months ended June 30, |
|  |  | 2022 |  |  |  | 2021 |
Expected volatility |  |  | 95.1% - 96.0% |  |  |  | 98.9% - 99.8% |
Expected term |  |  | 6.07 - 6.08 years |  |  |  | 5.25 - 6.08 years |
Risk-free interest rate |  |  | 1.7% - 3.3% |  |  |  | 0.9% - 1.2% |
Expected dividend yield |  |  | — |  |  |  | — |
SCHEDULE OF RESTRICTED STOCK AWARD ACTIVITY | The following table summarizes restricted stock award activity during the six months ended June 30, 2022: SCHEDULE OF RESTRICTED STOCK AWARD ACTIVITY
|  | Number of Awards |  |  | Weighted Average Grant Date Fair Value |
Outstanding at December 31, 2021 |  |  | 97,260 |  |  | $ | 46.59 |
Granted |  |  | 12,680 |  |  | $ | 6.29 |
Cancelled/forfeited |  |  | (27,161 | ) |  | $ | 39.38 |
Vested |  |  | (21,671 | ) |  | $ | 53.07 |
Outstanding at June 30, 2022 |  |  | 61,108 |  |  | $ | 39.14 |
2015 Equity Incentive Plan [Member] |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
SCHEDULE OF STOCK OPTIONS ACTIVITY | The following table summarizes stock option activity for the 2015 Incentive Plan during the six months ended June 30, 2022: SCHEDULE OF STOCK OPTIONS ACTIVITY
|  | Number of Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term (years) |  |  | Aggregate Intrinsic Value (in thousands) |
Outstanding at December 31, 2021 |  |  | 314,194 |  |  | $ | 38.48 |  |  |  | 7.63 |  |  | $ | — |
Granted |  |  | 7,760 |  |  | $ | 5.30 |  |  |  | — |  |  | $ | — |
Cancelled/forfeited |  |  | (56,556 | ) |  | $ | 35.31 |  |  |  | — |  |  | $ | — |
Exercised |  |  | — |  |  | $ | — |  |  |  | — |  |  | $ | — |
Outstanding at June 30, 2022 |  |  | 265,398 |  |  | $ | 38.18 |  |  |  | 6.69 |  |  | $ | 5 |
Exercisable |  |  | 148,066 |  |  | $ | 38.28 |  |  |  | 5.02 |  |  | $ | — |
Unvested |  |  | 117,332 |  |  | $ | 38.05 |  |  |  | 8.81 |  |  | $ | 5 |
2005 Equity Incentive Plan [Member] |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
SCHEDULE OF STOCK OPTIONS ACTIVITY | The following table summarizes stock option activity for the 2005 Incentive Plan during the six months ended June 30, 2022: SCHEDULE OF STOCK OPTIONS ACTIVITY
|  | Number of Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term (years) |  |  | Aggregate Intrinsic Value (in thousands) |
Outstanding at December 31, 2021 |  |  | 3,200 |  |  | $ | 32.00 |  |  |  | 1.80 |  |  | $ | — |
Cancelled/forfeited |  |  | — |  |  | $ | — |  |  |  | — |  |  | $ | — |
Exercised |  |  | — |  |  | $ | — |  |  |  | — |  |  | $ | — |
Outstanding at June 30, 2022 |  |  | 3,200 |  |  | $ | 32.00 |  |  |  | 1.29 |  |  | $ | — |
Exercisable |  |  | 3,200 |  |  | $ | 32.00 |  |  |  | 1.29 |  |  | $ | — |
Unvested |  |  | — |  |  | $ | — |  |  |  | — |  |  | $ | — |

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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year. + References No definition available. + Details
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