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STOCK-BASED COMPENSATION (Tables)

9 Months Ended

Sep. 30, 2022

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

SCHEDULE OF STOCK BASED COMPENSATION

The following table summarizes stock-based compensation expense for the three and nine months ended September 30, 2022 and 2021 (in thousands):

 SCHEDULE OF STOCK BASED COMPENSATION

		For the three months ended September 30,								For the nine months ended September 30
		2022				2021				2022				2021
Research and development		$	173			$	688			$	729			$	2,935
General and administrative			459				1,849				1,489				3,980
Total stock-based compensation expense		$	632			$	2,537			$	2,218			$	6,915

SCHEDULE OF WEIGHTED-AVERAGE ASSUMPTIONS TO ESTIMATE THE FAIR VALUE OF THE OPTIONS GRANTED

The Company estimated the fair value of stock options granted in the periods presented utilizing a Black-Scholes option-valuation model utilizing the following assumptions:

 SCHEDULE OF WEIGHTED-AVERAGE ASSUMPTIONS TO ESTIMATE THE FAIR VALUE OF THE OPTIONS GRANTED

			For the nine months ended September 30,
			2022				2021
Expected volatility			95.1% - 96.0%				91.8% - 99.8%
Expected term			6.07 - 6.08 years				5.25 - 6.08 years
Risk-free interest rate			1.7% - 3.3%				0.8% - 1.2%
Expected dividend yield			—				—

SCHEDULE OF RESTRICTED STOCK AWARD ACTIVITY

The following table summarizes restricted stock award activity during the nine months ended September 30, 2022:

 SCHEDULE OF RESTRICTED STOCK AWARD ACTIVITY

		Number of Awards				Weighted Average Grant Date Fair Value
Outstanding at December 31, 2021			97,260			$	46.59
Granted			779,722			$	3.12
Cancelled/forfeited			(30,742	)		$	40.65
Vested			(24,971	)		$	50.66
Outstanding at September 30, 2022			821,269			$	5.42

2015 Equity Incentive Plan [Member]

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

SCHEDULE OF STOCK OPTIONS ACTIVITY

The following table summarizes stock option activity for the 2015 Incentive Plan during the nine months ended September 30, 2022: 

SCHEDULE OF STOCK OPTIONS ACTIVITY

		Number of Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (years)				Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2021			314,194			$	38.48				7.63			$	—
Granted			7,760			$	5.30				—			$	—
Cancelled/forfeited			(82,510	)		$	39.31				—			$	—
Exercised			—			$	—				—			$	—
Outstanding at September 30, 2022			239,444			$	37.10				6.71			$	—
Exercisable			140,414			$	36.67				5.39			$	—
Unvested			99,030			$	37.72				8.58			$	—

2005 Equity Incentive Plan [Member]

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

SCHEDULE OF STOCK OPTIONS ACTIVITY

The following table summarizes stock option activity for the 2005 Incentive Plan during the nine months ended September 30, 2022:

 SCHEDULE OF STOCK OPTIONS ACTIVITY

		Number of Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (years)				Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2021			3,200			$	32.00				1.80			$	—
Cancelled/forfeited			—			$	—				—			$	—
Exercised			—			$	—				—			$	—
Outstanding at September 30, 2022			3,200			$	32.00				1.04			$	—
Exercisable			3,200			$	32.00				1.04			$	—
Unvested			—			$	—				—			$	—

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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