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STOCK-BASED COMPENSATION (Tables)
12 Months Ended
Dec. 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]  
SCHEDULE OF STOCK BASED COMPENSATION

The following table summarizes stock-based compensation (in thousands):

 

   2022   2021 
   For the year ended December 31, 
   2022   2021 
         
Research and development  $925   $3,299 
General and administrative   2,126    5,617 
Total stock-based compensation expense  $3,051   $8,916 
SCHEDULE OF WEIGHTED-AVERAGE ASSUMPTIONS TO ESTIMATE THE FAIR VALUE OF THE OPTIONS GRANTED

The Company estimated the fair value of stock options granted in the periods presented utilizing a Black-Scholes option-valuation model utilizing the following assumptions:

 

   For the year ended December 31, 
   2022   2021 
         
Expected volatility   95.1% - 96.0%   91.6% - 99.8%
Expected term   6.07 - 6.08 years    5.25 - 6.08 years 
Risk-free interest rate   1.7% - 3.3%   0.8% - 1.4%
Expected dividend yield   0%   0%
SCHEDULE OF RESTRICTED STOCK AWARD ACTIVITY

The following table summarizes restricted stock award activity:

 

   Number of Awards   Weighted Average Grant Date Fair Value Per Unit 
         
Outstanding at December 31, 2020   118,100   $44.50 
Granted   115,627   $43.00 
Cancelled/forfeited   (32,776)  $50.50 
Vested   (103,691)  $38.75 
Outstanding at December 31, 2021   97,260   $46.50 
Granted   779,722   $3.12 
Cancelled/forfeited   (32,498)  $38.80 
Vested   (27,526)  $48.63 
Outstanding at December 31, 2022   816,958   $5.35 
2015 Equity Incentive Plan [Member]  
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]  
SCHEDULE OF STOCK OPTIONS ACTIVITY

The following table summarizes stock option information for the 2015 Equity Incentive Plan:

 

   Number of Options   Weighted Average Exercise Price   Weighted Average Remaining Contractual Term (years)  

Aggregate Intrinsic Value

(in thousands)

 
                 
Outstanding at December 31, 2020   222,430   $55.25    6.86   $ 
Granted   195,092   $43.75       $ 
Cancelled/forfeited   (78,101)  $101.75       $ 
Exercised   (25,227)  $33.00       $ 
Outstanding at December 31, 2021   314,194   $38.48    7.63   $ 
Granted   7,760   $5.30       $ 
Cancelled/forfeited   (84,384)  $39.25       $ 
Exercised      $       $ 
Outstanding at December 31, 2022   237,570   $37.11    6.50   $ 
Exercisable   153,695   $36.34    5.49   $ 
Unvested   83,875   $38.53    8.33   $ 
SCHEDULE OF OPTIONS OUTSTANDING AND EXERCISABLE

Further information regarding options outstanding under the 2015 Equity Incentive Plan as of December 31, 2022 is summarized below:

 

            Weighted-Average       Weighted-Average 
Range of Exercise Prices   Number of Options Outstanding   Remaining Life In Years   Exercise Price   Number of Options Exercisable   Remaining Life in Years   Exercise Price 
                              
$4.00   $22.75    25,040    8.9   $17.25    6,794    8.8   $21.25 
 25.50    47.00    157,535    5.6    33.17    122,143    4.8    32.80 
 54.50    58.50    54,795    8.0    57.04    24,558    7.8    57.07 
 164.75    183.50    200    6.1    164.75    200    6.1    164.75 
           237,570              153,695           
2005 Equity Incentive Plan [Member]  
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]  
SCHEDULE OF STOCK OPTIONS ACTIVITY

The following table summarizes stock option information for the 2005 Incentive Plan:

 

   Number of Options   Weighted Average Exercise Price   Weighted Average Remaining Contractual Term (years)  

Aggregate Intrinsic Value

(in thousands)

 
                 
Outstanding at December 31, 2020   4,992   $213.75    2.87   $ 
Cancelled/forfeited   (1,792)  $538.25       $ 
Exercised      $       $ 
Outstanding at December 31, 2021   3,200   $32.00    1.80   $ 
Cancelled/forfeited      $       $ 
Exercised      $       $ 
Outstanding at December 31, 2022   3,200   $32.00    0.79   $ 
Exercisable   3,200   $32.00    0.79   $ 
Unvested      $       $ 
SCHEDULE OF OPTIONS OUTSTANDING AND EXERCISABLE

Further information regarding options outstanding under the 2005 Equity Incentive Plan as of December 31, 2022 is summarized below:

 

            Weighted-Average       Weighted-Average 
Range of Exercise Prices   Number of Options Outstanding   Remaining Life In Years   Exercise Price   Number of Options Exercisable   Remaining Life in Years   Exercise Price 
                              
$32.00   $32.00    3,200    0.8   $32.00    3,200    0.8   $32.00 
           3,200              3,200