<SEC-DOCUMENT>0000899140-23-000398.txt : 20230214
<SEC-HEADER>0000899140-23-000398.hdr.sgml : 20230214
<ACCEPTANCE-DATETIME>20230214162031
ACCESSION NUMBER:		0000899140-23-000398
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20230214
DATE AS OF CHANGE:		20230214
GROUP MEMBERS:		POINT72 CAPITAL ADVISORS, INC.
GROUP MEMBERS:		STEVEN A. COHEN

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ABEONA THERAPEUTICS INC.
		CENTRAL INDEX KEY:			0000318306
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				830221517
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-33655
		FILM NUMBER:		23629757

	BUSINESS ADDRESS:	
		STREET 1:		1330 AVENUE OF THE AMERICAS, 33RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
		BUSINESS PHONE:		646-813-4701

	MAIL ADDRESS:	
		STREET 1:		1330 AVENUE OF THE AMERICAS, 33RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PLASMATECH BIOPHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20140922

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ACCESS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19960209

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHEMEX PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19920703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Point72 Asset Management, L.P.
		CENTRAL INDEX KEY:			0001603466
		IRS NUMBER:				465064661
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
		BUSINESS PHONE:		203-890-2000

	MAIL ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>pt7213ga.htm
<DESCRIPTION>SCHEDULE 13G/A, AMENDMENT #2
<TEXT>
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    <div style="font-size: 12pt; font-weight: bold;">240.13d-102 Schedule 13G - Information to be included in statements filed</div>
    <div style="font-size: 12pt; font-weight: bold;">pursuant to 240.13d-1(b), (c), and (d) and amendments thereto</div>
    <div style="font-size: 12pt; font-weight: bold;">filed pursuant to 240.13d-2.</div>
    <div><br>
    </div>
    <div>
      <div style="font-size: 12pt;">Securities and Exchange Commission, Washington, D.C. 20549</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Schedule 13G</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Under the Securities Exchange Act of 1934</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(Amendment No. 1)*</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(Name of Issuer)</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Abeona Therapeutics&#160;Inc.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(Title of Class of Securities)</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Common Stock, par value $0.01 per share</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(CUSIP Number)</div>
      <div><br>
      </div>
      <div><font style="font-size: 12pt;">00289Y206<br>
        </font><br>
      </div>
      <div style="font-size: 12pt;">(Date of Event Which Requires Filing of this Statement)</div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt;">December 31, 2022</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Check the appropriate box to designate the rule pursuant to which this</div>
    <div style="font-size: 12pt;">Schedule is filed:</div>
    <div><br>
    </div>
    <div>
      <div style="font-size: 12pt;">[&#160; ] Rule 13d-1(b)</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">[ x ] Rule 13d-1(c)</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">[&#160; ] Rule 13d-1(d)</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">*The remainder of this cover page shall be filled out for a reporting person's<br>
        initial filing on this form with respect to the subject class of securities, and<br>
        for any subsequent amendment containing information which would alter the<br>
        disclosures provided in a prior cover page.</div>
      <div><br>
      </div>
      <div><font style="font-size: 12pt;">The information required in the remainder of this cover page shall not be<br>
          deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange<br>
          Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the<br>
          Act but shall be subject to all other provisions of the Act (however, see<br>
          the Notes).<br>
        </font><br>
      </div>
    </div>
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          <td colspan="2" style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 00289Y206</div>
          </td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Asset Management, L.P.</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
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          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 1,150,648 shares of Common Stock</div>
            <div style="text-indent: 144pt; font-size: 12pt;">&#160;&#160;&#160;&#160;&#160;128,000 shares of Common Stock issuable upon exercise of Warrants</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 1,150,648 shares of Common Stock</div>
            <div style="text-indent: 144pt; font-size: 12pt;">&#160;&#160;&#160;&#160;&#160;128,000 shares of Common Stock issuable upon exercise of Warrants</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="font-size: 12pt;">1,150,648 shares of Common Stock</div>
            <div style="font-size: 12pt;">128,000 shares of Common Stock issuable upon exercise of Warrants</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 7.4% (see item 4)</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) PN</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
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          <td colspan="2" style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 00289Y206</div>
          </td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Capital Advisors, Inc.</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 1,150,648 shares of Common Stock</div>
            <div style="text-indent: 144pt; font-size: 12pt;">&#160;&#160;&#160;&#160;&#160;128,000 shares of Common Stock issuable upon exercise of Warrants</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 1,150,648 shares of Common Stock</div>
            <div style="text-indent: 144pt; font-size: 12pt;">&#160;&#160;&#160;&#160;&#160;128,000 shares of Common Stock issuable upon exercise of Warrants</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="font-size: 12pt;">1,150,648 shares of Common Stock</div>
            <div style="font-size: 12pt;">128,000 shares of Common Stock issuable upon exercise of Warrants</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 7.4% (see Item 4)</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 94.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) CO</div>
          </td>
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            <div style="text-align: center; font-size: 12pt;">CUSIP No. 00289Y206</div>
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            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Steven A. Cohen</div>
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            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
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            <div style="font-size: 12pt;">(a)</div>
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            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
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            <div style="font-size: 12pt;">(b)X</div>
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            <div style="font-size: 12pt;">(3) SEC use only</div>
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            <div style="font-size: 12pt;">(4) Citizenship or place of organization United States</div>
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            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
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            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
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            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 1,150,648 shares of Common Stock</div>
            <div style="text-indent: 144pt; font-size: 12pt;">&#160;&#160;&#160;&#160;&#160;128,000 shares of Common Stock issuable upon exercise of Warrants</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
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            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
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            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 1,150,648 shares of Common Stock</div>
            <div style="text-indent: 144pt; font-size: 12pt;">&#160;&#160;&#160;&#160;&#160;128,000 shares of Common Stock issuable upon exercise of Warrants</div>
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          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
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            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="font-size: 12pt;">1,150,648 shares of Common Stock</div>
            <div style="font-size: 12pt;">128,000 shares of Common Stock issuable upon exercise of Warrants</div>
          </td>
          <td style="width: 5.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
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            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
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            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 7.4% (see item 4)</div>
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            <div style="font-size: 12pt;">(12) Type of reporting person (see instruction) IN</div>
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      <div style="font-size: 12pt;">Item 1(a) Name of issuer:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Abeona Therapeutics Inc.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Item 1(b) Address of issuer's principal executive offices:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">1330 Avenue of the Americas,&#160;33rd&#160;Floor,&#160;New York,&#160;NY&#160;10019</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">2(a) Name of person filing:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">This statement is filed by: (i) Point72 Asset Management, L.P. (&#8220;Point72 Asset Management&#8221;)<br>
        with respect to shares of common stock, par value $0.01 per share (&#8220;Common Stock&#8221;), of the<br>
        Issuer held by ( and issuable upon exercise of warrants held by) Point72 Associates, LLC, an<br>
        investment fund it manages ("Point72 Associates"); (ii) Point72 Capital Advisors, Inc. (&#8220;Point72<br>
        Capital Advisors Inc.&#8221;) with respect to Common Stock held by (and issuable upon exercise of<br>
        warrants held by) Point72 Associates and; (iii) Steven A. Cohen (&#8220;Mr. Cohen&#8221;) with respect to<br>
        Common Stock beneficially owned by Point72 Asset Management and Point72 Capital Advisors<br>
        Inc.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">2(b) Address or principal business office or, if none, residence:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">The address of the principal business office of Point72 Asset Management, Point72 Capital<br>
        Advisors Inc., and Mr. Cohen is 72 Cummings Point Road, Stamford, CT 06902.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">2(c) Citizenship:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a<br>
        Delaware corporation. Mr. Cohen is a United States citizen.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">2(d) Title of class of securities:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Common Stock, par value $0.01 per share</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">2(e) CUSIP Number:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">00289Y206</div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt; font-style: italic;">Item 3.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
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    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 4. </font>Ownership</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">The information required by Items 4(a) &#8211; (c) is set forth in Rows (5) &#8211; (11) of the cover page for<br>
      each Reporting Person hereto and is incorporated herein by reference for each Reporting Person.<br>
      Such information is as of the close of business on December 31, 2022.</div>
    <div><br>
    </div>
    <div>
      <div style="margin-right: 45pt; font-size: 12pt;">Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen own directly<br>
        no Common Stock. Pursuant to an investment management agreement, Point72 Asset<br>
        Management maintains investment and voting power with respect to the securities held<br>
        by Point72 Associates. Point72 Capital Advisors Inc. is the general partner of Point72<br>
        Asset Management. Mr. Cohen controls each of Point72 Asset Management and<br>
        Point72 Capital Advisors Inc.&#160;&#160; The filing of this statement should not be construed as<br>
        an admission that any of the foregoing persons or any reporting person is, for the<br>
        purposes of Section 13 of the Act, the beneficial owner of the shares of Common Stock<br>
        reported herein.</div>
      <div><br>
      </div>
      <div style="margin-right: 45pt; font-size: 12pt;">The percentage set forth in Row 11 of the cover page for each reporting person is based<br>
        on 17,175,799 shares of Common Stock outstanding as of November 7, 2022, as<br>
        disclosed in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the U.S. Securities<br>
        Exchange Commission on November 14, 2022, plus 128,000 shares of Common Stock<br>
        issuable upon exercise of Warrants.</div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 5. </font>Ownership of 5 Percent or Less of a Class.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">If this statement is being filed to report the fact that as of the date hereof</div>
    <div style="font-size: 12pt;">the reporting person has ceased to be the beneficial owner of more than</div>
    <div style="font-size: 12pt;">5 percent of the class of securities, check the following [].</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 6.</font>&#160; Ownership of More than 5 Percent on Behalf of Another Person.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Point72 Associates has the right to receive or the power to direct the receipt of dividends from,<br>
      or the proceeds from the sale of, the Common Stock reported herein.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 7.</font>&#160; Identification and Classification of the Subsidiary Which Acquired</div>
    <div style="font-size: 12pt;">the Security Being Reporting on by the Parent Holding Company or Control</div>
    <div style="font-size: 12pt;">Person.</div>
    <div><br>
    </div>
    <div>
      <div style="font-size: 12pt;">Not applicable</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;"><font style="font-style: italic;">Item 8. </font>Identification and Classification of Members of the Group</div>
      <div style="font-size: 12pt;"> <br>
      </div>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 9.</font>&#160; Notice of Dissolution of Group.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 10. </font>Certifications</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By signing below I certify that, to the best of my knowledge and belief, the securities referred to </div>
    <div style="font-size: 12pt;">above were not acquired and are not held for the purpose of or with the effect of changing or </div>
    <div style="font-size: 12pt;">influencing the control of the issuer of the securities and were not acquired and are not held </div>
    <div style="font-size: 12pt;">in connection with or as a participant in any transaction having that purpose or effect.</div>
    <div><br>
    </div>
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    <div style="font-size: 12pt;"><font style="font-style: italic;">Signature.</font>&#160; After reasonable inquiry and to the best of my knowledge and belief,</div>
    <div style="font-size: 12pt;">I certify that the information set forth in this statement is true, complete</div>
    <div style="font-size: 12pt;">and correct.</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div>
      <div style="font-size: 12pt;">Dated: <u>February 14, 2023</u></div>
      <div><br>
      </div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt;">POINT72 ASSET MANAGEMENT, L.P.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
    <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
    <div style="font-size: 12pt;">Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">POINT72 CAPITAL ADVISORS, INC.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
    <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
    <div style="font-size: 12pt;">Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">STEVEN A. COHEN</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
    <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
    <div style="font-size: 12pt;">Title: Authorized Person</div>
    <div><br>
    </div>
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