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STOCK-BASED COMPENSATION (Tables)

12 Months Ended

Dec. 31, 2023

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

SCHEDULE OF STOCK BASED COMPENSATION

The following table summarizes stock-based compensation (in thousands):

  SCHEDULE OF STOCK BASED COMPENSATION

		2023				2022
		For the year ended December 31,
		2023				2022
Research and development		$	1,085			$	925
General and administrative			3,683				2,126
Total stock-based compensation expense		$	4,768			$	3,051

SCHEDULE OF WEIGHTED-AVERAGE ASSUMPTIONS TO ESTIMATE THE FAIR VALUE OF THE OPTIONS GRANTED

The Company estimated the fair value of stock options granted in the periods presented utilizing a Black-Scholes option-pricing model utilizing the following assumptions:

  SCHEDULE OF WEIGHTED-AVERAGE ASSUMPTIONS TO ESTIMATE THE FAIR VALUE OF THE OPTIONS GRANTED

		For the year ended December 31,
		2023*				2022
Expected volatility (%)			n/a				95.1% - 96.0%
Expected term (years)			n/a				6.07 - 6.08 years
Risk-free interest rate (%)			n/a				1.7% - 3.3%
Expected dividend yield (%)			n/a				0%

* the Company did not grant any stock options in the year ended December 31, 2023.

SCHEDULE OF STOCK OPTION ACTIVITY

The following table summarizes stock option activity for the 2015 Incentive Plan and the 2005 Incentive Plan during (there were no stock options granted under the 2023 Incentive Plan or the Inducement Plan during the year ended December 31, 2023):

SCHEDULE OF STOCK OPTION ACTIVITY

		Number of Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (years)				Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2021			317,394			$	38.40				7.57			$	—
Granted			7,760			$	5.30				—			$	—
Cancelled/forfeited			(84,384	)		$	39.25				—			$	—
Exercised			—			$	—				—			$	—
Outstanding at December 31, 2022			240,770			$	37.04				6.42			$	—
Granted			—			$	—				—			$	—
Cancelled/forfeited			(61,769	)		$	32.59				—			$	—
Exercised			—			$	—				—			$	—
Outstanding at December 31, 2023			179,001			$	38.58				6.83			$	3
Exercisable			135,271			$	38.49				6.64			$	1
Unvested			43,730			$	38.85				7.43			$	2

SCHEDULE OF RESTRICTED STOCK AWARD ACTIVITY

The following table summarizes restricted stock award activity:

 SCHEDULE OF RESTRICTED STOCK AWARD ACTIVITY

		Number of Awards				Weighted Average Grant Date Fair Value Per Unit
Outstanding at December 31, 2021			97,260			$	46.50
Granted			779,722			$	3.12
Cancelled/forfeited			(32,498	)		$	38.80
Vested			(27,526	)		$	48.63
Outstanding at December 31, 2022			816,958			$	5.35
Granted			1,958,159			$	3.99
Cancelled/forfeited			(56,398	)		$	4.32
Vested			(270,550	)		$	5.59
Outstanding at December 31, 2023			2,448,169			$	4.25

2015 Equity Incentive Plan [Member]

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

SCHEDULE OF OPTIONS OUTSTANDING AND EXERCISABLE

As of December 31, 2023, there are no options outstanding under the 2005 Incentive Plan. Further information regarding options outstanding under the 2015 Incentive Plan as of December 31, 2023 is summarized below:

 SCHEDULE OF OPTIONS OUTSTANDING AND EXERCISABLE

												Weighted-Average												Weighted-Average
Range of Exercise Prices								Number of Options Outstanding				Remaining Life in Years				Exercise Price				Number of Options Exercisable				Remaining Life in Years				Exercise Price
$	4.00			$	22.75				20,240				8.0			$	16.52				10,117				7.9			$	17.47
	25.50				47.00				106,081				6.5				33.45				88,874				6.3				33.09
	54.50				58.50				52,480				7.2				56.98				36,080				7.2				56.98
	164.75				183.50				200				5.1				164.75				200				5.1				164.75
									179,001												135,271

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