<SEC-DOCUMENT>0001972481-25-000216.txt : 20250922
<SEC-HEADER>0001972481-25-000216.hdr.sgml : 20250922
<ACCEPTANCE-DATETIME>20250922162354
ACCESSION NUMBER:		0001972481-25-000216
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250922
DATE AS OF CHANGE:		20250922

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ABEONA THERAPEUTICS INC.
		CENTRAL INDEX KEY:			0000318306
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				830221517
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-15771
		FILM NUMBER:		251330369

	BUSINESS ADDRESS:	
		STREET 1:		6555 CARNEGIE AVE, 4TH FLOOR
		CITY:			CLEVELAND
		STATE:			OH
		ZIP:			44103
		BUSINESS PHONE:		646-813-4701

	MAIL ADDRESS:	
		STREET 1:		6555 CARNEGIE AVE, 4TH FLOOR
		CITY:			CLEVELAND
		STATE:			OH
		ZIP:			44103

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PLASMATECH BIOPHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20140922

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ACCESS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19960209

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHEMEX PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			O'Malley Brendan M.
		CENTRAL INDEX KEY:			0001884342
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		1330 AVENUE OF THE AMERICAS
		STREET 2:		33RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001884342</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000318306</issuerCik>
      <issuerName>ABEONA THERAPEUTICS INC.</issuerName>
      <secFileNumber>001-15771</secFileNumber>
      <issuerAddress>
        <com:street1>6555 CARNEGIE AVE, 4TH FLOOR</com:street1>
        <com:city>CLEVELAND</com:city>
        <com:stateOrCountry>OH</com:stateOrCountry>
        <com:zipCode>44103</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>646-813-4701</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>O'Malley Brendan M.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Stifel Nicolaus &amp; Company Inc</name>
        <address>
          <com:street1>501 N Broadway</com:street1>
          <com:city>St. Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63102</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>17376</noOfUnitsSold>
      <aggregateMarketValue>101749.00</aggregateMarketValue>
      <noOfUnitsOutstanding>51156736</noOfUnitsOutstanding>
      <approxSaleDate>09/22/2025</approxSaleDate>
      <securitiesExchangeName> Nasdaq </securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>09/21/2025</acquiredDate>
      <natureOfAcquisitionTransaction> Restricted Stock Units </natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired> Issuer </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1360</amountOfSecuritiesAcquired>
      <paymentDate>09/22/2025</paymentDate>
      <natureOfPayment> Cash </natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Brendan O'Malley</name>
        <address>
          <com:street1> 6555 Carnegie Ave Fl 4 </com:street1>
          <com:city> Cleveland </com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>44103</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle> Common Stock </securitiesClassTitle>
      <saleDate>07/09/2025</saleDate>
      <amountOfSecuritiesSold>17428</amountOfSecuritiesSold>
      <grossProceeds>102053.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>09/22/2025</noticeDate>
      <signature>/s/ Luca Lotito, as a duly authorized representative of STIFEL, as attorney-in-fact for Brendan O'Malley</signature>
    </noticeSignature>
  </formData>
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</SEC-DOCUMENT>
