<SUBMISSION>
<ACCESSION-NUMBER>0001181431-09-042450
<TYPE>3/A
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20090824
<FILING-DATE>20090902
<DATE-OF-FILING-DATE-CHANGE>20090902
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Greenberg Arthur
<CIK>0001456615
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>3/A
<ACT>34
<FILE-NUMBER>001-31791
<FILM-NUMBER>091051817
</FILING-VALUES>
<MAIL-ADDRESS>
<STREET1>7 WELLS AVENUE
<CITY>NEWTON
<STATE>MA
<ZIP>02459
</MAIL-ADDRESS>
</REPORTING-OWNER>
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>PRO PHARMACEUTICALS INC
<CIK>0001133416
<ASSIGNED-SIC>2834
<IRS-NUMBER>043562325
<STATE-OF-INCORPORATION>NV
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>189 WELLS ST
<STREET2>STE 200
<CITY>NEWTON
<STATE>MA
<ZIP>02459
<PHONE>6175590033
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>189 WELLS ST
<STREET2>STE 200
<CITY>NEWTON
<STATE>MA
<ZIP>02459
</MAIL-ADDRESS>
</ISSUER>
<DOCUMENT>
<TYPE>3/A
<SEQUENCE>1
<FILENAME>rrd252239.xml
<DESCRIPTION>FORM 3/A
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3/A</documentType>

    <periodOfReport>2009-08-24</periodOfReport>

    <dateOfOriginalSubmission>2009-08-24</dateOfOriginalSubmission>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001133416</issuerCik>
        <issuerName>PRO PHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>PWRP.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001456615</rptOwnerCik>
            <rptOwnerName>Greenberg Arthur</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O PRO-PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>7 WELLS AVENUE, SUITE 34</rptOwnerStreet2>
            <rptOwnerCity>NEWTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02459</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>500000</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">These shares were omitted from the reporting person's original Form 3 and comprise a grant of restricted stock granted on 2/13/09 in connection with an appointment to serve on the issuer's Compensation Committee, (but not as a director of the issuer), which is subject to forfeiture if Mr. Greenberg no longer serves as a director of the issuer, as follows: (i) 100%, if he is no longer serving as a director before February 13, 2010; (ii) 50%, if he is serving as a director on or after February 13, 2010 but no longer serving before May 13, 2010; (iii) 37.5%, if he is serving as a director on or after May 13, 2010 but no longer serving before August 13, 2010; (iv) 25%, if he is serving as a director on or after August 13, 2010 but no longer serving before November 13, 2010; and (v) 12.5%, if he is serving as a director on or after November 13, 2010 but no longer serving before February 13, 2011.  On August 24, 2009, Mr. Greenberg was elected to serve on the issuer's Board of Directors.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Maureen Foley as Attorney-in-Fact for Arthur Greenberg</signatureName>
        <signatureDate>2009-09-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
