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Dynavax Purchase (Details) - Dynavax purchase agreement $ in Thousands | 1 Months Ended | 12 Months Ended
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Jun. 30, 2022 USD ($) | Sep. 30, 2021 USD ($) | Dec. 31, 2020 USD ($) | Jul. 31, 2020 USD ($) | Dec. 31, 2022 USD ($) item | Dec. 31, 2021 USD ($)
Dynavax purchase agreement |  |  |  |  |  |
Upfront payment amount |  |  |  | $ 9,000 |  |
Payment of upfront amount |  |  | $ 4,000 | $ 5,000 |  |
Minimum milestone payment amount |  |  |  |  | $ 1,000 |
Maximum milestone payment amount |  |  |  |  | 10,000 |
Maximum development milestone payments |  |  |  |  | $ 170,000 |
Milestone payments made | $ 1,000 | $ 1,000 |  |  |  |
Number of commercial milestone to be made | item |  |  |  |  | 4 |
Maximum commercial milestone payments |  |  |  |  | $ 80,000 |
First and second development milestone payments in R&D |  |  |  |  | 1,000 | $ 1,000
Upon first commercial sale of product |  |  |  |  |  |
Dynavax purchase agreement |  |  |  |  |  |
Commercial milestone payment amount |  |  |  |  | 10,000 |
Upon first occurrence of annual net sales of $250000 |  |  |  |  |  |
Dynavax purchase agreement |  |  |  |  |  |
Commercial milestone payment amount |  |  |  |  | 20,000 |
Annual net sales |  |  |  |  | 250,000 |
Upon first occurrence of annual net sales of $500000 |  |  |  |  |  |
Dynavax purchase agreement |  |  |  |  |  |
Commercial milestone payment amount |  |  |  |  | 20,000 |
Annual net sales |  |  |  |  | 500,000 |
Upon first occurrence of annual net sales of $1000000 |  |  |  |  |  |
Dynavax purchase agreement |  |  |  |  |  |
Commercial milestone payment amount |  |  |  |  | 30,000 |
Annual net sales |  |  |  |  | 1,000,000 |
Aggregate annual net sales less than or equal to $1,000,000 |  |  |  |  |  |
Dynavax purchase agreement |  |  |  |  |  |
Annual net sales |  |  |  |  | $ 1,000,000 |
Annual royalty rate |  |  |  |  | 10.00% |
Aggregate annual net sales greater than $1,000,000 |  |  |  |  |  |
Dynavax purchase agreement |  |  |  |  |  |
Annual royalty rate |  |  |  |  | 12.00% |

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