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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022
Cash flows from operating activities |  |
Net loss | $ (117,863) | $ (92,094)
Adjustments to reconcile net loss to net cash used in operations: |  |
Depreciation expense | 3,492 | 2,525
Non-cash lease expense | 4,727 | 3,578
Stock-based compensation | 13,362 | 10,695
Interest amortization on marketable securities | (4,660) | (12)
Changes in operating assets and liabilities: |  |
Operating lease liabilities, net | (3,583) | (10,454)
Prepaid expenses and other current assets | 3,270 | 225
Accounts payable and accrued liabilities | 2,850 | 1,114
Other assets | (1,887) | (721)
Net cash used in operating activities | (100,292) | (85,144)
Cash flow from investing activities |  |
Purchases of marketable securities | (74,923) | (123,189)
Proceeds from maturities of marketable securities | 147,000 | 37,560
Purchases of property and equipment | (1,069) | (8,462)
Net cash provided by (used in) investing activities | 71,008 | (94,091)
Cash flow from financing activities |  |
Proceeds from the issuance of common stock from public offering and concurrent private placement, net of underwriter fees and issuance costs |  | 111,524
Payment of issuance costs related to underwritten public offering and concurrent private placement | (717) |
Proceeds from the issuance of common stock from at-the-market sales agreements, net of issuance costs | 4,578 | 4,451
Shares repurchased for tax withholdings upon vesting of restricted stock unit awards | (1,187) |
Proceeds from stock option exercises and the issuance of shares under ESPP | 264 | 1,165
Net cash provided by financing activities | 2,938 | 117,140
Net decrease in cash, cash equivalents and restricted cash equivalents | (26,346) | (62,095)
Cash, cash equivalents and restricted cash equivalents, beginning of period | 60,119 | 122,214
Cash, cash equivalents and restricted cash equivalents, end of period | 33,773 | 60,119
Supplemental disclosure of non-cash activities |  |
Right-of-use assets obtained in exchange for lease obligations |  | 23,376
Purchases of property and equipment in accounts payable and accrued liabilities | 70 | 38
Financing costs associated with the sale of common stock included in accounts payable and accrued expenses | $ 27 | $ 812

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