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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Pay vs Performance Disclosure |  |  |
Pay vs Performance Disclosure, Table |
Year |  | Summary Compensation Table Total for PEO(1) |  | Compensation Actually Paid to PEO(2) |  | Average Summary Compensation Table Total for Non-PEO NEOs(1) |  | Average Compensation Actually Paid to Non-PEO NEOs(2) |  | Value of Initial Fixed $100 Investment Based on Total Shareholder Return(3) |  | Net Income (Loss)(4) ($ thousands)
(a) |  | (b) |  | (c) |  | (d) |  | (e) |  | (f) |  | (g)
2023 |  | $ | 6,111,883 |  |  | $ | 6,379,295 |  |  | $ | 1,819,522 |  |  | $ | 1,836,461 |  |  | $ | 26.25 |  |  | $ | (219,710) |
2022 |  | $ | 4,292,242 |  |  | $ | (588,622) |  |  | $ | 1,662,966 |  |  | $ | 164,883 |  |  | $ | 37.29 |  |  | $ | 35,379 |
2021 |  | $ | 3,671,395 |  |  | $ | 4,275,744 |  |  | $ | 1,340,562 |  |  | $ | 1,079,921 |  |  | $ | 107.59 |  |  | $ | (25,687) |
Named Executive Officers, Footnote | The dollar amounts reported in column (b) are the amounts of total compensation reported for Dr. Brunn for each corresponding year in the “Total” column of the Summary Compensation Table. The dollar amounts reported in column (d) represent the average of the amounts reported for our Company’s Non-PEO NEOs as a group in the “Total” column of the Summary Compensation Table in each applicable year. The names of the Non-PEO NEOs included for purposes of calculating the average amounts in each applicable year are as follows: for 2023, Blaine Davis, Peter G. Traber, M.D., Lloyd Johnston, Ph.D., Metin Kurtoglu, M.D., Ph.D., and Chris Jewell, Ph.D.; for 2022, Blaine Davis, Kevin Tan, Peter G. Traber, M.D., Takashi Kei Kishimoto, Ph.D. and Lloyd Johnston, Ph.D.; and for 2021, Kevin Tan, Ann K. Donohue, Bradford D. Dahms, Peter G. Traber, M.D., Takashi Kei Kishimoto, Ph.D. and Lloyd Johnston, Ph.D. |  |
PEO Total Compensation Amount | $ 6,111,883 | $ 4,292,242 | $ 3,671,395
PEO Actually Paid Compensation Amount | $ 6,379,295 | (588,622) | 4,275,744
Adjustment To PEO Compensation, Footnote | The table below describes the adjustments, each of which is required by SEC rules, to calculate Compensation Actually Paid amounts from the Summary Compensation Total:
| Year | Named Executive Officers | Summary Compensation Table Total | Deduct Reported Value of Equity Awards Granted in the Year | Add Year-End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year | Add Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year | Year over Year Change in Value of Unvested Prior Equity Awards | Year over Year Change in Value of Vested Prior Equity Awards | Deduct Value of Prior Equity Awards that Failed to Meet Vesting Conditions in the Year | Compensation Actually Paid
| 2023 | PEO | $ | 6,111,883 |  | $ | (1,443,222) |  | $ | — |  | $ | 1,768,318 |  | $ | — |  | $ | (57,684) |  | $ | — |  | $ | 6,379,295 |
| Non-PEO NEOs Average | $ | 1,819,522 |  | $ | (310,158) |  | $ | — |  | $ | 379,350 |  | $ | — |  | $ | (52,253) |  | $ | — |  | $ | 1,836,461 |
| 2022 | PEO | $ | 4,292,242 |  | $ | (3,377,578) |  | $ | 934,511 |  | $ | — |  | $ | (1,415,406) |  | $ | (1,022,391) |  | $ | — |  | $ | (588,622) |
| Non-PEO NEOs Average | $ | 1,662,966 |  | $ | (1,163,216) |  | $ | 414,344 |  | $ | — |  | $ | (322,827) |  | $ | (196,484) |  | $ | (229,900) |  | $ | 164,883 |
| 2021 | PEO | $ | 3,671,395 |  | $ | (2,788,311) |  | $ | 2,430,089 |  | $ | 276,000 |  | $ | 63,955 |  | $ | 622,616 |  | $ | — |  | $ | 4,275,744 |
| Non-PEO NEOs Average | $ | 1,340,562 |  | $ | (927,505) |  | $ | 664,534 |  | $ | 50,600 |  | $ | 13,935 |  | $ | 81,433 |  | $ | (143,638) |  | $ | 1,079,921 |
Non-PEO NEO Average Total Compensation Amount | $ 1,819,522 | 1,662,966 | 1,340,562
Non-PEO NEO Average Compensation Actually Paid Amount | $ 1,836,461 | 164,883 | 1,079,921
Adjustment to Non-PEO NEO Compensation Footnote | The table below describes the adjustments, each of which is required by SEC rules, to calculate Compensation Actually Paid amounts from the Summary Compensation Total:
| Year | Named Executive Officers | Summary Compensation Table Total | Deduct Reported Value of Equity Awards Granted in the Year | Add Year-End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year | Add Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year | Year over Year Change in Value of Unvested Prior Equity Awards | Year over Year Change in Value of Vested Prior Equity Awards | Deduct Value of Prior Equity Awards that Failed to Meet Vesting Conditions in the Year | Compensation Actually Paid
| 2023 | PEO | $ | 6,111,883 |  | $ | (1,443,222) |  | $ | — |  | $ | 1,768,318 |  | $ | — |  | $ | (57,684) |  | $ | — |  | $ | 6,379,295 |
| Non-PEO NEOs Average | $ | 1,819,522 |  | $ | (310,158) |  | $ | — |  | $ | 379,350 |  | $ | — |  | $ | (52,253) |  | $ | — |  | $ | 1,836,461 |
| 2022 | PEO | $ | 4,292,242 |  | $ | (3,377,578) |  | $ | 934,511 |  | $ | — |  | $ | (1,415,406) |  | $ | (1,022,391) |  | $ | — |  | $ | (588,622) |
| Non-PEO NEOs Average | $ | 1,662,966 |  | $ | (1,163,216) |  | $ | 414,344 |  | $ | — |  | $ | (322,827) |  | $ | (196,484) |  | $ | (229,900) |  | $ | 164,883 |
| 2021 | PEO | $ | 3,671,395 |  | $ | (2,788,311) |  | $ | 2,430,089 |  | $ | 276,000 |  | $ | 63,955 |  | $ | 622,616 |  | $ | — |  | $ | 4,275,744 |
| Non-PEO NEOs Average | $ | 1,340,562 |  | $ | (927,505) |  | $ | 664,534 |  | $ | 50,600 |  | $ | 13,935 |  | $ | 81,433 |  | $ | (143,638) |  | $ | 1,079,921 |
Compensation Actually Paid vs. Total Shareholder Return | The following chart sets forth the relationship between Compensation Actually Paid to Our PEO, the average of Compensation Actually Paid to Our Non-PEO NEOs and our total shareholder return over the period covering fiscal years 2021, 2022, and 2023. A large component of our executive compensation is equity-based to align compensation with performance, but also includes other appropriate incentives such as cash bonuses that are designed to incentivize our executives to achieve annual corporate goals. We believe the equity-based compensation strongly aligns our PEO and Non-PEO NEOs’ interests with those of our shareholders to maximize long-term value and encourage long-term employment. |  |
Total Shareholder Return Amount | $ 26.25 | 37.29 | 107.59
Net Income (Loss) | $ (219,710,000) | 35,379,000 | (25,687,000)
PEO Name | Dr. Brunn |  |
Additional 402(v) Disclosure | As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act, and Item 402(v) of Regulation S-K, we must annually disclose in our proxy statement the relationship between our performance and the “compensation actually paid” to our Principal Executive Officer (“PEO”) and our non-PEO Named Executive Officers (collectively, the “Non-PEO NEOs”). Total Shareholder Return for each year reflects what the cumulative value of $100 would be if such amount were invested into our Company for that applicable year on December 31, 2020.Net income or (loss) as reported in our consolidated statements of operations and comprehensive income (loss) in our Annual Report on Form 10-K for the applicable year. |  |
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | $ (1,443,222) | (3,377,578) | (2,788,311)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 | 934,511 | 2,430,089
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 | (1,415,406) | 63,955
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 1,768,318 | 0 | 276,000
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (57,684) | (1,022,391) | 622,616
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 | 0 | 0
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (310,158) | (1,163,216) | (927,505)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 | 414,344 | 664,534
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 | (322,827) | 13,935
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 379,350 | 0 | 50,600
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (52,253) | (196,484) | 81,433
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | $ 0 | $ (229,900) | $ (143,638)

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