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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Pay vs Performance Disclosure      
Pay vs Performance Disclosure, Table
Year
Summary Compensation Table Total for PEO(1)
Compensation Actually Paid to PEO(2)
Average Summary Compensation Table Total for Non-PEO NEOs(1)
Average Compensation Actually Paid to Non-PEO NEOs(2)
Value of Initial Fixed $100 Investment Based on Total Shareholder Return(3)
Net Income (Loss)(4) ($ thousands)
(a)(b)(c)(d)(e)(f)(g)
2023$6,111,883 $6,379,295 $1,819,522 $1,836,461 $26.25 $(219,710)
2022$4,292,242 $(588,622)$1,662,966 $164,883 $37.29 $35,379 
2021$3,671,395 $4,275,744 $1,340,562 $1,079,921 $107.59 $(25,687)
    
Named Executive Officers, Footnote The dollar amounts reported in column (b) are the amounts of total compensation reported for Dr. Brunn for each corresponding year in the “Total” column of the Summary Compensation Table. The dollar amounts reported in column (d) represent the average of the amounts reported for our Company’s Non-PEO NEOs as a group in the “Total” column of the Summary Compensation Table in each applicable year. The names of the Non-PEO NEOs included for purposes of calculating the average amounts in each applicable year are as follows: for 2023, Blaine Davis, Peter G. Traber, M.D., Lloyd Johnston, Ph.D., Metin Kurtoglu, M.D., Ph.D., and Chris Jewell, Ph.D.; for 2022, Blaine Davis, Kevin Tan, Peter G.
Traber, M.D., Takashi Kei Kishimoto, Ph.D. and Lloyd Johnston, Ph.D.; and for 2021, Kevin Tan, Ann K. Donohue, Bradford D. Dahms, Peter G. Traber, M.D., Takashi Kei Kishimoto, Ph.D. and Lloyd Johnston, Ph.D.
    
PEO Total Compensation Amount $ 6,111,883 $ 4,292,242 $ 3,671,395
PEO Actually Paid Compensation Amount $ 6,379,295 (588,622) 4,275,744
Adjustment To PEO Compensation, Footnote The table below describes the adjustments, each of which is required by SEC rules, to calculate Compensation Actually Paid amounts from the Summary Compensation Total:
YearNamed Executive OfficersSummary Compensation Table TotalDeduct Reported Value of Equity Awards Granted in the YearAdd Year-End Fair Value of Outstanding and Unvested Equity Awards Granted in the YearAdd Fair Value as of Vesting Date of Equity Awards Granted and Vested in the YearYear over Year Change in Value of Unvested Prior Equity AwardsYear over Year Change in Value of Vested Prior Equity AwardsDeduct Value of Prior Equity Awards that Failed to Meet Vesting Conditions in the YearCompensation Actually Paid
2023PEO$6,111,883 $(1,443,222)$— $1,768,318 $— $(57,684)$— $6,379,295 
Non-PEO NEOs Average$1,819,522 $(310,158)$— $379,350 $— $(52,253)$— $1,836,461 
2022PEO$4,292,242 $(3,377,578)$934,511 $— $(1,415,406)$(1,022,391)$— $(588,622)
Non-PEO NEOs Average$1,662,966 $(1,163,216)$414,344 $— $(322,827)$(196,484)$(229,900)$164,883 
2021PEO$3,671,395 $(2,788,311)$2,430,089 $276,000 $63,955 $622,616 $— $4,275,744 
Non-PEO NEOs Average$1,340,562 $(927,505)$664,534 $50,600 $13,935 $81,433 $(143,638)$1,079,921 
    
Non-PEO NEO Average Total Compensation Amount $ 1,819,522 1,662,966 1,340,562
Non-PEO NEO Average Compensation Actually Paid Amount $ 1,836,461 164,883 1,079,921
Adjustment to Non-PEO NEO Compensation Footnote The table below describes the adjustments, each of which is required by SEC rules, to calculate Compensation Actually Paid amounts from the Summary Compensation Total:
YearNamed Executive OfficersSummary Compensation Table TotalDeduct Reported Value of Equity Awards Granted in the YearAdd Year-End Fair Value of Outstanding and Unvested Equity Awards Granted in the YearAdd Fair Value as of Vesting Date of Equity Awards Granted and Vested in the YearYear over Year Change in Value of Unvested Prior Equity AwardsYear over Year Change in Value of Vested Prior Equity AwardsDeduct Value of Prior Equity Awards that Failed to Meet Vesting Conditions in the YearCompensation Actually Paid
2023PEO$6,111,883 $(1,443,222)$— $1,768,318 $— $(57,684)$— $6,379,295 
Non-PEO NEOs Average$1,819,522 $(310,158)$— $379,350 $— $(52,253)$— $1,836,461 
2022PEO$4,292,242 $(3,377,578)$934,511 $— $(1,415,406)$(1,022,391)$— $(588,622)
Non-PEO NEOs Average$1,662,966 $(1,163,216)$414,344 $— $(322,827)$(196,484)$(229,900)$164,883 
2021PEO$3,671,395 $(2,788,311)$2,430,089 $276,000 $63,955 $622,616 $— $4,275,744 
Non-PEO NEOs Average$1,340,562 $(927,505)$664,534 $50,600 $13,935 $81,433 $(143,638)$1,079,921 
    
Compensation Actually Paid vs. Total Shareholder Return
The following chart sets forth the relationship between Compensation Actually Paid to Our PEO, the average of Compensation Actually Paid to Our Non-PEO NEOs and our total shareholder return over the period covering fiscal years 2021, 2022, and 2023. A large component of our executive compensation is equity-based to align compensation with performance, but also includes other appropriate incentives such as cash bonuses that are designed to incentivize our executives to achieve annual corporate goals. We believe the equity-based compensation strongly aligns our PEO and Non-PEO NEOs’ interests with those of our shareholders to maximize long-term value and encourage long-term employment.
TSR chart.jpg
    
Total Shareholder Return Amount $ 26.25 37.29 107.59
Net Income (Loss) $ (219,710,000) 35,379,000 (25,687,000)
PEO Name Dr. Brunn    
Additional 402(v) Disclosure
As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act, and Item 402(v) of Regulation S-K, we must annually disclose in our proxy statement the relationship between our performance and the “compensation actually paid” to our Principal Executive Officer (“PEO”) and our non-PEO Named Executive Officers (collectively, the “Non-PEO NEOs”).
Total Shareholder Return for each year reflects what the cumulative value of $100 would be if such amount were invested into our Company for that applicable year on December 31, 2020.Net income or (loss) as reported in our consolidated statements of operations and comprehensive income (loss) in our Annual Report on Form 10-K for the applicable year. 		   
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (1,443,222) (3,377,578) (2,788,311)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 934,511 2,430,089
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 (1,415,406) 63,955
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 1,768,318 0 276,000
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (57,684) (1,022,391) 622,616
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 0 0
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (310,158) (1,163,216) (927,505)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 414,344 664,534
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 (322,827) 13,935
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 379,350 0 50,600
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (52,253) (196,484) 81,433
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ 0 $ (229,900) $ (143,638)