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Segment Reporting (Details)
$ in Thousands
 3 Months Ended
Mar. 31, 2025
USD ($)
segment
Mar. 31, 2024
USD ($)
Segment Reporting Information [Line Items]    
Number of operating segments | segment 1  
Revenue:    
Collaboration and license revenue $ 400 $ 5,840
Grant revenue 700 0
Total revenue 1,100 5,840
Operating expenses:    
Research and development 14,674 9,738
General and administrative 8,315 9,450
Net loss (17,710) (56,824)
Operating Segment    
Revenue:    
Collaboration and license revenue 400 5,840
Grant revenue 700 0
Total revenue 1,100 5,840
Operating expenses:    
General and administrative 8,315 9,450
Other (income) expense, net (4,179) 43,476
Net loss (17,710) (56,824)
Operating Segment | Legacy Selecta programs    
Operating expenses:    
Research and development 0 2,777
Operating Segment | Descartes-08 for MG    
Operating expenses:    
Research and development 7,036 1,266
Operating Segment | Early stage programs    
Operating expenses:    
Research and development 990 127
Operating Segment | Research and development employee expenses    
Operating expenses:    
Research and development 3,702 3,241
Operating Segment | Research and development stock-based compensation expense    
Operating expenses:    
Research and development 1,275 712
Operating Segment | Research and development facilities and other expenses    
Operating expenses:    
Research and development $ 1,671 $ 1,615