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Revenue Arrangements (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Jun. 30, 2025 | Jun. 30, 2024 | Jun. 30, 2025 | Jun. 30, 2024 | Dec. 31, 2024 | Jun. 28, 2024 | Jan. 31, 2023 | Jun. 30, 2020
Disaggregation of Revenue [Line Items] |  |  |  |  |  |  |  |
Unsatisfied performance obligation | $ 0 |  | $ 0 |  | $ 0 |  |  |
Accounts receivable | 354 |  | 354 |  | 872 |  |  |
Collaboration and license revenue | 0 | $ 33,271 | 400 | $ 39,111 |  |  |  |
Grant revenue | 298 | 174 | 998 | 174 |  |  |  |
National Institute of Neurological Disorders and Stroke of the National Institutes of Health Funding |  |  |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |  |  |
Government assistance, award amount |  | 1,500 |  | 1,500 |  |  |  |
Government assistance, potential additional award amount | 1,500 |  | 1,500 |  |  |  |  |
Government assistance, asset, current | 100 |  | 100 |  | 600 |  |  |
Grant revenue | 200 | 200 | 900 | 200 |  |  |  |
Astellas | License |  |  |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |  |  |
Contract liability |  |  |  |  |  |  | $ 10,000 |
Future contingent additional payments |  |  |  |  |  |  | $ 340,000 |
Unsatisfied performance obligation | 0 |  | 0 |  |  |  |  |
Accounts receivable | 0 |  | 0 |  | 100 |  |  |
Revenue recognized | 0 | 500 | 0 | 6,300 |  |  |  |
Revenue recognized from performance obligations related to prior periods as a result of change in transaction price |  |  |  | 3,200 |  |  |  |
SOBI |  |  |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |  |  |
Revenue recognized |  | 30,000 |  | 30,000 |  |  |  |
Collaboration and license revenue |  | $ 32,800 |  | $ 32,800 |  |  |  |
SOBI | License |  |  |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |  |  |
Contract liability |  |  |  |  |  | $ 30,000 |  | $ 75,000
Future contingent additional payments |  |  |  |  |  |  |  | $ 630,000
Accounts receivable | 100 |  | 100 |  | 100 |  |  |
Revenue recognized | $ 0 |  | $ 0 |  | $ 30,000 |  |  |

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