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Segment Reporting (Details)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2025
USD ($)
Mar. 31, 2025
USD ($)
Jun. 30, 2024
USD ($)
Mar. 31, 2024
USD ($)
Jun. 30, 2025
USD ($)
segment
Jun. 30, 2024
USD ($)
Segment Reporting Information [Line Items]            
Number of operating segments | segment         1  
Revenue:            
Collaboration and license revenue $ 0   $ 33,271   $ 400 $ 39,111
Grant revenue 298   174   998 174
Total revenue 298   33,445   1,398 39,285
Operating expenses:            
Research and development 14,869   12,661   29,543 22,399
General and administrative 7,240   7,027   15,555 16,477
Net income (loss) 15,886 $ (17,710) 13,836 $ (56,824) (1,824) (42,988)
Operating Segment            
Revenue:            
Collaboration and license revenue 0   33,271   400 39,111
Grant revenue 298   174   998 174
Total revenue 298   33,445   1,398 39,285
Operating expenses:            
General and administrative 7,240   7,027   15,555 16,477
Other (income) expense, net (37,697)   (79)   45,098 43,397
Net income (loss) 15,886   13,836   (1,824) (42,988)
Operating Segment | Legacy Selecta programs            
Operating expenses:            
Research and development 0   3,570   0 6,347
Operating Segment | Descartes-08 for MG            
Operating expenses:            
Research and development 5,035   2,945   12,071 4,211
Operating Segment | Early stage programs            
Operating expenses:            
Research and development 1,715   528   2,705 655
Operating Segment | Research and development employee expenses            
Operating expenses:            
Research and development 4,254   2,184   7,956 5,425
Operating Segment | Research and development stock-based compensation expense            
Operating expenses:            
Research and development 1,810   776   3,085 1,488
Operating Segment | Research and development facilities and other expenses            
Operating expenses:            
Research and development $ 2,055   $ 2,658   $ 3,726 $ 4,273