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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Pay vs Performance Disclosure      
Pay vs Performance Disclosure, Table
Year
Summary Compensation Table Total for PEO(1)
Compensation Actually Paid to PEO(2)
Average Summary Compensation Table Total for Non-PEO NEOs(1)
Average Compensation Actually Paid to Non-PEO NEOs(2)
Value of Initial Fixed $100 Investment Based on Total Shareholder Return(3)
Net (Loss) Income (4) ($ thousands)
(a)(b)(c)(d)(e)(f)(g)
2024$7,314,211 $6,543,925 $2,790,743 $2,529,608 $21.13 $(77,424)
2023$6,111,883 $6,379,295 $1,819,522 $1,836,461 $24.40 $(219,710)
2022$4,292,242 $(588,622)$1,662,966 $164,883 $34.66 $35,379 
    
Named Executive Officers, Footnote The dollar amounts reported in column (b) are the amounts of total compensation reported for Dr. Brunn for each corresponding year in the “Total” column of the Summary Compensation Table. The dollar amounts reported in column (d) represent the average of the amounts reported for our Company’s Non-PEO NEOs as a group in the “Total” column of the Summary Compensation Table in each applicable year. The names of the Non-PEO NEOs included for purposes of calculating the average amounts in each applicable year are as follows: for 2024, Blaine Davis, Metin Kurtoglu, M.D., Ph.D., and Christopher Jewell, Ph.D.; for 2023, Blaine Davis, Peter G. Traber, M.D., Lloyd Johnston, Ph.D., Metin Kurtoglu, M.D., Ph.D., and Christopher Jewell, Ph.D.; and for 2022, Blaine Davis, Kevin Tan, Peter G. Traber, M.D., Takashi Kei Kishimoto, Ph.D. and Lloyd Johnston, Ph.D.    
PEO Total Compensation Amount $ 7,314,211 $ 6,111,883 $ 4,292,242
PEO Actually Paid Compensation Amount $ 6,543,925 6,379,295 (588,622)
Adjustment To PEO Compensation, Footnote The table below describes the adjustments, each of which is required by SEC rules, to calculate Compensation Actually Paid amounts from the Summary Compensation Total:
YearNamed Executive OfficersSummary Compensation Table TotalDeduct Reported Value of Equity Awards Granted in the YearAdd Year-End Fair Value of Outstanding and Unvested Equity Awards Granted in the YearAdd Fair Value as of Vesting Date of Equity Awards Granted and Vested in the YearYear over Year Change in Value of Unvested Prior Equity AwardsYear over Year Change in Value of Vested Prior Equity AwardsDeduct Value of Prior Equity Awards that Failed to Meet Vesting Conditions in the YearCompensation Actually Paid
2024PEO$7,314,211 $(6,209,780)$5,439,494 $— $— $— $— $6,543,925 
Non-PEO NEOs Average$2,790,743 $(2,105,182)$1,844,047 $— $— $— $— $2,529,608 
2023PEO$6,111,883 $(1,443,222)$— $1,768,318 $— $(57,684)$— $6,379,295 
Non-PEO NEOs Average$1,819,522 $(310,158)$— $379,350 $— $(52,253)$— $1,836,461 
2022PEO$4,292,242 $(3,377,578)$934,511 $— $(1,415,406)$(1,022,391)$— $(588,622)
Non-PEO NEOs Average$1,662,966 $(1,163,216)$414,344 $— $(322,827)$(196,484)$(229,900)$164,883 
    
Non-PEO NEO Average Total Compensation Amount $ 2,790,743 1,819,522 1,662,966
Non-PEO NEO Average Compensation Actually Paid Amount $ 2,529,608 1,836,461 164,883
Adjustment to Non-PEO NEO Compensation Footnote The table below describes the adjustments, each of which is required by SEC rules, to calculate Compensation Actually Paid amounts from the Summary Compensation Total:
YearNamed Executive OfficersSummary Compensation Table TotalDeduct Reported Value of Equity Awards Granted in the YearAdd Year-End Fair Value of Outstanding and Unvested Equity Awards Granted in the YearAdd Fair Value as of Vesting Date of Equity Awards Granted and Vested in the YearYear over Year Change in Value of Unvested Prior Equity AwardsYear over Year Change in Value of Vested Prior Equity AwardsDeduct Value of Prior Equity Awards that Failed to Meet Vesting Conditions in the YearCompensation Actually Paid
2024PEO$7,314,211 $(6,209,780)$5,439,494 $— $— $— $— $6,543,925 
Non-PEO NEOs Average$2,790,743 $(2,105,182)$1,844,047 $— $— $— $— $2,529,608 
2023PEO$6,111,883 $(1,443,222)$— $1,768,318 $— $(57,684)$— $6,379,295 
Non-PEO NEOs Average$1,819,522 $(310,158)$— $379,350 $— $(52,253)$— $1,836,461 
2022PEO$4,292,242 $(3,377,578)$934,511 $— $(1,415,406)$(1,022,391)$— $(588,622)
Non-PEO NEOs Average$1,662,966 $(1,163,216)$414,344 $— $(322,827)$(196,484)$(229,900)$164,883 
    
Compensation Actually Paid vs. Total Shareholder Return
CAPvsTSR.jpg
    
Total Shareholder Return Amount $ 21.13 24.40 34.66
Net Income (Loss) $ (77,424,000) $ (219,710,000) $ 35,379,000
PEO Name Dr. Brunn Dr. Brunn Dr. Brunn
Additional 402(v) Disclosure
As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act, and Item 402(v) of Regulation S-K, we must annually disclose in our proxy statement the relationship between our performance and the “compensation actually paid” to our Principal Executive Officer (“PEO”) and our non-PEO Named Executive Officers (collectively, the “Non-PEO NEOs”).
Total Shareholder Return for each year reflects what the cumulative value of $100 would be if such amount were invested into our Company for that applicable year on December 31, 2021.Net (loss) or income as reported in our consolidated statements of operations and comprehensive (loss) income in our Annual Report on Form 10-K for the applicable year. 		   
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (6,209,780) $ (1,443,222) $ (3,377,578)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 5,439,494 0 934,511
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 0 (1,415,406)
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 1,768,318 0
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 (57,684) (1,022,391)
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 0 0
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (2,105,182) (310,158) (1,163,216)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 1,844,047 0 414,344
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 0 (322,827)
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 379,350 0
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 (52,253) (196,484)
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ 0 $ 0 $ (229,900)