<SEC-DOCUMENT>0001140361-25-000685.txt : 20250110
<SEC-HEADER>0001140361-25-000685.hdr.sgml : 20250110
<ACCEPTANCE-DATETIME>20250110060156
ACCESSION NUMBER:		0001140361-25-000685
CONFORMED SUBMISSION TYPE:	POS AM
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250110
DATE AS OF CHANGE:		20250110

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cartesian Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001453687
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		POS AM
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-281204
		FILM NUMBER:		25520050

	BUSINESS ADDRESS:	
		STREET 1:		7495 NEW HORIZON WAY
		CITY:			FREDERICK
		STATE:			MD
		ZIP:			21703
		BUSINESS PHONE:		301-348-8698

	MAIL ADDRESS:	
		STREET 1:		7495 NEW HORIZON WAY
		CITY:			FREDERICK
		STATE:			MD
		ZIP:			21703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SELECTA BIOSCIENCES INC
		DATE OF NAME CHANGE:	20090109
</SEC-HEADER>
<DOCUMENT>
<TYPE>POS AM
<SEQUENCE>1
<FILENAME>ny20041059x8_posam.htm
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<TEXT>
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      <hr style="height: 4px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">As filed with the Securities and Exchange Commission on January 10, 2025</div>
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    <div style="text-align: right; color: #000000; font-weight: bold;">Registration No. 333-281204&#8195;&#8195;</div>
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    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">WASHINGTON, D.C. 20549</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">Post-Effective</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">Amendment No. 1</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">to</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">FORM S-1</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 24pt; font-weight: bold;">Cartesian Therapeutics, Inc.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
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            <div style="text-align: center; color: #000000; font-weight: bold;">2834</div>
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            <div style="text-align: center; color: #000000; font-weight: bold;">26-1622110</div>
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            <div style="text-align: center; color: #000000; font-weight: bold;">(State or other jurisdiction of</div>
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            <div style="text-align: center; color: #000000; font-weight: bold;">(Primary Standard Industrial</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Classification Code Number)</div>
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            <div style="text-align: center; color: #000000; font-weight: bold;">(I.R.S. Employer</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Identification No.)</div>
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    <div style="text-align: center; color: #000000; font-weight: bold;">7495 New Horizon Way</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Frederick, MD 21703</div>
    <div style="text-align: center; font-weight: bold;">(301) 348-8698</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(Address, including zip code, and telephone number, including area code, of registrant&#8217;s principal executive offices)</div>
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    <div style="text-align: center; color: #000000; font-weight: bold;">Carsten Brunn, Ph.D.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">President and Chief Executive Officer</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Cartesian Therapeutics, Inc.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">7495 New Horizon Way</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Frederick, MD 21703</div>
    <div style="text-align: center; font-weight: bold;">(301) 348-8698</div>
    <div style="text-align: center; font-weight: bold;">(301) 348-8698</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
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    <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">Copies to:</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Brian K. Rosenzweig</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Sarah C. Griffiths</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Covington &amp; Burling LLP</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">One International Place, Suite 1020</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Boston, Massachusetts 02110</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(617) 603-8805</div>
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    <div style="color: #000000;"><font style="font-weight: bold;">Approximate date of commencement of proposed sale to the public</font>: From time to time after the effective date of this Registration Statement.</div>
    <div><br>
    </div>
    <div style="color: #000000;">If any of the securities being registered on this form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</font></div>
    <div><br>
    </div>
    <div style="color: #000000;">If this form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier
      effective registration statement for the same offering. &#8201;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
    <div><br>
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    <div style="color: #000000;">If this form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration
      statement for the same offering. &#8201;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
    <div><br>
    </div>
    <div style="color: #000000;">If this form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration
      statement for the same offering. &#8201;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
    <div><br>
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    <div style="color: #000000;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated
      filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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            <div style="color: #000000;">Non-accelerated filer</div>
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            <div style="color: #000000;">Smaller reporting company</div>
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            <div>&#8203;</div>
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            <div style="color: #000000;">Emerging growth company</div>
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          <td style="width: 1.49%; vertical-align: middle;">&#160;</td>
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            <div style="color: #000000;"><font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
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    <div style="color: #000000;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section
      7(a)(2)(B) of the Securities Act. &#8201;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
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    <div style="color: #000000; font-weight: bold;">The Registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states
      that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until the registration statement shall become effective on such date as the Commission, acting pursuant
      to said Section 8(a), may determine.</div>
    <div style="text-align: right; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-weight: bold;"> <br>
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      <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
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    <div style="text-align: center; text-indent: 18pt; color: #000000; font-weight: bold;">EXPLANATORY NOTE</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">TERMINATION OF REGISTRATION STATEMENT</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; color: #000000;">Cartesian Therapeutics, Inc. (the &#8220;Company&#8221;) filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) a Registration Statement on Form S-1 (File No. 333-281204) on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1453687/000114036124035433/ny20033174x1_s1.htm">August 2, 2024</a>, as amended by (i) Pre-Effective Amendment No. 1 to the Registration Statement on Form S-1, filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1453687/000114036124040584/ny20033174x2_s1a.htm">September 9, 2024</a>, and (ii) Pre-Effective Amendment No. 2 to the Registration Statement on Form S-1, filed with the SEC on <a href="https://www.sec.gov/Archives/edgar/data/1453687/000114036124041567/ny20033174x4_s1a.htm">September 20, 2024</a>, which was declared effective by the SEC on <a href="https://www.sec.gov/Archives/edgar/data/1453687/999999999524003053/xslEFFECTX01/primary_doc.xml">October 1, 2024</a> (as amended, the &#8220;Original Registration Statement&#8221;).</div>
    <div><br>
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    <div style="text-align: justify; text-indent: 36pt;"><font style="color: #000000;">The Original Registration Statement was filed to register an aggregate of up to 6,501,150 shares of the Company&#8217;s common stock, $0.0001 par value per share (&#8220;common
        stock&#8221;), which consisted of (i) up to 3,563,247 shares of common stock originally issued in a private placement to certain institutional and accredited investors and (ii) up to 2,937,903 shares of common stock issuable upon the conversion of
        2,937,903 shares of Series B Non-Voting Convertible Preferred Stock, par value $0.0001, issued in such private placement (the 6,501,150 shares of common stock, the &#8220;Registered Shares&#8221;). The Original Registration Statement was filed while the
        Company was ineligible to use Form S-3. As of the date hereof, the Company meets the eligibility requirements of Form S-3 and therefore may use its Registration Statement on Form S-3 (File No. 333-</font>&#160;<font style="color: #000000;">283806),
        which was filed with the SEC on <a href="https://www.sec.gov/Archives/edgar/data/1453687/000114036124049432/ny20039376x3_s3.htm">December 13, 2024</a> and declared effective by the SEC on January 8, 2025 (the &#8220;New Registration Statement&#8221;).</font></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; color: #000000;">Pursuant to the Company&#8217;s undertaking as required by Item 512(a)(3) of Regulation S-K, this Post-Effective Amendment No. 1 is being filed to terminate the effectiveness of the
      Original Registration Statement and to deregister, as of the effective date of this Post-Effective Amendment No. 1, all the Registered Shares that remain unsold under the Original Registration Statement as of the date thereof. The Registered Shares
      that remain unsold as of the date of the New Registration Statement are registered under the New Registration Statement.</div>
    <div><br>
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    <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURES</div>
    <div><br>
    </div>
    <div style="color: #000000;">Pursuant to the requirements of the Securities Act, the Registrant has duly caused this Post-Effective Amendment No. 1 to the Original Registration Statement to be signed on its behalf by the undersigned, thereunto duly
      authorized, in the City of Frederick, State of Maryland, on January 10, 2025.</div>
    <div><br>
    </div>
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          <td colspan="2" style="vertical-align: top;">
            <div style="color: #000000; font-weight: bold;">CARTESIAN THERAPEUTICS, INC.</div>
          </td>
        </tr>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">&#160;</td>
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          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 4%; vertical-align: top; padding-bottom: 2px;">
            <div style="color: #000000;">By:</div>
          </td>
          <td style="width: 46%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: #000000;">/s/ Carsten Brunn, Ph.D.</div>
          </td>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">&#160;</td>
          <td style="width: 46%; vertical-align: top;">
            <div style="color: #000000;">Name: Carsten Brunn, Ph.D.</div>
          </td>
        </tr>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">&#160;</td>
          <td style="width: 46%; vertical-align: top;">
            <div style="color: #000000;">President and Chief Executive Officer</div>
          </td>
        </tr>

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    <div><br>
    </div>
    <div style="color: #000000;">Note: No other person is required to sign this Post-Effective Amendment No. 1 to the Original Registration Statement in reliance upon Rule 478 under the Securities Act of 1933, as amended.</div>
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</SEC-DOCUMENT>
