<SEC-DOCUMENT>0001140361-25-000680.txt : 20250110
<SEC-HEADER>0001140361-25-000680.hdr.sgml : 20250110
<ACCEPTANCE-DATETIME>20250110060045
ACCESSION NUMBER:		0001140361-25-000680
CONFORMED SUBMISSION TYPE:	POS AM
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250110
DATE AS OF CHANGE:		20250110

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cartesian Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001453687
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		POS AM
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-275171
		FILM NUMBER:		25520003

	BUSINESS ADDRESS:	
		STREET 1:		7495 NEW HORIZON WAY
		CITY:			FREDERICK
		STATE:			MD
		ZIP:			21703
		BUSINESS PHONE:		301-348-8698

	MAIL ADDRESS:	
		STREET 1:		7495 NEW HORIZON WAY
		CITY:			FREDERICK
		STATE:			MD
		ZIP:			21703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SELECTA BIOSCIENCES INC
		DATE OF NAME CHANGE:	20090109
</SEC-HEADER>
<DOCUMENT>
<TYPE>POS AM
<SEQUENCE>1
<FILENAME>ny20041059x7_posam.htm
<DESCRIPTION>POS AM
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    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">As filed with the Securities and Exchange Commission on January 10, 2025</div>
    <div style="text-align: right; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Registration No. 333-275171</div>
    <div>
      <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Post-Effective</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Amendment No. 1</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">to</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">FORM S-3</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 24pt; font-weight: bold;">CARTESIAN THERAPEUTICS, INC.</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z35de7da2d8734c038b5baeebd2c07ac4" cellpadding="0" cellspacing="0">

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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Delaware</div>
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          <td style="width: 33.34%; vertical-align: bottom;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">2834</div>
          </td>
          <td style="width: 33.32%; vertical-align: bottom;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">26-1622110</div>
          </td>
        </tr>
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          <td style="width: 33.33%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(State or other jurisdiction of</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">incorporation or organization)</div>
          </td>
          <td style="width: 33.34%; vertical-align: bottom;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(Primary Standard Industrial</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Classification Code Number)</div>
          </td>
          <td style="width: 33.32%; vertical-align: bottom;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(I.R.S. Employer</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Identification Number)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">7495 New Horizon Way</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Frederick, Maryland 21703</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(301) 348-8698</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(Address, including zip code, and telephone number, including area code, of registrant&#8217;s principal executive offices)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Carsten Brunn, Ph.D.</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">President and Chief Executive Officer</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Cartesian Therapeutics, Inc.</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">7495 New Horizon Way</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Frederick, Maryland 21703</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(301) 348-8698</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-style: italic; font-weight: bold;">With copies to:</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Brian K. Rosenzweig</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Sarah C. Griffiths</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Covington &amp; Burling LLP</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">One International Place, Suite 1020</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Boston, Massachusetts 02110</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(617) 603-8805</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;"><font style="font-weight: bold;">Approximate date of commencement of proposed sale to the public</font>: From time to time after this registration statement becomes effective.</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: &#8194;&#9744;</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered
      only in connection with dividend or interest reinvestment plans, check the following box. <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</font></div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration
      statement number of the earlier effective registration statement for the same offering. &#8201;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the
      earlier effective registration statement for the same offering. &#8201;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule
      462(e) under the Securities Act, check the following box.&#8194;&#9744;</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities
      pursuant to Rule 413(b) under the Securities Act, check the following box.&#8194;&#9744;</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the
      definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div style="font-family: 'Times New Roman', Times, serif;"> <br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z959d67da9bf84948b499c5b8e730e599" cellpadding="0" cellspacing="0">

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          <td style="width: 41.51%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;">Large accelerated filer</div>
          </td>
          <td style="width: 7.3%; vertical-align: bottom;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
          </td>
          <td style="width: 43.9%; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman', Times, serif;">Accelerated filer</div>
          </td>
          <td style="width: 7.3%; vertical-align: bottom;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</div>
          </td>
        </tr>
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          <td style="width: 41.51%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;">Non-accelerated filer</div>
          </td>
          <td style="width: 7.3%; vertical-align: bottom;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
          </td>
          <td style="width: 43.9%; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman', Times, serif;">Smaller reporting company</div>
          </td>
          <td style="width: 7.3%; vertical-align: bottom;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 41.51%; vertical-align: top;">&#160;</td>
          <td style="width: 7.3%; vertical-align: bottom;">&#160;</td>
          <td style="width: 43.9%; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman', Times, serif;">Emerging growth company</div>
          </td>
          <td style="width: 7.3%; vertical-align: bottom;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
          </td>
        </tr>

    </table>
    <div style="font-family: 'Times New Roman', Times, serif;"> <br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
      standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#8201;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">The Registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further
      amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until the registration statement shall become effective on such date
      as the Commission, acting pursuant to said Section 8(a), may determine.</div>
    <div>
      <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
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    <div style="text-align: center; text-indent: 18pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">EXPLANATORY NOTE</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">TERMINATION OF REGISTRATION STATEMENT</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">Cartesian Therapeutics, Inc. (the &#8220;Company&#8221;) filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) a Registration Statement on Form S-3 (File No.
      333-275171) on <a href="https://www.sec.gov/Archives/edgar/data/1453687/000119312523263204/d541568ds3.htm">October 25, 2023</a>, as amended by Pre-Effective Amendment No. 1 to the Registration Statement on Form S-3, filed with the SEC on <a href="https://www.sec.gov/Archives/edgar/data/1453687/000119312523286814/d605498ds3a.htm">December 1, 2023</a>, which was declared effective by the SEC on <a href="https://www.sec.gov/Archives/edgar/data/1453687/999999999523003516/xslEFFECTX01/primary_doc.xml">December 1, 2023</a> (as amended, the &#8220;Original Registration Statement&#8221;).</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">The Original Registration Statement was filed to register an aggregate of up to $200,000,000 of shares of the Company&#8217;s common stock, preferred stock,
      debt securities, warrants, and/or units, and securities as may be issuable upon conversion, redemption, repurchase, exchange or exercise of any of the foregoing (collectively, the &#8220;Registered Securities&#8221;). No Registered Securities were issued and
      sold pursuant to the Original Registration Statement. As of the date hereof, the Company meets the eligibility requirements of Form S-3 and therefore intends to file a new Registration Statement on Form S-3 (the &#8220;New Registration Statement&#8221;). The New
      Registration Statement is being filed to replace the Original Registration Statement.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">Pursuant to the Company&#8217;s undertaking as required by Item 512(a)(3) of Regulation S-K, this Post-Effective Amendment No. 1 is being filed to terminate
      the effectiveness of the Original Registration Statement and to deregister, as of the effective date of this Post-Effective Amendment No. 1, all the Registered Securities that remain unsold under the Original Registration Statement as of the date
      thereof.</div>
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    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">SIGNATURES</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">Pursuant to the requirements of the Securities Act, the Registrant has duly caused this Post-Effective Amendment No. 1 to the Original Registration Statement to be signed on its behalf by the
      undersigned, thereunto duly authorized, in the City of Frederick, State of Maryland, on January 10, 2025.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z61d32aad6be744d399bc7dbb794c828d" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom;">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">CARTESIAN THERAPEUTICS, INC.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman', Times, serif;">By:</div>
          </td>
          <td style="width: 44%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">/s/ Carsten Brunn, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 44%; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman', Times, serif;">Name: Carsten Brunn, Ph.D.</div>
            <div style="font-family: 'Times New Roman', Times, serif;">President and Chief Executive Officer</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">Note: No other person is required to sign this Post-Effective Amendment No. 1 to the Original Registration Statement in reliance upon Rule 478 under the Securities Act of 1933, as amended.</div>
    <div style="font-family: 'Times New Roman', Times, serif;">
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