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Note 11 - 401(k) Savings Plan (Details Textual) - USD ($) $ in Millions | 9 Months Ended
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Sep. 30, 2025 | Sep. 30, 2024
Defined Contribution Plan, Cost | $ 1.4 | $ 1.4
First 3% of Each Participant's Contributions [Member] |  |
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay | 100.00% |
Second Two Percent Of Each Participants Contributions [Member] |  |
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay | 50.00% |

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- Definition Amount of cost for defined contribution plan. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 715 -SubTopic 70 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480794/715-70-50-1 + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- Definition Percentage of employees' gross pay for which the employer contributes a matching contribution to a defined contribution plan. + References No definition available. + Details
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Namespace Prefix: | us-gaap_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | duration

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- Details
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Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | us-gaap_RetirementPlanTypeAxis=pbyi_SecondTwoPercentOfEachParticipantsContributionsMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |