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Note 12 - Commitments and Contingencies (Details Textual) - USD ($) | 1 Months Ended | 12 Months Ended | 27 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Sep. 30, 2021 | Jun. 30, 2020 | Dec. 31, 2022 | Dec. 31, 2023 | Mar. 31, 2023 | Oct. 31, 2022 | Jul. 18, 2014
Milestone Payments Maximum Amount |  |  |  |  |  | $ 287,300,000 | $ 187,500,000
Percentage of Unpaid Portion of Milestone Payments Interest Rate |  | 6.25% |  |  |  |  |
Milestone Payment | $ 1,800,000 |  |  |  |  |  |
Upfront License Fee |  |  |  |  |  | 7,000,000 |
AstraZeneca Litigation [Member] | Subsidiary of Common Parent [Member] |  |  |  |  |  |  |
Litigation Settlement, Amount Awarded from Other Party |  |  |  | $ 107,500,000 |  |  |
Pfizer License Agreement [Member] |  |  |  |  |  |  |
Revenue from Contract with Customer, Including Assessed Tax |  |  | $ 250,000,000 |  |  |  |
Potential Milestone Payments |  |  |  |  | $ 12,500,000 |  |
Takeda [Member] |  |  |  |  |  |  |
Milestone Payments Maximum Amount |  |  |  |  |  | 287,300,000 |
Upfront License Fee |  |  |  |  |  | $ 7,000,000 |

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